Target List
Apoptosis
Pro-Apoptotic
ABL1AIFM1AKT1BADBAK1BAXBBC3 (PUMA)BCL10BCL2L11BIDBIKBMFBNIP3BNIP3LBRCA1CASP1 (ICE)CASP10 (MCH4)CASP14CASP2CASP3CASP4CASP6CASP8 (FLICE)CASP8AP2CD27 (TNFRSF7)CD28CD40 (TNFRSF5)CD70CDKN1A (p21CIP1, WAF1)CIDEBCRADDCYCSDAXXDDIT3 (GADD153, CHOP)DFFADIABLOFADDFAF1FASFASLG (TNFSF6)FEM1BFOXO3GADD45AHIPK2HRKIFNB1IKBKGIL18IL1BIL24LTA (TNFB)LTBRMADDMAP3K5NGFRBEX3NOD1 (CARD4)PIDD1 (PIDD)PMAIP1 (NOXA)PMLPRKCAPRKCDPYCARD (TMS1, ASC)RIPK1RIPK2RIPK3SPNTNFTNFRSF10A (TRAIL-R)TNFRSF10B (DR5)TNFRSF25 (DR3)TNFRSF8TNFRSF9TNFSF10 (TRAIL)TNFSF8TP53 (p53)TP53BP2TRADDTRAF2TRAF3
Anti-Apoptotic
AKT1BAG1BAG3BAXBCL10BCL2BCL2A1 (BFL1)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L10BCL2L2BFARBIRC2 (c-IAP1)BIRC3 (c-IAP2)BIRC5BIRC6BNIP2BNIP3BNIP3LBRAFCASP3CD27 (TNFRSF7)CD40LGCFLAR (CASPER)CIDEACSF2 (GM-CSF)DAPK1DFFAFASHRKIGF1RIL10IL2IL4IL6MCL1MYCMYD88NAIPNFKB1NFKB2NGFNGFRNOL3RASA1RIPK1RIPK2TNFTNFRSF1A (TNFR1)TNFRSF1BTNFRSF4 (OX40)TNFRSF6BTP53 (p53)TP73TRAF2XIAP
Death Domain Receptor Signaling
Caspase Inhibition
Necrosis
Other Necrosis Genes
Autophagy
Regulation of Autophagy
AKT1APOL1APPATG12ATG5BADBAK1BAXBCL2BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BECN1BIDBNIP3CASP3CASP8 (FLICE)CDKN1B (P27KIP1)CDKN2A (P16INK4A)CLN3CTSBCTSDCTSSCXCR4DAPK1DRAM1DRAM2EIF2AK3EIF4G1ERN1ESR1 (ERα)FADDFASGAAHDAC1HGSHSP90AA1HSPA8HTTIFNGIGF1INSLAMP1MAPK14 (p38ALPHA)MAPK8 (JNK1)MTORNFKB1NLRP4NOD2PIK3C3 (VPS34)PIK3CGPIK3R4PINK1PRKAA1 (AMPK)PTENRB1RPS6KB1SIRT1SNCASQSTM1TGFB1TGM2TMEM74TNFTNFSF10 (TRAIL)TP53 (p53)ULK2UVRAG