Lefty2

Predicted to enable cytokine activity. Predicted to be involved in anterior/posterior axis specification. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human LEFTY1 (left-right determination factor 1) and LEFTY2 (left-right determination factor 2). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lefty2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Lefty2 gene in rat plays a role, providing insight into its function and relevance in health or disease.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.