Zfyve19 Gene Summary [Rat]
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in midbody abscission; mitotic cytokinesis checkpoint signaling; and negative regulation of cytokinesis. Predicted to be active in centrosome; cleavage furrow; and midbody. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human ZFYVE19 (zinc finger FYVE-type containing 19). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfyve19 |
| Official Name | zinc finger FYVE-type containing 19 [Source:RGD Symbol;Acc:1561576] |
| Ensembl ID | ENSRNOG00000012528 |
| Bio databases IDs | |
| Aliases | zinc finger FYVE-type containing 19 |
| Synonyms | 1500041L05RIK, ANCHR, MPFYVE, PFIC9, zinc finger, FYVE domain containing 19, zinc finger FYVE-type containing 19 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zfyve19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- FYVE zinc finger
- B-box-type zinc finger superfamily
- Protein present in Fab1, YOTB, Vac1, and EEA1
- PHD finger superfamily
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- midbody
- cleavage furrow
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zfyve19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- abscission
- negative regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- centrosome
- cleavage furrow
- cytoplasm
- midbody
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- phosphatidylinositol-3-phosphate binding