Ppp2r3c Gene Summary [Rat]
Predicted to enable metal ion binding activity. Predicted to be involved in cytoskeleton organization; lymphocyte homeostasis; and positive regulation of B cell differentiation. Predicted to act upstream of or within several processes, including activation of protein kinase activity; regulation of mitochondrial depolarization; and spleen development. Predicted to be located in several cellular components, including Golgi apparatus; actin cytoskeleton; and nuclear body. Predicted to be active in centrosome. Human ortholog(s) of this gene implicated in spermatogenic failure 36. Orthologous to human PPP2R3C (protein phosphatase 2 regulatory subunit B''gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp2r3c |
| Official Name | protein phosphatase 2, regulatory subunit B'', gamma [Source:RGD Symbol;Acc:1309207] |
| Ensembl ID | ENSRNOG00000023591 |
| Bio databases IDs | |
| Aliases | protein phosphatase 2, regulatory subunit B'', gamma |
| Synonyms | C14orf10, G4-1, G5pr, GDRM, LOC102550845, MEGD, protein phosphatase 2 regulatory subunit B''gamma, protein phosphatase 2, regulatory subunit B'', gamma, protein phosphatase 2 regulatory subunit B''γ, protein phosphatase 2, regulatory subunit B'', γ, RGD1309207, SPGF36 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppp2r3c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- serine/threonine protein phosphatase 2A regulatory subunit B''
- EF-hand domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- actin cytoskeleton
- centrosome
- Golgi Apparatus
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppp2r3c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cortical cytoskeleton organization
- regulation of antimicrobial humoral response
- spleen development
- microtubule cytoskeleton organization
- regulation of mitochondrial depolarization
- B cell homeostasis
- regulation of dephosphorylation
- positive regulation of B cell differentiation
- T cell homeostasis
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytosol
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding