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GeneGlobe ID: UHS-5000Z | Cat. No.: | QIAseq Multimodal Panels

QIAseq Multimodal Human Pan Cancer Panel

Kit containing ALL reagents (except indexes) for multimodal (DNA and RNA) sequencing

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Product Specification

Target List

For DNA sequencing, covers all exons in all known transcripts of targeted genes based on the Human GRCh37 / hg19 genome build. For RNA sequencing, covers specific sides of specific exons of the targeted genes based on the Human GRCh38 genome build.

Bladder Cancer
ARID1ABRCA1CDKN1A (p21CIP1, WAF1)CDKN2A (P16INK4A)CHD4CTNNB1ERBB2 (HER-2, NEU)FBXW7FGFR3HRASKDM6AKRASMSH6PBRM1PIK3CA (p110-alpha)PMS2PTPRDPTPRTSMARCA4STAG2TERTTP53 (p53)TP63TSC1TSC2
Brain Cancer
ATRXBRAFCDKN2A (P16INK4A)CHEK2 (RAD53)CICCTNNB1CUX1EGFR (ERBB1)FGFR1H3-3AIDH1IDH2MAGI2NF1PIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PTCH1PTENPTPRDPTPRTSMARCA4TERTTP53 (p53)TP63TSC2
Glioblastomas​
CDK4KDR (VEGFR3)PDGFRA
Gliomas​
BRAFFGFR1FGFR3NTRK2PDGFRARAF1ROS1
Neuroblastomas​
EWSR1FLI1
Breast Cancer:
Basal (Triple-Negative) Carcinomas​
ATRBLMBRCA1BRCA2CASP8 (FLICE)CDH1 (E-Cadherin)CDKN2A (P16INK4A)EGFR (ERBB1)ERBB2 (HER-2, NEU)ERBB3FGFR1KMT2CKRASMED12MSH6PIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PMS2PTENRAD51CRB1SMARCA4TP53 (p53)XRCC2
Ductal Carcinomas​
AKT1APCATMATRBRCA1BRCA2CDH1 (E-Cadherin)CDKN2A (P16INK4A)EGFR (ERBB1)ERBB2 (HER-2, NEU)FANCCFGFR2GATA3GEN1HOXB13KMT2CKRASMED12MLH1MSH2NF1PALB2PIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PTENRAD51DSMAD4 (MADH4)STK11 (LKB1)TP53 (p53)
ER-Positive & PR-Positive Carcinomas​
ACVR1BAKT1APCCBFBCDH1 (E-Cadherin)ERBB3KRASMLH1PIK3CA (p110-alpha)PTENTP53 (p53)
HER-Positive Carcinomas​
APCARBMPR1A (ALK3)CASP8 (FLICE)CDH1 (E-Cadherin)CDK4KMT2CMLH1MSH6NCOR1NF1PALB2PIK3CA (p110-alpha)RAD50SMAD4 (MADH4)STK11 (LKB1)TP53 (p53)
Lobular Carcinomas​
AKT1ATRCDH1 (E-Cadherin)ERBB2 (HER-2, NEU)MSH2NF1PALB2PIK3CA (p110-alpha)RB1TP53 (p53)VHL
Luminal Carcinomas​
APCCDH1 (E-Cadherin)CDKN2A (P16INK4A)GATA3KRASMAP2K4 (MKK4, JNKK1)NBNPIK3CA (p110-alpha)PTENTP53 (p53)
Other Carcinomas​
APCARATRAXIN2BARD1BRIP1CASP8 (FLICE)CDK6CHEK2 (RAD53)CTNNB1ERCC4ABRAXAS1FANCCGEN1HOXB13KRASMED12MEN1MSH6MUTYHNBNNF1PALB2PIK3CA (p110-alpha)PMS1PMS2PTENRAD50RAD51RAD51CSMAD4 (MADH4)SMARCA4STK11 (LKB1)
Other Carcinoma-Related Genes​
BAP1EP300ESR1 (ERα)MAP3K1 (MEKK1)MDM2MYCPBRM1
Other Breast Cancer Genes​
CCND1CUX1EPCAMERGFOXP1MAGI2NRG1 (HGL)NTRK3PTPRDPTPRTRUNX1T1
Cervical Cancer
ARID1ABCORBRCA1CASP8 (FLICE)CDKN2A (P16INK4A)CHD4CTNNB1CUX1ERBB2 (HER-2, NEU)FBXW7FGFR2GNASHRASKMT2CKRASMAGI2NTRK3PIK3CA (p110-alpha)PTPRDPTPRTRUNX1T1SMARCA4TP53 (p53)TSC1TSC2
Colorectal Cancer
Adenocarcinomas​
ACVR1BAKT1APCATMAXIN2BLMBMPR1A (ALK3)BRAFBRCA1BRCA2CASP8 (FLICE)CDH1 (E-Cadherin)CDK4CDKN2A (P16INK4A)CHEK2 (RAD53)CTNNA1CTNNB1EGFR (ERBB1)EP300EPCAMERBB2 (HER-2, NEU)FBXW7FGFR3FLCNGREM1KIT (CD117)KRASMAP2K4 (MKK4, JNKK1)METMLH1MSH2MSH3MSH6MUTYHNRASPALB2PIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PMS1PMS2POLD1POLEPTENRETSMAD2 (MADH2)SMAD4 (MADH4)SRCSTK11 (LKB1)TCF7L2TGFBR2TP53 (p53)ERBB2 (HER-2, NEU)FLT1 (VEGFR1)NTRK1NTRK3
Other Colorectal Cancers​
APCBRAFBRCA2CDKN2A (P16INK4A)CTNNB1FBXW7KRASNRASPIK3CA (p110-alpha)SMAD4 (MADH4)STK11 (LKB1)TCF7L2TP53 (p53)
Other Colorectal Cancer Genes​
CTNNA1GNASHRASPALB2PMS2PTPRDPTPRTRNF43RUNX1T1SMARCA4SRCTSC2
Lynch Syndrome​
MSH2
Gastric Cancer
ARID1ABRAFCDH1 (E-Cadherin)CTNNB1CUX1EPHA5ERBB2 (HER-2, NEU)FGFR1FGFR2GNASKIT (CD117)KRASMAGI2METMLH1NRG1 (HGL)NTRK3PDGFRAPTPRDPTPRTRUNX1T1SLIT2SMARCA4TP53 (p53)TSC2CSF1RERBB2 (HER-2, NEU)
Leukemia
Acute Lymphoblastic Leukemia (ALL)​
ASXL2ATMBRAFCALRCDKN2A (P16INK4A)CREBBP (CBP)CRLF2 (TSLPR)CSF3R (GM-CSFR)CTCFEGFR (ERBB1)EP300FBXW7GATA2HNRNPKHRASIL7RKDM6AKDR (VEGFR3)KMT2CMAP2K1MLH1MSH2MSH6NOTCH1NTRK3PAX5PDGFRAPMS2PTENSMARCB1ABL1CSF1REWSR1FGFR1FLT3JAK2KMT2AMLLT3MYCNOTCH1PDGFRB
Acute Myeloid Leukemia (AML)​
ASXL1ATMBCORBCORL1BIRC3 (c-IAP2)BRAFCALRCARD11CDKN2A (P16INK4A)CEBPACHEK2 (RAD53)CREBBP (CBP)CSF1RCSF3R (GM-CSFR)CTCFDAXXDDX41DNMT1EP300FLT3GATA1GATA2HNRNPKIDH1IDH2IKZF1IL7RJAK1JAK3KDM6AKDR (VEGFR3)KIT (CD117)KMT2AKMT2CKRASMAP2K1MPLMSH6MYCNBNANKRD26NOTCH1NPM1NRASNSD1NTRK3PDGFRAPHF6PTENPTPN11RAD21RUNX1 (AML1)SMARCB1SMC1ASMC3SRSF2STAG2U2AF1WT1ABL1ALKERGFGFR1JAK2KMT2AMLLT3NTRK3PDGFRAPDGFRB
Chronic Lymphocytic Leukemia (CLL)​
BIRC3 (c-IAP2)BLMBRAFCALRCHEK2 (RAD53)CSF3R (GM-CSFR)KLHL6KMT2CMAP2K1NBNNTRK3TERTMYCNOTCH1
Chronic Myeloid Leukemia (CML)​
ABL1CALRCDKN2A (P16INK4A)CEBPACREBBP (CBP)CSF1RCSF3R (GM-CSFR)FBXW7GATA2KDM6AMSH2MSH6RB1SMC1ATP53 (p53)ABL1JAK2PDGFRB
Chronic Myelomonocytic Leukemia (CMML)​
CALRCEBPACSF1RCSF3R (GM-CSFR)HRASKMT2CSRSF2KMT2A
Chronic Neutrophilic Leukemia (CNL)​
CALRCSF3R (GM-CSFR)
Other Leukemia​
ABL1ERGEWSR1JAK2KMT2AMYCNOTCH1TP53 (p53)
Liver Cancer
CTNNB1CUX1EPHA5ERGESR1 (ERα)FGFR2FOXP1HNF1AIKZF1INPP4BMAGI2NRG1 (HGL)NTRK2NTRK3PAK3PAX5PTPRDPTPRTRUNX1T1SLIT2SMARCA4TCF7L2TP53 (p53)TP63TSC2ERBB2 (HER-2, NEU)FGFR2
Lung Cancer
Non-Small Cell Lung Cancers (NSCLC)​
ALKAMER1APCATMBRAFCDKN2A (P16INK4A)CTNNB1EGFR (ERBB1)ERBB2 (HER-2, NEU)FGFR3HRASJAK2KRASMETNF1NFE2L2NRASNTRK2NTRK3PDGFRAPIK3CA (p110-alpha)PIK3CGPTENRB1RETSMARCA4STK11 (LKB1)TNFAIP3TP53 (p53)ALKEGFR (ERBB1)EML4FGFR1FGFR3FGFR4KIF5BMETNRG1 (HGL)NTRK1NTRK3RETROS1
Small Cell Lung Cancer​
ALKAMER1ARID1AATMCDKN2A (P16INK4A)CREBBP (CBP)CTNNB1DDR2EGFR (ERBB1)EPHA5ERBB4FBXW7FGFR1HRASKDR (VEGFR3)KIT (CD117)KMT2DKRASLRP1BMETMYCNF1NOTCH1NTRK1NTRK2NTRK3PIK3CA (p110-alpha)PIK3CGPIK3R1 (p85-ALPHA)PTENPTPRDRB1RBM10RETRIT1ROS1RUNX1T1SETD2SMARCA4TNFAIP3TP53 (p53)
Adenocarcinomas​
AKT1ALKAMER1APCARID1AATMBAP1BRAFCDKN2A (P16INK4A)CDKN2B (p15INK4b)CREBBP (CBP)CTNNB1DDR2EGFR (ERBB1)EPHA5ERBB2 (HER-2, NEU)ERBB4FBXW7FGFR1FGFR2FGFR3HRASJAK2KDR (VEGFR3)KEAP1KIT (CD117)KMT2DKRASLRP1BMAP2K1MDM2METMGAMLH1MYCNF1NFE2L2NOTCH1NRASNTRK1NTRK2NTRK3PDGFRAPIK3CA (p110-alpha)PIK3CGPIK3R1 (p85-ALPHA)PIK3R2 (p85-BETA)PTENPTPRDRB1RBM10RETRIT1ROS1RUNX1T1SETD2SMAD4 (MADH4)SMARCA4SOX2STK11 (LKB1)TNFAIP3TP53 (p53)TSC1U2AF1ALKBRAFEML4ERBB2 (HER-2, NEU)FGFR2FGFR3KIF5BMETNRG1 (HGL)NTRK1NTRK2RETROS1RPS6KB1
Other Adenocarcinomas​
BRAFCDKN2A (P16INK4A)CREBBP (CBP)DDR2EGFR (ERBB1)ERBB2 (HER-2, NEU)KRASNF1STK11 (LKB1)TP53 (p53)ALKEML4KIF5BNRG1 (HGL)ROS1
Squamous Cell Carcinomas (SCC)​
AKT1ALKAMER1APCARID1AATMBRAFCDKN2A (P16INK4A)CDKN2B (p15INK4b)CREBBP (CBP)CTNNB1DDR2EGFR (ERBB1)EPHA5ERBB2 (HER-2, NEU)ERBB4FBXW7FGFR1FGFR2FGFR3HRASJAK2KDR (VEGFR3)KEAP1KIT (CD117)KMT2DKRASLRP1BMAP2K1MDM2METMGAMLH1MYCNF1NFE2L2NOTCH1NRASNTRK1NTRK2NTRK3PDGFRAPIK3CA (p110-alpha)PIK3CGPIK3R1 (p85-ALPHA)PIK3R2 (p85-BETA)PTENPTPRDRB1RBM10RETRIT1ROS1RUNX1T1SETD2SMAD4 (MADH4)SMARCA4STK11 (LKB1)TNFAIP3TP53 (p53)TSC1U2AF1ALKEML4ERBB2 (HER-2, NEU)FGFR2FGFR3KIF5BKIT (CD117)NRG1 (HGL)RET
Large Cell Carcinomas​
BRAFCDKN2A (P16INK4A)DDR2EGFR (ERBB1)EPHA5FGFR1FGFR3HRASKEAP1KRASNRASNTRK1NTRK3PIK3CA (p110-alpha)STK11 (LKB1)TP53 (p53)
Other Carcinomas​
ARID1ACREBBP (CBP)CTNNB1DDR2EGFR (ERBB1)HRASKIT (CD117)KRASNRASPIK3CA (p110-alpha)STK11 (LKB1)TP53 (p53)ALKEGFR (ERBB1)EML4KIF5BRETROS1
Other Lung Cancer Genes​
CTNNB1KRASPIK3CA (p110-alpha)PTPRTTP53 (p53)TSC2
Inflammatory Myofibroblastic Tumors​
ALKEML4ROS1
Melanoma
BRAFCDKN2A (P16INK4A)CTNNB1CUX1FGFR2GNA11GNAQGRIN2AIKZF1KIT (CD117)MAGI2MAP2K1NF1NRASNTRK3PDGFRAPIK3CA (p110-alpha)PTENPTPRDPTPRTRUNX1T1SMARCA4TP53 (p53)TP63TSC2
Myeloid Neoplasms
Multiple Myeloma​
ATMBCL6BCRBIRC3 (c-IAP2)BRAFCDKN2A (P16INK4A)CEBPAEGFR (ERBB1)FBXW7HRASKDM6AMYCNOTCH1PTENSH2D1ASMARCB1
Myelodysplastic Syndromes (MDS)​
ATRXCALRCDKN2A (P16INK4A)CEBPACSF1RCSF3R (GM-CSFR)EP300GNASHRASKDM6AKMT2AKMT2CRAD21RB1SETBP1SMC3SRSF2STAG2U2AF1XPO1ZRSR2ABL1ALKERGFGFR1JAK2KMT2APDGFRB
Myelofibrosis (MF)​
CALRCHEK2 (RAD53)CSF1RIDH1IDH2SRSF2
Myeloid Malignancies​
CBLDNMT3AEEDETV6EZH2SUZ12TET2TP53 (p53)
Myeloproliferative Neoplasms (MPN)​
ABL1ASXL1CALRCSF1RJAK2JAK3KAT6AKRASMPLNF1NRASRB1SETBP1SF3B1SH2B3SRSF2STAG2
Other Myeloid Neoplasms​
ABL1ASXL1BRAFCALRCDKN2A (P16INK4A)CEBPADNMT3AETV6EZH2FBXW7FLT3GATA2HRASIDH1IDH2JAK2KIT (CD117)KMT2CKRASMAGI2MPLMSH6MYD88NPM1NTRK3PTENRUNX1 (AML1)SF3B1SRSF2TET2TP53 (p53)WT1
Other Myeloid Neoplasm Genes​
BRCA1BRCA2CUX1FASMYD88STAT3TERC
Myeloproliferative Neoplasms​
ABL1FGFR1FLT3JAK2PDGFRAPDGFRB
NUT Midline Carcinoma
NUTM1
Ovarian Cancer
ARID1ABRAFBRCA1BRCA2CDKN2A (P16INK4A)CTNNB1CUX1DICER1EPHA5ERGFOXL2FOXP1KRASMAGI2NRG1 (HGL)NTRK3PAX5PDGFRAPIK3CA (p110-alpha)PTPRDPTPRTRUNX1T1SMARCA4TP53 (p53)TP63AXLBRCA1BRCA2
Pancreatic Cancer
ANKRD11ARCDKN2A (P16INK4A)CTNNB1CUX1EPHA5ERBB4ERGESR1 (ERα)FOXP1GNASIKZF1KRASMAGI2NRG1 (HGL)NTRK2NTRK3PTPRDPTPRTRUNX1T1SLIT2SMAD4 (MADH4)SMARCA4TCF7L2TP53 (p53)
Adenocarcinomas​
AKT3BRAFERGETV1ETV4ETV5PIK3CA (p110-alpha)RAF1TMPRSS2
Carcinomas​
BRAFRAF1
Prostate Cancer
ARCTNNB1CUX1EPHA5ERBB4ERGESR1 (ERα)FGFR2FOXP1GRIN2AIKZF1INPP4BMAGI2NRG1 (HGL)NTRK2NTRK3PAX5PTPRDPTPRTRAD51BRUNX1T1SMARCA4SPOPTCF7L2TP53 (p53)
Adenocarcinomas​
AKT3ARAXLBRAFERGETV1ETV4ETV5FLT1 (VEGFR1)PIK3CA (p110-alpha)RAF1TMPRSS2
Carcinomas​
ERGETV1TMPRSS2
Other Prostate Cancers​
ERGTMPRSS2TP53 (p53)
Sarcoma
ALKAPCBRAFCDK4CTNNB1ETV6EWSR1FOXO1GLI1HRASKIT (CD117)KRASMDM2MYOD1NAB2NF1PAX3PAX7PDGFRAPDGFRBSDHBSDHCSMARCB1TFE3TP53 (p53)
Askins Tumors​
ERGEWSR1FLI1
Biphenotypic Sarcomas with Myogenic & Neural Differentiation​
EWSR1FLI1PAX3
Clear Cell Sarcomas​
EWSR1FLI1
Congenital (Infantile) Fibrosarcomas​
METNTRK3
Desmoplastic Small Round Cell Tumors​
ERGEWSR1FLI1
Ewing's Sarcomas​
ERGETV1ETV4EWSR1FLI1
Fibrosarcomas​
BRAFEWSR1NTRK1
Myofibroblastic Sarcomas​
ALKNTRK1ROS1
Rhabdomyosarcomas​
EWSR1FLI1PAX3PAX7
Small Round Cell Tumors​
ERGETV1EWSR1FLI1PAX3
Undifferentiated; Unclassified or Other Sarcomas​
ERGETV4EWSR1FGFR1FLI1PAX3
Thyroid Cancer
BCORBRAFCDKN2A (P16INK4A)CTNNB1CUX1DICER1FGFR1GNASHRASKRASMEN1NF2NRASPBRM1PIK3CA (p110-alpha)PTPRDRBM10RETSMARCA4TERTTP53 (p53)TSC1TSC2TSHRVEGFA
Adenoma-Nodule-Goitre​
PPARGRET
Anaplastic Carcinomas​
ALKRET
Papillary Carcinomas​
ALKBRAFEML4NTRK1NTRK3PPARGRET
Oncogenes
ABL1AKT1AKT2ALKARBCL2BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BRAFCARD11CASP8 (FLICE)CBLCDK4CRKLCRLF2 (TSLPR)CSF1RCTNNB1DNMT3AEGFR (ERBB1)ERBB2 (HER-2, NEU)ESR1 (ERα)ETS1EZH2FGFR2FGFR3FLT3FOXL2GATA2GNA11GNAQGNASH3-3AHGFH3C2HRASIDH1IDH2IKBKEJAK1JAK2JAK3JUNKIT (CD117)KRASMAP2K1MCL1MDM2MED12METMPLMYBMYCMYCNMYD88NFE2L2NFKBIA (IκBα, MAD3)NRASPDGFRAPIK3CA (p110-alpha)PPP2R1APTPN11RAF1RARARELRETROS1RUNX1 (AML1)SETBP1SF3B1SMOSPOPSRCSRSF2STAT3TSHRU2AF1
Tumor Suppressor Genes
ACVR1BAMER1APCARID1AARID1BARID2ARID5BASXL1ASXL2ATMATRXAXIN1B2MBAP1BARD1BCORBRCA1BRCA2CDC73CDH1 (E-Cadherin)CDKN2A (P16INK4A)CDKN2B (p15INK4b)CEBPACICCREBBP (CBP)CYLDDAXXEP300FAT1FBXW7FLCNFOXP1FUBP1GATA1GATA3HNF1AKDM5CKDM6AKMT2CKMT2DMAP3K1 (MEKK1)MEN1MLH1MSH2MSH6NF1NF2NOTCH1NOTCH2NPM1PAX5PBRM1PHF6PIK3R1 (p85-ALPHA)PRDM1PTCH1PTENRB1RNF43SETD2SMAD2 (MADH2)SMAD4 (MADH4)SMARCA4SMARCB1SOCS1SOX9STAG2STK11 (LKB1)TET2TNFAIP3TP53 (p53)TSC1TSC2VHLWT1ZFHX3
Receptor Tyrosine Kinases
ALKAXLCSF1RDDR2EGFR (ERBB1)EPHA3EPHA5EPHA7EPHB1ERBB2 (HER-2, NEU)ERBB3ERBB4FGFR1FGFR2FGFR3FGFR4FLT1 (VEGFR1)FLT3FLT4 (VEGFR2)IGF1RINSRKDR (VEGFR3)KIT (CD117)METMST1R (RON)NTRK1NTRK2NTRK3PDGFRAPDGFRBRETROS1TGFBR2
Non-Receptor Tyrosine Kinases
ABL1ABL2 (ARG)BTKFYNJAK1JAK2JAK3LYNSRCSYKYES1
Epithelial-to-Mesenchymal Transition (EMT)
BRCA2CDKN2B (p15INK4b)CTNNB1ERBB2 (HER-2, NEU)HGFJAK2KIT (CD117)MCL1NF1NOTCH1SMAD4 (MADH4)SRCVHL
Tumor Metastasis
AXLERBB3HGFIRF4MAXMETNF1
Cancer Therapeutic Targets
AKT1ATMAXLBCL2BCL6BTKCHEK1CTNNB1CXCR4EPCAMGSK3BHSP90AA1JAK2MCL1MTORNOTCH1PARP1 (ADPRT1)PTCH1SMOSRCSTAT3SYKTGFBR1 (ALK5)
Angiogenesis
AKT1AKT2AKT3BTG1CASP8 (FLICE)CTNNB1EGFL7ERBB2 (HER-2, NEU)FGF1FGF2 (BFGF)FGF6FGFR2FLT1 (VEGFR1)FLT4 (VEGFR2)GATA2GREM1HOXB13JUNKDR (VEGFR3)NF1NOTCH1PDGFRAPIK3CA (p110-alpha)PTENRUNX1 (AML1)SLIT2TGFBR2TNFAIP3VEGFAVHL
Apoptosis
ABL1ABL2 (ARG)ACVR1 (ALK2)AKT1AKT2AKT3APCARAFATMAXIN1BARD1BBC3 (PUMA)BCL2BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L11BCL2L2BCL6BIRC3 (c-IAP2)BRAFBRCA1BTG1CASP8 (FLICE)CBLCDH1 (E-Cadherin)CDKN1A (p21CIP1, WAF1)CDKN1B (P27KIP1)CDKN2A (P16INK4A)CHEK2 (RAD53)CTNNA1CTNNB1CXCR4CYLDDAXXEGFR (ERBB1)EP300ERBB2 (HER-2, NEU)ERBB3ETV1FASFLT3FOXL2GATA1HGFHRASID3IGF1IGF1RIL10IRS1JUNKRASMAP2K1MAP2K4 (MKK4, JNKK1)MAPK1 (ERK2)MAPK3 (ERK1)MCL1MDM4MLH1MSH2MYCMYCNNF1NFKBIA (IκBα, MAD3)NPM1NUP93PDK1PIK3R2 (p85-BETA)PIM1PRKCIPRKDCPTENRAD21RAD50RAD51RAF1RASA1RB1RELRHOARYBPSNCAIPSOX9STAT3STK11 (LKB1)TERTTNFAIP3TOP2ATP53 (p53)TRAF2TRAF7VEGFAVHLWT1XIAP
Autophagy
AKT1BCL2BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)CASP8 (FLICE)CDKN1B (P27KIP1)CDKN2A (P16INK4A)CXCR4ESR1 (ERα)FASHSP90AA1IGF1LAMP1MTORPIK3C3 (VPS34)PIK3CGPTENRB1RPS6KB1TP53 (p53)
Cell Adhesion Molecules
ABL1ABL2 (ARG)APCCDH1 (E-Cadherin)CSF3R (GM-CSFR)CTNNA1CTNNB1DDR2EGFL7EGFR (ERBB1)EPCAMERBB2 (HER-2, NEU)FAT1FGF4GATA1JAK2KDR (VEGFR3)KELNEGR1NF1NF2NOTCH1PDGFRAPTENPTPN11PTPRSRAC1RETRHOASRCSYKTSC1
Cell Cycle
ABL1ABL2 (ARG)ACVR1 (ALK2)AKT1AKT2AKT3APCATMATRAURKAAURKBAXIN1BCL2BCRBLMBRCA1BRCA2BRD4CCND1CCND2CCND3CCNE1CDC73CDK12CDK4CDK6CDK8CDKN1A (p21CIP1, WAF1)CDKN1B (P27KIP1)CDKN2A (P16INK4A)CDKN2B (p15INK4b)CDKN2C (p18-INK4C)CENPACHEK1CHEK2 (RAD53)CREBBP (CBP)CUL3CUX1CYLDDIS3EGFR (ERBB1)EP300FBXW7FGFR2HGFHRASID3IGF1IGF2INHBAJAK2JUNKLF4KRASMAPK1 (ERK2)MAPK3 (ERK1)MDC1MDM2MDM4MEN1MLH1MYCNBNNF2NOTCH2NPM1NRASPDK1PIM1PLK2PPM1DPTENPTPRDRAD21RAD50RAD51RB1RHEBRHOASMARCA4SMARCB1SMC1ASMC3SOX2SOX9STAG1STAG2STK11 (LKB1)TCF3TERTTNFAIP3TP53 (p53)TSC1VEGFAXPO1ZFHX3
Cell Growth & Proliferation
ACVR1 (ALK2)AKT1ARBCL2BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BLMBRAFBTG1CCND1CDKN1B (P27KIP1)CDKN2A (P16INK4A)CSF1RCTNNB1CXCR4EGFR (ERBB1)ERBB2 (HER-2, NEU)EWSR1FGFR4FLT4 (VEGFR2)HGFHRASIGF1IL10INSRKRASMAPK1 (ERK2)MAPK3 (ERK1)MDM2METMPLMYCNF2NFKBIA (IκBα, MAD3)NPM1NRASPAK7PAX5PDGFRAPIK3R2 (p85-BETA)PIM1PTENRAF1RASA1SMAD3 (MADH3)SOCS1SRCSYKTGFBR2TMEM127TP53 (p53)TSHRVEGFA
Cell Migration
ACVR1 (ALK2)ARAXLBCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)CDKN1B (P27KIP1)CTNNB1EGFR (ERBB1)FGF7IGF1IL10IRS1MAP2K1MYCNFKBIA (IκBα, MAD3)PDGFRAPTENSMOSTAT3TGFBR2VEGFA
Cellular Senescence
ABL1AKT1ATMCALRCCND1CCNE1CDK4CDK6CDKN1A (p21CIP1, WAF1)CDKN1B (P27KIP1)CDKN2A (P16INK4A)CDKN2B (p15INK4b)CDKN2C (p18-INK4C)CHEK1CHEK2 (RAD53)E2F3ETS1GSK3BHRASIGF1IGF1RMAP2K1MDM2MYCNBNPIK3CA (p110-alpha)PTENRB1TBX3TERTTP53 (p53)
Cytoskeleton Regulators
EML4KIF5BPAK7SPTA1
DNA Damage & Repair
ABL1ABL2 (ARG)APCATMATRATRXAXIN2BARD1BLMBRCA1BRCA2BRIP1C11orf30CCND1CDKN1A (p21CIP1, WAF1)CHEK1CHEK2 (RAD53)EP300EPCAMERCC1ERCC2 (XPD)ERCC3 (XPB)ERCC4ERCC5ABRAXAS1FANCAFANCCFANCD2FANCEFANCFFANCGFANCIFANCLGEN1MAPK1 (ERK2)MDC1MDM2MEN1MLH1MRE11MSH2MSH3MSH6MTORMUTYHNBNNPM1PALB2PARP1 (ADPRT1)PIK3C2BPMS1PMS2POLD1POLEPRKDCRAD21RAD50RAD51RAD51BRAD51CRAD51DRAD52RAD54LRECQL4SETD2SMC1ASMC3STK11 (LKB1)TERTTP53 (p53)XIAPXRCC2
Epigenetics
ARID1AARID1BARID2ARID5BASXL1ASXL2ATRXAURKAAURKBBAP1BCORBCORL1BRD4CENPACHD2CHD4CTCFDICER1DNMT1DNMT3ADNMT3BDOT1LEEDEZH2FOXA1H3-3AH3F3BH3F3CHIST1H1CHIST1H2BDHIST1H3AH3C2HIST1H3CH3C4HIST1H3EHIST1H3FHIST1H3GHIST1H3HHIST1H3IHIST1H3JHIST2H3AHIST2H3CHIST2H3DHIST3H3IKZF1KAT6AKDM5AKDM5CKDM6AKMT2AKMT2BKMT2CKMT2DMLLT3NCOR1NSD1PBRM1PHF6PRDM1RARARUNX1T1RYBPSETBP1SETD2SMARCA4SMARCB1SMARCD1SPOPSUZ12TCF3TET1TET2TOP1
Growth Factors & Receptors
EGFR (ERBB1)ERBB2 (HER-2, NEU)ERBB3ERBB4FGF10FGF14FGF2 (BFGF)FGF23FGF5FGF8FLT1 (VEGFR1)FLT4 (VEGFR2)IGF1IGF1RIGF2KDR (VEGFR3)KIT (CD117)METPDGFRAPDGFRBVEGFA
Hormone Receptors
ARESR1 (ERα)PGRPPARGRARA
Immune Checkpoint Molecules
