Plekhn1 Gene Summary [Rat]
Predicted to enable phospholipid binding activity. Predicted to be involved in 3'-UTR-mediated mRNA destabilization; positive regulation of apoptotic process; and response to hypoxia. Predicted to be located in cytosol; mitochondrion; and plasma membrane. Predicted to be active in cytoskeleton and mitochondrial membrane. Orthologous to human PLEKHN1 (pleckstrin homology domain containing N1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plekhn1 |
| Official Name | pleckstrin homology domain containing N1 [Source:RGD Symbol;Acc:1311019] |
| Ensembl ID | ENSRNOG00000020295 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain containing N1 |
| Synonyms | CLPABP, pleckstrin homology domain containing, family N member 1, pleckstrin homology domain containing N1, RGD1311019 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Plekhn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- binding protein
- protein binding
- Pleckstrin homology-like domain
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- Plasma Membrane
- Mitochondria
- cytosol
- mitochondrial membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Plekhn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hypoxia
- 3'-UTR-mediated mRNA destabilization
- positive regulation of apoptotic process
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- mitochondrial membrane
- mitochondrion
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding
- protein binding
- phosphatidic acid binding