CIR1 Gene Summary [Human]
Enables histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nuclear speck. Part of protein-containing complex. Colocalizes with centrosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CIR1 |
| Official Name | corepressor interacting with RBPJ, CIR1 [Source:HGNC Symbol;Acc:HGNC:24217] |
| Ensembl ID | ENSG00000138433 |
| Bio databases IDs | |
| Aliases | corepressor interacting with RBPJ, CIR1, recepin, CBF1 interacting corepressor |
| Synonyms | 1700023B02Rik, 2810021A19Rik, Cicr, CIR, corepressor interacting with RBPJ, 1, corepressor interacting with RBPJ, CIR1, LOC675589, RGD1309199, THE1B/CIR1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CIR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-terminal domain of CBF1 interacting co-repressor CIR
- transcription regulator
- binding protein
- protein kinase binding
- transcription co-repressor
- histone deacetylase binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CIR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- RNA splicing
- negative regulation of transcription, DNA-dependent
- in utero embryonic development
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- nuclear speck
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- histone deacetylase binding
- transcription corepressor activity