B2MCD274 (PD-L1)CD274 (PD-L1)CD276CD74CTLA4HLA-AHLA-BHLA-CICOSLGPDCD1 (PD1)PDCD1 (PD1)PDCD1LG2TNFRSF14VTCN1
Immune Response
ALKB2MBTKCARD11CD274 (PD-L1)CD274 (PD-L1)CD276CD79ACD79BCREBBP (CBP)CRLF2 (TSLPR)CXCR4CYLDEP300FAM46CIL7RIRF4JAK1JAK2JAK3MAP2K1MAP2K2 (MEK2)MAP3K1 (MEKK1)MCL1MYD88NFKBIA (IκBα, MAD3)PAX5PIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PTENPTPN11RELTNFAIP3TNFRSF14TP53 (p53)
Inflammatory Response
BCRCEBPACSF1RCXCR4JAK2MYD88RELTNFAIP3
Metabolism
AKT1AKT2AKT3ALOX12BASXL2DNAJB1FHFLCNHSD3B1IDH1IDH2IGF1MTORPDK1RICTORRPTORSDHASDHAF2SDHBSDHCSDHDSTK11 (LKB1)TSC2
mRNA Splicing
DHX15QKIRBM10SF3B1SHQ1SMC1ASRSF2U2AF1ZRSR2
Proteases
KELPRSS8TMPRSS2
Signal Transduction
Androgen Receptor Signaling​
ARCCND1CTNNB1DAXXEGFR (ERBB1)FOXO1IGF1PTENRB1TMPRSS2VEGFA
BCR-ABL Pathway​
ABL1BCRJAK2STAT3STAT5ASTAT5B
CREB Signaling & Targets​
BCL2BRCA1CCND1CDKN2B (p15INK4b)FGF6INHBANF1PMAIP1 (NOXA)PRKAR1ARB1STAT3
Estrogen Receptor Signaling & Targets​
BRCA1CCND1ERBB2 (HER-2, NEU)ESR1 (ERα)FOXA1HSP90AA1IGF1MYCNCOA3NCOR1PGRPTCH1RARA
Fibroblast Growth Factor Signaling​
AKT1FGF4FGF6FGFR1FGFR2FGFR3FGFR4PIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PTENPTPN11SRC
G-Protein Coupled Receptor Signaling​
AKT1GNA11GNAQGNASGRM3SMOTSHR
G-Protein Signaling​
ADGRA2ARFRP1CDKN1A (p21CIP1, WAF1)CDKN2A (P16INK4A)GPS2HRASKRASNRASPAK7RAB35RAC1RAF1RANBP2RASA1RB1RHOASRCTP53 (p53)
Growth Factor Signaling & Targets​
FRS2HRASIGF1JUNMAPK1 (ERK2)MAPK3 (ERK1)PDGFRASTAT3STAT5A
Hedgehog Signaling & Targets​
BCL2CCND1CSNK1A1ERBB4FGF9FGFR3GLI1GSK3BMAPK1 (ERK2)PTCH1SMOSUFUTP53 (p53)VEGFA
Hippo Signaling​
LATS1LATS2NF2YAP1
Hypoxia Signaling & Targets​
ATRBLMBTG1CREBBP (CBP)EP300MAP3K1 (MEKK1)METNF1PDK1PIM1SMAD4 (MADH4)TFRCVEGFAVHL
IGF Signaling​
HRASIGF1IGF1RIGF2IRS1JUNMAP2K1MAPK3 (ERK1)PTPN11RAF1RASA1
Insulin Signaling & Targets​
AKT1AKT2AKT3FOXO1INSRIRF2IRS1JUNMYD88PDPK1PIK3CA (p110-alpha)PIK3CBPIK3CDPIK3CGTP53 (p53)
JAK / STAT Signaling & Targets​
AKT1BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)CCND1CDKN1A (p21CIP1, WAF1)CREBBP (CBP)CSF1REGFR (ERBB1)FASGATA3IFNGR1IL10INSRJAK1JAK2JAK3MCL1MPLMYCPDGFRASOCS1SRCSTAT3STAT4STAT5ASTAT5B
MAP Kinase Signaling & Targets​
ARAFBRAFCCND1CCND2CCND3CCNE1CDK4CDK6CDKN1A (p21CIP1, WAF1)CDKN1B (P27KIP1)CDKN2A (P16INK4A)CDKN2B (p15INK4b)CDKN2C (p18-INK4C)CEBPAEGFR (ERBB1)HGFHRASJUNKRASMAP2K1MAP2K2 (MEK2)MAP2K4 (MKK4, JNKK1)MAP3K1 (MEKK1)MAP3K13MAP3K14MAP3K4 (MEKK4)MAPK1 (ERK2)MAPK3 (ERK1)MAXMST1MYCNRASPAK1PDGFRAPPM1DRAC1RAF1RB1RHOARIT1SOX2SRCSTAT3STK40TP53 (p53)TRAF7
MET / HGF Signaling​
HGFMET
mTOR Signaling​
AKT1AKT2AKT3EIF4EGSK3BHRASIGF1INSRIRS1MAPK1 (ERK2)MAPK3 (ERK1)MTORPDK1PDPK1PIK3C3 (VPS34)PIK3CA (p110-alpha)PIK3CBPIK3CDPIK3CGPTENRHEBRHOARICTORRPS6KA4RPS6KB1RPS6KB2RPTORSTK11 (LKB1)TMEM127TP53 (p53)TSC1TSC2VEGFA
NFκB Signaling & Targets​
AKT1BCL10BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BIRC3 (c-IAP2)CARD11CASP8 (FLICE)EGFR (ERBB1)GREM1IKBKEIL10JAK2JUNMALT1MAP3K1 (MEKK1)MYD88NFKBIA (IκBα, MAD3)RAF1RELRHOATNFAIP3TRAF2
Notch Signaling & Targets​
AXIN1CBLCCND1CCNE1CDKN1A (p21CIP1, WAF1)CREBBP (CBP)CTNNB1EP300ERBB2 (HER-2, NEU)FBXW7GATA2GLI1NOTCH1NOTCH2NOTCH3NOTCH4PAX5PPARGRUNX1 (AML1)SH2D1ASUFU
p53 Signaling & Targets​
ATMATRBBC3 (PUMA)BRCA1CDKN1A (p21CIP1, WAF1)CDKN2A (P16INK4A)CHEK1CHEK2 (RAD53)DNMT1E2F3EGFR (ERBB1)ESR1 (ERα)FASMDM2MDM4MSH2MYCPPM1DPTENRB1TP63
PI3K-AKT Signaling​
AKT1AKT2AKT3ALKAPCARBCL2BTKCBLCCND1CCND2CDH1 (E-Cadherin)CDKN2A (P16INK4A)CTNNB1CXCR4EGFR (ERBB1)ERBB2 (HER-2, NEU)FLT3FOXO1GSK3BHSP90AA1IGF1IGF1RINPP4AIRS1JAK2KDR (VEGFR3)KIT (CD117)MAPK1 (ERK2)MTORMYD88NF1NFKBIA (IκBα, MAD3)PAK1PDGFRAPDK1PDPK1PIK3C2GPIK3C3 (VPS34)PIK3CA (p110-alpha)PIK3CBPIK3CDPIK3CGPIK3R1 (p85-ALPHA)PIK3R2 (p85-BETA)PIK3R3PREX2PTENSYKTP53 (p53)VEGFA
PTEN Signaling & Targets​
AKT1CDKN1B (P27KIP1)EGFR (ERBB1)IGF1MAPK1 (ERK2)MAPK3 (ERK1)PDK1PDPK1PTENTP53 (p53)VEGFA
TGFβ / BMP Signaling & Targets​
ACVR1 (ALK2)ACVR1BBMPR1A (ALK3)CDKN1A (p21CIP1, WAF1)CDKN1B (P27KIP1)CDKN2B (p15INK4b)CREBBP (CBP)EP300GREM1ID3IGF1INHAINHBAJUNMYCRUNX1 (AML1)SMAD2 (MADH2)SMAD3 (MADH3)SMAD4 (MADH4)TGFBR1 (ALK5)TGFBR2
WNT Signaling & Target​
AMER1APCAXIN1AXIN2CCND1CCND2CDKN2A (P16INK4A)CREBBP (CBP)CTNNB1CYLDEPCAMFGF9GSK3BHNF1AJUNLATS1LATS2MED12MYCPPP2R1APPP2R2APPP6CRB1RNF43SMAD4 (MADH4)SOX2TCF7L2TP53 (p53)TSC2WISP3
Other Signal Transduction Genes​
AXLCBFBDDR2EPHA3EPHA5EPHA7EPHB1ERBB3ERRFI1EWSR1FGF19FGF3FLT1 (VEGFR1)FLT4 (VEGFR2)GABRA6GNA13GRIN2AINPP4BIRS2LMO1NTRK1NTRK2NTRK3PDGFRBPLCG2PRKCIRETROS1SOX17SPEN
Telomeres & Telomerase
ABL1AKT1ATMBCL2BLMCHEK1CHEK2 (RAD53)ERCC1ERCC4HSP90AA1IGF1KRASMEN1MSH2MSH3MYCNBNPARP1 (ADPRT1)PAX8PPARGPPP2R1APRKDCRAD50RB1RECQL4SLX4SMAD3 (MADH3)SMARCD1TERTTP53 (p53)
Transcription Factors
ABL1AKT1ARBRCA1BRCA2C11orf30CBLCDKN2A (P16INK4A)CEBPACHD4CICCREBBP (CBP)CTNNB1CUX1DAXXEGFR (ERBB1)EIF4EEP300ERGESR1 (ERα)ETS1ETV1ETV4ETV5ETV6EWSR1FBXW7FLI1FOXA1FOXL2FOXO1FOXP1FUBP1GATA1GATA2GATA3GATA4GATA6GLI1HNF1AHOXB13ID3IRF4JUNKEAP1KLF4LMO1LZTR1MAXMDM2MEF2BMEN1MITFMLLT3MYBMYCMYCLMYCNMYOD1NF1NFE2L2NKX2-1NKX3-1NOTCH1PAX5PGRPHOX2BPNRC1PPARGRARARB1RELRUNX1 (AML1)SMAD2 (MADH2)SMAD3 (MADH3)SMAD4 (MADH4)SOX10SOX17SOX2SOX9STAT3STAT5ASUFUTAF1TBX3TCEB1TCF3TCF7L2TOP1TP53 (p53)TSC1VHLWT1ZBTB2ZBTB7AZFHX3ZNF217ZNF703
Translation
EIF1AXEIF4A2
Ubiquitination
ASXL2BAP1BCORCUL3DAXXDCUN1D1GID4MDM2PRKNCOP1RNF43SNCAIPTAF1TCEB1TRAF7
Unfolded Protein Response
CALRHSP90AA1NFE2L2NPM1
Microsatellite Instability (MSI) Loci
BAT25BAT26BAT34C4BAT40D10S196D13S175D17S250D17S588D17S787D18S35D18S55D18S61D18S64D18S69D20S100D2S123D3S1029D5S107D5S346D7S519D8S87HSP110-T17MONO-27NR21NR22NR24
Bone Cancer
Askins Tumors​
ERGEWSR1FLI1
Ewing's Sarcomas​
ERGETV1ETV4EWSR1FLI1
Giant Cell Tumors​
EWSR1FLI1
Breast Cancer
Adenocarcinomas​
ERBB2 (HER-2, NEU)NOTCH1NOTCH2RPS6KB1
Carcinomas​
ESR1 (ERα)FGFR1NOTCH1NTRK3PIK3CA (p110-alpha)RAF1
Invasive Carcinomas​
CSF1RERBB2 (HER-2, NEU)KIT (CD117)PIK3CA (p110-alpha)RPS6KB1
Other Breast Cancers​
AKT3NOTCH3
Endometrial Cancer
ERBB2 (HER-2, NEU)PIK3CA (p110-alpha)
Kidney Cancer
ALKNTRK3
Lymphoma
Anaplastic Large Cell Lymphomas​
ALKMYC
Diffuse Large B Cell Lymphomas (DLBCL)​
ALKMYC
Follicular Lymphomas​
BCL2MYC
Hodgkin Lymphomas​
ALKJAK2MYC
Lymphoblastic Lymphomas​
