Malrd1 Gene Summary [Rat]
Predicted to act upstream of or within cholesterol homeostasis and negative regulation of bile acid biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in Golgi apparatus. Orthologous to human MALRD1 (MAM and LDL receptor class A domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Malrd1 |
| Official Name | MAM and LDL receptor class A domain containing 1 [Source:RGD Symbol;Acc:2320868] |
| Ensembl ID | ENSRNOG00000052916 |
| Bio databases IDs | |
| Aliases | MAM and LDL receptor class A domain containing 1 |
| Synonyms | bA265G8.2, C10orf112, DIET1, Gm13318, Gm13364, LOC100128641, LOC100652979, LOC100653216, LOC100912561, LOC101060163, LOC729195, MAM and LDL receptor class A domain containing 1, RGD1559888, RGD1563652 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Malrd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
- Human growth factor-like EGF
- LDLa
- protein binding
- MAM domain, meprin/A5/mu
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- COVID-19
- bile acid diarrhea
- pneumonia
- progression free survival
- lung adenocarcinoma
- lung adenocarcinoma formation
- ankylosing spondylitis
- obsessive-compulsive disorder
- postmenopausal osteoporosis
regulates
- cholesterol
- bile acid
- FGF19
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Malrd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of bile acid biosynthetic process
- cholesterol homeostasis
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- Golgi apparatus