Hmgb2 Gene Summary [Rat]
Enables lipid binding activity. Involved in animal organ regeneration; nervous system development; and positive regulation of nucleobase-containing compound metabolic process. Predicted to be located in several cellular components, including chromosome; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be part of protein-containing complex. Orthologous to human HMGB2 (high mobility group box 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmgb2 |
| Official Name | high mobility group box 2 [Source:RGD Symbol;Acc:69291] |
| Ensembl ID | ENSRNOG00000013167 |
| Bio databases IDs | |
| Aliases | high mobility group box 2 |
| Synonyms | high mobility group box 2-like 1, high mobility group box 2 like 2, HMG2, Hmgb2l1, Hmgb2l2, RGD1561694, RGD1564519 |
| Species | Rat, Rattus norvegicus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hmgb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA binding
- double-stranded DNA binding
- nucleic acid binding
- high mobility group (HMG)-box domain superfamily
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- DNA bending protein
- sequence-specific DNA binding
- DNA binding
Pathways
Biological processes and signaling networks where the Hmgb2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Extracellular Space
- perinuclear region
- chromosome
- chromatin