Nat2 Gene Summary [Rat]
Enables arylamine N-acetyltransferase activity. Involved in liver development and response to thyroxine. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); contact dermatitis (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human NAT1 (N-acetyltransferase 1) and NAT2 (N-acetyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nat2 |
| Official Name | N-acetyltransferase 2 [Source:RGD Symbol;Acc:70492] |
| Ensembl ID | ENSRNOG00000049498 |
| Bio databases IDs | |
| Aliases | N-acetyltransferase 2 |
| Synonyms | N-acetyltransferase 2, N-acetyltransferase 2 (arylamine N-acetyltransferase), Nat2a |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nat2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-acetyltransferase
- N-hydroxyarylamine O-acetyltransferase
- arylamine N-acetyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- 4-biphenylamine
- 2-aminofluorene
regulates
- sulfamethazine
- 4-aminosalicylate
- 4,4'-diaminodiphenylmethane
regulated by
- poly rI:rC-RNA
- FADD
phenotypes
- Behcet's disease
- Chemical and Drug Induced Liver Injury
- Diabetic Nephropathies
- Discoid Lupus Erythematosus
- Drug-induced agranulocytosis
- Drug-Related Side Effects and Adverse Reactions
- Gallbladder Neoplasms
- Mouth Neoplasms
- Parkinson's disease
- Presbycusis
- acute myeloid leukemia
- allergic contact dermatitis
- asthma
- atopic dermatitis
- Cholangiocarcinoma
- chronic obstructive pulmonary disease
- Diabetes Mellitus
- end stage renal failure
- eye disease
- laryngeal squamous cell carcinoma
- Leukemia
- lung cancer
- lung disease
- occupational dermatitis
- oral mucosa leukoplakia
- pancreatic cancer
- precursor lymphoblastic lymphoma/leukemia
- progressive supranuclear palsy
- prostate cancer
- psoriasis
- pulmonary tuberculosis
- Senile Cataract
- systemic lupus erythematosus
- systemic scleroderma
- transitional cell carcinoma
- urinary bladder cancer
- end stage renal disease
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol