Prl2a1 Gene Summary [Rat]
Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in carotid artery disease and impulse control disorder. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prl2a1 |
| Official Name | Prolactin family 2, subfamily a, member 1 [Source:RGD Symbol;Acc:620121] |
| Ensembl ID | ENSRNOG00000016463 |
| Bio databases IDs | |
| Aliases | Prolactin family 2, subfamily a, member 1 |
| Synonyms | Ghd21, Ghd5, PLP-M, Prlpm, prolactin family 2, subfamily A, member 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prl2a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Somatotropin/prolactin hormone family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- SMTNL1
- Influenza A virus (A/WSN/1933(H1N1))
- SH-SY5Y cells
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space