Ddx11 Gene Summary [Rat]
Predicted to enable several functions, including 5'-3' DNA helicase activity; DNA binding activity; and single-stranded RNA binding activity. Predicted to be involved in several processes, including cellular response to bleomycin; cellular response to cisplatin; and positive regulation of nucleobase-containing compound metabolic process. Predicted to be located in several cellular components, including microtubule cytoskeleton; midbody; and nuclear lumen. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Warsaw breakage syndrome. Orthologous to several human genes including DDX11 (DEAD/H-box helicase 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddx11 |
| Official Name | DEAD/H-box helicase 11 [Source:RGD Symbol;Acc:1306675] |
| Ensembl ID | ENSRNOG00000051528 |
| Bio databases IDs | |
| Aliases | DEAD/H-box helicase 11 |
| Synonyms | DEAD/H-box helicase 11 |
| Species | Rat, Rattus norvegicus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ddx11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA repair helicase (rad3)
- helicase
- helicase superfamily c-terminal domain
- DNA replication origin binding
- chromatin binding
- enzyme
- DNA dependent ATPase
- single-stranded RNA binding
- RNA dependent ATPase
- DNA binding
- DNA helicase
- helicase C-terminal domain
- triplex DNA binding
- single-stranded DNA binding
- double-stranded DNA binding
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- midbody
- nucleoplasm
- nucleoli
- spindle pole
- chromatin