Lipn Gene Summary [Rat]
Predicted to enable hydrolase activity, acting on ester bonds. Predicted to be involved in lipid catabolic process. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPN (lipase family member N). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lipn |
| Official Name | lipase, family member N [Source:RGD Symbol;Acc:1560354] |
| Ensembl ID | ENSRNOG00000057173 |
| Bio databases IDs | |
| Aliases | lipase, family member N |
| Synonyms | ARCI8, bA186O14.3, LI4, lipase family member N, lipase, family member N, LIPL4, RGD1560354 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lipn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha/beta hydrolase fold
- alpha/beta hydrolases
- Serine aminopeptidase, S33
- Partial alpha/beta-hydrolase lipase region
- enzyme
- lipoprotein lipase
Pathways
Biological processes and signaling networks where the Lipn gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lamellar ichthyosis
- autosomal recessive congenital ichthyosis type 8
regulated by
- tretinoin
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lipn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid catabolic process
- cornification
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- lipoprotein lipase activity