Ube2h Gene Summary [Rat]
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein K11-linked ubiquitination and protein K48-linked ubiquitination. Predicted to act upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Orthologous to human UBE2H (ubiquitin conjugating enzyme E2 H). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube2h |
| Official Name | ubiquitin-conjugating enzyme E2H [Source:RGD Symbol;Acc:2319288] |
| Ensembl ID | ENSRNOG00000048205 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2H |
| Synonyms | 1500009C23Rik, E2-20K, E2h, E2H10, FLJ20866, GID3, LOC100361890, UBC8, UBCH, UBCH2, ubiquitin-conjugating enzyme E2H |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ube2h often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- ubiquitin-protein transferase activity
- UBCc_UEV
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Ube2h gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- peripheral arterial disease
- infection by HIV-1
- androgenic alopecia
- alcoholic liver disease
role in cell
- ubiquitination in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ube2h gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- protein polyubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- ubiquitin-protein ligase activity
- protein binding