Defb4 Gene Summary [Rat]
Predicted to enable CCR6 chemokine receptor binding activity and chemoattractant activity. Predicted to be involved in cell chemotaxis; defense response to Gram-negative bacterium; and defense response to Gram-positive bacterium. Predicted to be active in extracellular space. Orthologous to several human genes including DEFB4B (defensin beta 4B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Defb4 |
| Official Name | defensin beta 4 [Source:RGD Symbol;Acc:619944] |
| Ensembl ID | ENSRNOG00000013939 |
| Bio databases IDs | |
| Aliases | defensin beta 4 |
| Synonyms | BD-5, Defb2, Defb3, Defb4, Defb5, defensin beta 4, defensin beta 5, defensin β 4, defensin β 5 |
| Species | Rat, Rattus norvegicus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Defb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- phosphatidylinositol-4,5-bisphosphate binding
- Beta defensin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space