Ready to learn more? Here is a selection of publications, webinars and other resources that demonstrate the power of QIAGEN's LNA-enhanced functional analysis tools.

Resources

Download our functional analysis brochure to learn more about our functional analysis portfolio.

Watch a webinar: "Competing RNAs analyzed with LNA-enhanced functional tools: A non-coding function of TYRP1 mRNA promotes melanoma growth" by Dr. Marie-Dominique Galibert, Rennes University.

Application stories

Prof. Thomas Thum and Dr. Janika Viereck work at the Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Germany. They recently published a Science Translational Medicine paper on the lncRNA Chast and its involvement in cardiac remodelling. They have been using Antisense LNA GapmeRs in vivo to silence Chast and reverse cardiac disease. Read more

Prof. Jean-Christophe Marine and Dr. Eleonora Leucci work at the Laboratory for Molecular Cancer Biology, K.U. Leuven in Belgium. They recently published a Nature paper showing that melanoma cancer cells are addicted to the lncRNA SAMSSON. They have been using Antisense LNA GapmeRs to silence the lncRNA SAMSSON and suppress tumor growth. Read more

Selected publications:

miRCURY LNA in vivo Power Target Site Blockers

Messina, A. et al. (2016) A microRNA switch regulates the rise in hypothalamic GnRH production before puberty. Nature Neuroscience, 19, 835. (Link)
Lippi, G. et al. (2016) MicroRNA-101 regulates multiple developmental programs to constrain excitation in adult neural networks. Neuron, 92:6, 1337–1351. (Link)
Gilot, D. et al. (2017) A non-coding function of TYRP1 mRNA promotes melanoma growth. Nature Cell Biology, 19, 1348. (Link)
Sonneville, F. et al. (2017) MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology. Nature communications, 8:1, 710. (Link)

miRCURY LNA in vivo miRNA inhibitors

Kornfeld, J.-W. et al. (2013) Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b. Nature, 494, 111. (Link)
Boon, R. A. et al. (2013) MicroRNA-34a regulates cardiac ageing and function. Nature, 495, 107. (Link)
Sene, A. et al. (2013) Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration. Cell metabolism, 17:4, 549–561. (Link)
Son, D. J. et al. (2013) The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis. Nature communications, 4, 3000. (Link)
Seeger, T. et al. (2014) Long-term inhibition of miR-21 leads to reduction of obesity in db/db mice. Obesity, 22:11, 2352–2360. (Link)
Sassi, Y. et al. (2017) Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling. Nature communications, 8:1, 1614. (Link)

miRCURY LNA GapmeRs

Xing, Z. et al. (2014) lncRNA directs cooperative epigenetic regulation downstream of chemokine signals. Cell, 159:5, 1110–1125. (Link)
Viereck, J. et al. (2016) Long noncoding RNA Chast promotes cardiac remodeling. Science Translational Medicine, 8:326, 326ra22. (Link)
Adriaens, C. et al. (2016) p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. Nature Medicine, 22, 861. (Link)
Lin, A. et al. (2017) The LINK-A lncRNA interacts with PtdIns(3,4,5)P(3) to hyperactivate AKT and confer resistance to AKT inhibitors. Nature cell biology, 19:3, 238–251. (Link)