Defb4 Gene Summary [Rat]
Predicted to enable CCR6 chemokine receptor binding activity and chemoattractant activity. Predicted to be involved in cell chemotaxis; defense response to Gram-negative bacterium; and defense response to Gram-positive bacterium. Predicted to be active in extracellular space. Orthologous to several human genes including DEFB4B (defensin beta 4B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Defb4 |
| Official Name | defensin beta 4 [Source:RGD Symbol;Acc:619944] |
| Ensembl ID | ENSRNOG00000013939 |
| Bio databases IDs | |
| Aliases | defensin beta 4 |
| Synonyms | BD-5, Defb2, Defb3, Defb4, Defb5, defensin beta 4, defensin beta 5, defensin β 4, defensin β 5 |
| Species | Rat, Rattus norvegicus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Defb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- phosphatidylinositol-4,5-bisphosphate binding
- Beta defensin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
phenotypes
- Mandibular Neoplasms
- Mycobacterium Infections
- bacterial pneumonia
- Common Cold
- Cystic Fibrosis
- lung disease
- Pulmonary Alveolar Proteinosis
- Pulmonary Fibrosis
- pulmonary sarcoidosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space