Adamtsl3 Gene Summary [Rat]
Predicted to be involved in extracellular matrix organization. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular matrix. Orthologous to human ADAMTSL3 (ADAMTS like 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adamtsl3 |
| Official Name | ADAMTS-like 3 [Source:RGD Symbol;Acc:1305155] |
| Ensembl ID | ENSRNOG00000010840 |
| Bio databases IDs | |
| Aliases | ADAMTS-like 3 |
| Synonyms | 9230119C12RIK, ADAMTS-like 3, C130057K09, KIAA1233, mKIAA1233 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adamtsl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- immunoglobulin domain
- ADAMTS cysteine-rich domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- PLAC (protease and lacunin) domain
- protein binding
- Spondin-like TSP1 domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- asthma
- chronic obstructive pulmonary disease
- COVID-19
- schizophrenia
- peptic ulcer disease
- heart failure
- idiopathic scoliosis
- non-insulin-dependent diabetes mellitus
- uterine cancer
regulated by
- MKNK1
- 1810019D21Rik
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- intracellular membrane-bounded organelle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adamtsl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular matrix organization
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding