Aox1 Gene Summary [Rat]
Enables aldehyde oxidase activity. Predicted to be involved in xenobiotic metabolic process. Predicted to be located in several cellular components, including intercellular bridge; microtubule cytoskeleton; and nuclear body. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human AOX1 (aldehyde oxidase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aox1 |
| Official Name | aldehyde oxidase 1 [Source:RGD Symbol;Acc:620528] |
| Ensembl ID | ENSRNOG00000015354 |
| Bio databases IDs | |
| Aliases | aldehyde oxidase 1 |
| Synonyms | ALDEHYDE OXIDASE, aldehyde oxidase 1, AO, AOH1, Aox-2, Moro, Ro, XD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aox1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- flavin adenine dinucleotide binding
- L-amino acid ligase C-terminal domain 2
- xanthine dehydrogenase, molybdopterin binding subunit
- aldehyde oxidase
- iron ion binding
- enzyme
- xanthine dehydrogenase E subunit
- Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
- identical protein binding
- 4-hydroxybenzoyl-CoA reductase, gamma subunit
- FAD binding domain in molybdopterin dehydrogenase
- binding protein
- [2Fe-2S] binding domain
- protein homodimerization
- Molybdopterin cofactor-binding domain
- CO dehydrogenase flavoprotein C-terminal domain
- xanthine dehydrogenase, small subunit
Pathways
Biological processes and signaling networks where the Aox1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- late-onset Alzheimer disease
- androgenic alopecia
- epithelial cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- breast carcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
- liver cancer
regulates
- benzaldehyde
- retinaldehyde
- xenobiotic
- butyraldehyde
- 2-hydroxypyrimidine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cytoplasmic bridges
- cytosol
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aox1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- xenobiotic metabolic process
- lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- FAD binding
- identical protein binding
- protein homodimerization activity
- iron ion binding
- NAD binding
- flavin adenine dinucleotide binding
- aldehyde oxidase activity
- 2 iron, 2 sulfur cluster binding
- molybdopterin cofactor binding