FGFR1KMT2AMLLT3MYCNOTCH1PDGFRB
T Cell Lymphomas​
ALKFGFR1FGFR3JAK2PDGFRA
Other Cancers
ETS1
Salivary Gland Cancer
FGFR1NTRK3
Skin Cancer
Benign Melanocytic Nevus; Spitz​
ALKBRAFKIF5BRETROS1TP53 (p53)
Melanomas​
BRAFEWSR1TP53 (p53)
Soft Tissue Cancer
Desmoplastic Small Round Cell Tumors​
ERGEWSR1
Inflammatory Myofibroblastic Tumors​
ALK
Rhabdomyosarcomas​
PAX3PAX7
Sarcoma​
ETV4EWSR1
Small Round Cell Tumors​
ETV1EWSR1FLI1
Stomach Cancer
ERBB2 (HER-2, NEU)FLT1 (VEGFR1)PDGFRB
Urinary Tract Cancer
FGFR3PIK3CA (p110-alpha)
Uterine Cancer
ESR1 (ERα)PIK3CA (p110-alpha)

Product Resources

Detailed Target List for each Analyte
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Template Files (6)
Sample Sheet Multimodal UDI Set A
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Sample Sheet Multimodal UDI Set B
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Sample Sheet Multimodal UDI Set A and Set B
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Using the QIAseq Multimodal Panel Separate Targeted DNA and RNA Enrichment Template for the MiSeq Excel File
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Sample Sheet Multimodal Panel HT
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Reads Allocation Multiplex
SOFTWARE (22KB)
Brochures & Guides (4)
QIAseq Multimodal Panels Product Profile
PDF (280KB)
QIAseq Multimodal Panels – interactive product profile
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QIAseq Multimodal: The power of one
The QIAseq advantage – interactive product profile
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State-of-the-art technologies to fast-track and streamline NGS workflows
QIAseq Multimodal technology – scientific poster
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QIAseq Multimodal Analytical Technology
Kit Handbooks (2)
QIAseq Multimodal Panel Handbook
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QIAseq Multimodal Panel HT Handbook
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Supplementary Files (1)
QIAseq Pan-cancer Multimodal Panel Gene Target List
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List of gene targets for QIAseq Pan-cancer Multimodal Panel
Safety Data Sheets (1)
Safety Data Sheets
Certificates of Analysis (1)
Certificates of Analysis
Introducing the QIAseq Multimodal Human Pan Cancer Panel, a cutting-edge addition to our QIAseq Multimodal Panels lineup, specifically designed for NGS applications. This premium product offers unparalleled performance for researchers working with Human models. Leveraging advanced technology, the QIAseq Multimodal Human Pan Cancer Panel facilitates accurate and reliable results, making it an indispensable tool for your scientific investigations. Whether you're conducting NGS, or any other sophisticated analyses, this product from our QIAseq Multimodal Panels collection ensures optimal efficiency and reproducibility for Human studies. Embrace the future of research with QIAseq Multimodal Human Pan Cancer Panel and elevate your work to new heights.
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