GeneGlobe ID: SMH-008AA | Cat. No.: 337021 | qBiomarker Somatic Mutation PCR Arrays
qBiomarker™ Somatic Mutation PCR Array Human Receptor Tyrosine Kinase (RTK) Pathways (Panel I)
Product Specification
PCR plate and master mix
Target List
EGFR
These assays detect the most frequently identified EGFR mutations, which include P-loop and activation loop point mutations, kinase domain deletions, and insertion mutations.
ERBB2
The most frequently identified activating ERBB2 mutations cluster in its kinase domain.
FGFR2, FGFR3
The most frequently identified FGFR mutations occur in their kinase domains and non-kinase extracellular domains such as the hinge regions and IgG-like domains. Some of the somatic mutations also correspond to congenital SNPs involved in genetic diseases.
FLT3
The most frequently identified FLT3 variants include point mutations, insertions and deletions in the juxtamembrane and activation loop domains of the protein.
KIT
The most frequently identified KIT gain-of-function mutations include the D816V point mutation; point mutations in, and a deletion of, exon 11 (the juxtamembrane domain); an exon 9 insertion; as well as exon 13 point mutations.
MET
The most frequently identified MET gain-of-function point mutations lie in its tyrosine kinase and juxtamembrane domains.
PDGFRA
The most frequently identified PDGFRA gain-of-function variants include deletions, insertions, and point mutations in the regions of p.D842-S847 and p.R554-E571 as well as the specific point mutations p.N659Y and p.T674I.
Product Resources
File Size: 140.55 KBLanguage: English
Resources
Supplementary Protocols (7)
Download Files (1)
Safety Data Sheets (1)
Instrument Technical Documents (2)
Performance Data (3)
Kit Handbooks (1)
White Papers (1)
Articles (1)
Application Notes (1)
Certificates of Analysis (1)
Introducing the qBiomarker™ Somatic Mutation PCR Array Human Receptor Tyrosine Kinase (RTK) Pathways (Panel I), a cutting-edge addition to our qBiomarker Somatic Mutation PCR Arrays lineup, specifically designed for Mutation/Variant Detection applications. This premium product offers unparalleled performance for researchers working with Human models. Leveraging advanced technology, the qBiomarker™ Somatic Mutation PCR Array Human Receptor Tyrosine Kinase (RTK) Pathways (Panel I) facilitates accurate and reliable results, making it an indispensable tool for your scientific investigations. Whether you're conducting Mutation/Variant Detection, or any other sophisticated analyses, this product from our qBiomarker Somatic Mutation PCR Arrays collection ensures optimal efficiency and reproducibility for Human studies. Embrace the future of research with qBiomarker™ Somatic Mutation PCR Array Human Receptor Tyrosine Kinase (RTK) Pathways (Panel I) and elevate your work to new heights.