qBiomarker™ Somatic Mutation PCR Array Human Acute Myeloid Leukemia
GeneGlobe ID: SMH-045AA | Cat. No.: 337021 | qBiomarker Somatic Mutation PCR Arrays
Product Specification
PCR plate and master mix
Target List
ASXL1
Most frequently observed mutations in this gene are C-terminal truncations that lose the interaction domain with RARA, the poly-serine region, or the atypical PHD-type domain. Other truncations also lose part of the NCOA1 interaction domain and a glycine-rich region.
DNMT3A
Mutations are frequently observed in the domain conserved among S-adenosylmethionine-dependent methyltransferases superfamily members.
FLT3
The most frequently identified FLT3 variants include point mutations, insertions and deletions in the juxtamembrane and activation loop domains of the protein.
IDH1
Most of these mutations abolish magnesium binding and alter the enzyme's activity to convert alpha-ketoglutarate into R(-)-2-hydroxyglutarate instead of isocitrate into alpha-ketoglutarate.
IDH2
These mutations all lie in the substrate binding domain, and one (p.R140Q) is associated with D-2-hydroxyglutaric aciduria.
KIT
The most frequently identified KIT gain-of-function mutations include the D816V point mutation; point mutations in, and a deletion of, exon 11 (the juxtamembrane domain); an exon 9 insertion; as well as exon 13 point mutations.
NPM1
NPM1 encodes a phosphoprotein that shuttles between the nucleus and the cytoplasm and is thought to be involved in regulation of the ARF/p53 pathway. A number of gene fusion events with NPM1 have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia.
NRAS
The mutation assays detect the most important NRAS variants, all found in codons 12, 13, and 61.
RUNX1
RUNX1 is the alpha subunit of the core binding factor that is thought to be involved in normal hematopoiesis. Chromosomal translocations involving this gene have been associated with several types of leukemia.
TET2
The most common variants of this gene are C-terminal truncations missing its two glutamine-rich regions, all of its metal binding site residues, and a phosphoserine and a phosphotyrosine site.
WT1
The WT1 transcription factor plays an essential role in normal urogenital system development. A small subset of patients with Wilm's tumors contains mutations in this gene.
Product Resources
File Size: 140.13 KBLanguage: English
Resources
Download Files (1)
Kit Handbooks (1)
Performance Data (3)
Protocols (8)
User Manuals (2)
White Papers (1)
Safety Data Sheets (1)
Certificates of Analysis (1)
Introducing the qBiomarker™ Somatic Mutation PCR Array Human Acute Myeloid Leukemia, a cutting-edge addition to our qBiomarker Somatic Mutation PCR Arrays lineup, specifically designed for Mutation/Variant Detection applications. This premium product offers unparalleled performance for researchers working with Human models. Leveraging advanced technology, the qBiomarker™ Somatic Mutation PCR Array Human Acute Myeloid Leukemia facilitates accurate and reliable results, making it an indispensable tool for your scientific investigations. Whether you're conducting Mutation/Variant Detection, or any other sophisticated analyses, this product from our qBiomarker Somatic Mutation PCR Arrays collection ensures optimal efficiency and reproducibility for Human studies. Embrace the future of research with qBiomarker™ Somatic Mutation PCR Array Human Acute Myeloid Leukemia and elevate your work to new heights.