Prame

Predicted to enable nuclear retinoic acid receptor binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including negative regulation of retinoic acid receptor signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Predicted to be located in chromatin; nucleoplasm; and plasma membrane. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in myeloid leukemia. Orthologous to human PRAME (PRAME nuclear receptor transcriptional regulator). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prame often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.