Prame Gene Summary [Rat]
Predicted to enable nuclear retinoic acid receptor binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including negative regulation of retinoic acid receptor signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Predicted to be located in chromatin; nucleoplasm; and plasma membrane. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in myeloid leukemia. Orthologous to human PRAME (PRAME nuclear receptor transcriptional regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prame |
| Official Name | preferentially expressed antigen in melanoma [Source:RGD Symbol;Acc:1596887] |
| Ensembl ID | ENSRNOG00000011113 |
| Bio databases IDs | |
| Aliases | preferentially expressed antigen in melanoma |
| Synonyms | 4930534P07Rik, LOC100365087, Prame, PRAME like, X-linked 1, RGD1564204 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prame often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 regulatory subunit 42
- retinoic acid receptor binding
- protein binding activity, bridging
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
phenotypes
- B-Cell Chronic Lymphocytic Leukemia
- Hodgkin's lymphoma
- acute myeloid leukemia
- acute promyelocytic leukemia
- breast cancer
- chronic myeloid leukemia
- lung adenocarcinoma
- mantle cell lymphoma
- megakaryocytic leukemia
- melanoma
- Multiple Myeloma
- myelodysplastic syndrome
- myeloid leukemia
- neuroblastoma
- Osteosarcoma
- ovary adenocarcinoma
- precursor lymphoblastic lymphoma/leukemia
- Uveal Melanoma
- acute lymphoblastic leukemia
- acute megakaryocytic leukemia
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- nucleoplasm
- chromatin