Cir1 Gene Summary [Rat]
Predicted to enable histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within in utero embryonic development and negative regulation of transcription by RNA polymerase II. Predicted to be located in centrosome and nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Orthologous to human CIR1 (corepressor interacting with RBPJ, CIR1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cir1 |
| Official Name | corepressor interacting with RBPJ, 1 [Source:RGD Symbol;Acc:1309199] |
| Ensembl ID | ENSRNOG00000018719 |
| Bio databases IDs | |
| Aliases | corepressor interacting with RBPJ, 1 |
| Synonyms | 1700023B02Rik, 2810021A19Rik, Cicr, CIR, corepressor interacting with RBPJ, 1, corepressor interacting with RBPJ, CIR1, LOC675589, RGD1309199, THE1B/CIR1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cir1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-terminal domain of CBF1 interacting co-repressor CIR
- transcription regulator
- binding protein
- protein kinase binding
- transcription co-repressor
- histone deacetylase binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cir1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- RNA splicing
- negative regulation of transcription, DNA-dependent
- in utero embryonic development
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- nuclear speck
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- histone deacetylase binding
- transcription corepressor activity