Cldn19 Gene Summary [Rat]
Predicted to enable cell-cell adhesion mediator activity; identical protein binding activity; and paracellular tight junction channel activity. Predicted to be involved in several processes, including bicellular tight junction assembly; paracellular transport; and regulation of gene expression. Predicted to act upstream of or within apical junction assembly; neuronal action potential propagation; and tight junction organization. Predicted to be located in several cellular components, including Schmidt-Lanterman incisure; basolateral plasma membrane; and mesaxon. Predicted to be active in bicellular tight junction and plasma membrane. Human ortholog(s) of this gene implicated in renal hypomagnesemia 5 with ocular involvement. Orthologous to human CLDN19 (claudin 19). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cldn19 |
| Official Name | claudin 19 [Source:RGD Symbol;Acc:1305000] |
| Ensembl ID | ENSRNOG00000007922 |
| Bio databases IDs | |
| Aliases | claudin 19 |
| Synonyms | claudin-19, HOMG5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cldn19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cell adhesion molecule binding
- transmembrane domain
- PMP-22/EMP/MP20/Claudin family
- extracellular loop
- protein binding
- identical protein binding
- transporter
Pathways
Biological processes and signaling networks where the Cldn19 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal failure
- breast cancer
- colorectal cancer
- renal hypomagnesemia type 5 with ocular involvement
- germ cell neoplasia
- yolk sac neoplasm
- renal hypomagnesemia type 5 with or without ocular involvement
- gait disturbance
- hypomagnesemia
- ophthalmic disorder
role in cell
- proliferation
- migration
- formation
- assembly
- abnormal morphology
- organization
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- Cytoplasm
- cell surface
- apical compartment
- perinuclear region
- cellular membrane
- Nucleus
- intercellular junctions
- cell-cell contacts
- basolateral membrane
- paranodal junctions
- inner mesaxons
- mesaxons
- Schmidt-Lanterman incisures
- tight junctions
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cldn19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of wound healing
- calcium-independent cell-cell adhesion
- negative regulation of cell proliferation
- cell adhesion
- visual perception
- negative regulation of gene expression
- positive regulation of gene expression
- positive regulation of protein phosphorylation
- tight junction assembly
- neuronal action potential propagation
- actin cytoskeleton organization
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- tight junction
- perinuclear region of cytoplasm
- apical junction complex
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- structural molecule activity