Akr1b10 Gene Summary [Mouse]

Predicted to enable geranylgeranyl reductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and retinal dehydrogenase activity. Located in mitochondrion. Is expressed in adrenal gland. Orthologous to several human genes including AKR1B10 (aldo-keto reductase family 1 member B10). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Akr1b10
Official Name
aldo-keto reductase family 1, member B10 (aldose reductase) [Source:MGI Symbol;Acc:MGI:1915111]
Ensembl ID
ENSMUSG00000061758
Bio databases IDs NCBI: 67861 Ensembl: ENSMUSG00000061758
Aliases aldo-keto reductase family 1, member B10 (aldose reductase)
Synonyms 2310005E10Rik, Akr1b16, aldo-keto reductase family 1 member B10, aldo-keto reductase family 1, member B10, LOC100910708
Species
Mouse, Mus musculus
OrthologiesRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akr1b10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • NADP-retinol dehydrogenase
  • estradiol 17beta-dehydrogenase
  • Aldo-keto reductase (AKR) superfamily
  • retinal dehydrogenase
  • enzyme
  • alcohol dehydrogenase (NADP)
  • NADPH binding
  • binding protein
  • indanol dehydrogenase
  • NADP binding
  • CH-OH group:NAD or NADP oxidoreductase
  • Aldo/keto reductase family
  • retinal binding
  • geranylgeranyl reductase
  • aldehyde reductase

Pathways

Biological processes and signaling networks where the Akr1b10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
regulated by
  • aflatoxin B1
  • NKX2-2-AS1
  • cinnamaldehyde
regulates
  • polyols
  • retinol

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Extracellular Space
  • lysosome
  • Mitochondria
  • cytosol

Gene-Specific Assays for Results You Can Trust

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