Pkd2l1 Gene Summary [Rat]
Predicted to enable several functions, including monoatomic ion channel activity; muscle alpha-actinin binding activity; and transmembrane transporter binding activity. Predicted to contribute to monoatomic cation channel activity and sour taste receptor activity. Predicted to be involved in several processes, including detection of chemical stimulus involved in sensory perception of sour taste; monoatomic cation transmembrane transport; and protein homotetramerization. Predicted to be located in several cellular components, including actin cytoskeleton; cell surface; and non-motile cilium. Predicted to be part of calcium channel complex and receptor complex. Predicted to be active in membrane. Orthologous to human PKD2L1 (polycystin 2 like 1, transient receptor potential cation channel). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pkd2l1 |
| Official Name | polycystin 2 like 1, transient receptor potential cation channel [Source:RGD Symbol;Acc:1306261] |
| Ensembl ID | ENSRNOG00000012591 |
| Bio databases IDs | |
| Aliases | polycystin 2 like 1, transient receptor potential cation channel |
| Synonyms | B830002B15, BC046386, PCL, PKD2L, PKDL, polycystic kidney disease 2-like 1, polycystin-2L, polycystin 2 like 1, transient receptor potential cation channel, TRPP3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pkd2l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ferredoxin I 4Fe-4S cluster domain
- identical protein binding
- ion channel
- taste receptor
- cytoskeletal protein binding
- cytoplasmic domain
- Polycystin domain
- ion channel binding
- extracellular loop
- loop domain
- Polycystin cation channel
- calcium activated cation channel
- osmosensor
- sodium channel
- Ion transport protein
- calcium channel
- channel/pore class transporter
- actinin binding
- EF-hand domain pair
- calcium-activated potassium channel
- calcium ion binding
- EFh
- inorganic uptake permease
- protein binding
- cation transporter
- ligand-gated ion channel
- cation channel
Pathways
Biological processes and signaling networks where the Pkd2l1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- lung squamous cell carcinoma
- squamous cell lung cancer
- biliary tract disease
- dermatological disorder
- kainic acid-induced epileptic seizure
- cardiovascular disorder
regulates
- Na+
- K+
- PKD1L3
- cation
- inorganic cation
role in cell
- expression in
- excitability
- length
- conductance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- non-motile cilium
- cell surface
- cellular membrane
- actin cytoskeleton
- Endoplasmic Reticulum
- cytosol
- primary cilia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pkd2l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transmembrane transport
- sensory perception of sour taste
- smoothened signaling pathway
- detection of chemical stimulus involved in sensory perception of sour taste
- response to water
- detection of mechanical stimulus
- cation transport
- protein homotetramerization
- calcium ion transmembrane transport
- cellular response to acidity
- sodium ion transmembrane transport
- detection of chemical stimulus involved in sensory perception of taste
Cellular Component
Where in the cell the gene product is active
- calcium channel complex
- intracellular membrane-bounded organelle
- membrane
- actin cytoskeleton
- cytosol
- cytoplasmic vesicle
- receptor complex
- cilium membrane
- endoplasmic reticulum
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- calcium-activated potassium channel activity
- sour taste receptor activity
- identical protein binding
- calcium channel activity
- sodium channel activity
- cation channel activity
- cation transmembrane transporter activity
- alpha-actinin binding
- muscle alpha-actinin binding
- ion channel binding
- calcium activated cation channel activity
- protein binding
- calcium ion binding
- cytoskeletal protein binding