Tm4sf20 Gene Summary [Rat]
Predicted to be involved in negative regulation of proteolysis. Predicted to be located in endoplasmic reticulum membrane; focal adhesion; and plasma membrane. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in specific language impairment. Orthologous to human TM4SF20 (transmembrane 4 L six family member 20). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tm4sf20 |
| Official Name | transmembrane 4 L six family member 20 [Source:RGD Symbol;Acc:1588633] |
| Ensembl ID | ENSRNOG00000015460 |
| Bio databases IDs | |
| Aliases | transmembrane 4 L six family member 20 |
| Synonyms | 1810018L02Rik, Betagenin, LOC108348188, LOC682510, PRO994, SLI5, TCCE518, transmembrane 4 L six family member 20 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tm4sf20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- L6 membrane protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- specific language impairment type 5
- streptozotocin-induced diabetes
regulates
- ERK1/2
- D-glucose
- INS
- Hb A
- proinsulin
role in cell
- growth
- proliferation
- phosphorylation in
- apoptosis
- mass
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal adhesions
- Plasma Membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tm4sf20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of proteolysis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- focal adhesion
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding