Tsc22d2 Gene Summary [Rat]

Predicted to be involved in negative regulation of cell cycle. Predicted to act upstream of or within response to osmotic stress. Orthologous to human TSC22D2 (TSC22 domain family member 2). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Tsc22d2
Official Name
TSC22 domain family, member 2 [Source:RGD Symbol;Acc:1593169]
Ensembl ID
ENSRNOG00000038044
Bio databases IDs NCBI: 499624 Ensembl: ENSRNOG00000038044
Aliases TSC22 domain family, member 2
Synonyms 1810043J12RIK, 5530402M19Rik, KIAA0669, TILZ4, TILZ4a, TILZ4b, TILZ4c, TSC22 domain family member 2, TSC22 domain family, member 2
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tsc22d2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • transcription regulator
  • TSC-22/dip/bun family
  • ZIP_TSC22D-like
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • nephrosis
  • refractive error
  • gout
  • Moyamoya disease
  • androgenic alopecia
regulated by
role in cell
  • cell death
  • cell cycle progression

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Tsc22d2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • response to osmotic stress
  • negative regulation of cell cycle
  • regulation of transcription from RNA polymerase II promoter

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

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