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GeneGlobe ID: RHS-009Z | Cat. No.: | QIAseq Targeted RNA Panels

QIAseq Targeted RNA Human Immuno-Oncology Panel

Kit containing wet bench-verified assays and reagents for first strand synthesis, molecular barcoding, gene-specific amplification and library preparation for targeted RNA sequencing

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Product Specification

Target List

Checkpoint Molecules
Inhibitory on Tumor Cells​
VSIRCD200CD274 (PD-L1)CD274 (PD-L1)CD48CD80CD86ITGAVITGB3LGALS9MICAMICBPDCD1LG2TNFRSF14
Stimulatory on Tumor Cells​
CD40 (TNFRSF5)CD40LGCD48CD70CD86ICOSLGTNFRSF9TNFSF14TNFSF4 (OX40L)TNFSF9
Inhibitory on T Cells​
BTLAVSIRCD160CD200R1CD28CD244CD274 (PD-L1)CD274 (PD-L1)CTLA4HAVCR2KLRC1LAG3LILRB1LILRB3PDCD1 (PD1)PDCD1 (PD1)
Stimulatory on T Cells​
CD244CD27 (TNFRSF7)CD28CD40 (TNFRSF5)CD40LGICOSTNFRSF14TNFRSF18TNFRSF4 (OX40)TNFRSF9TNFSF14TNFSF9
T Cell Receptor Genes​
CD247CD3DCD3ECD3G
Major Histocompatibility Complex I Genes​
B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-HMR1
Major Histocompatibility Complex II Genes​
CD74IFI30HLA-DMAHLA-DMBHLA-DOAHLA-DOBHLA-DPA1HLA-DPB1HLA-DQA1HLA-DQA2HLA-DQB1HLA-DQB2HLA-DRAHLA-DRB1HLA-DRB5
Other Checkpoint Molecules​
ADORA2ABTNL2CD160CD276CD44CD52CD8AHHLA2IDO1 (IDO)IDO1 (IDO)IDO2KIR3DL1KLRD1LAIR1MS4A1NRP1TIGITTMIGD2TNFRSF25 (DR3)TNFRSF8TNFSF15VTCN1
Checkpoint Blockade Therapy Biomarkers
BTLACCR7CD274 (PD-L1)CD274 (PD-L1)CD80CD8ACSF2 (GM-CSF)CTAG1ACTAG1BCXCL11 (I-TAC, IP-9)VEGFD (VEGFD)HAVCR2HLA-DRAHLA-DRB1HLA-DRB5ICOSIFNGIL10IL18IL4LAG3MKI67MLANAPDCD1 (PD1)PDCD1 (PD1)PDCD1LG2PTPRC
Immuno Regulatory Gene Signature
BRDTCCL11 (Eotaxin)CCL27CD248CD36CLCF1CSPG4CTAGE5CXCL1 (GRO1, GROa, SCYB1)CXCL14CXCL2 (GRO2, GROb, SCYB2)CXCL3EPHA2ERBB2 (HER-2, NEU)FAPFASIFNGR1IL15IL18IL1RAPIL5RA (CD125)IL6INHBAKDR (VEGFR3)KIAA0100MAGEA8MLANAMSLNMYD88PDGFRBPRTN3PSME3SYCP1TLR7TNFRSF11A (RANK)TNFRSF8TNFSF11 (RANKL)TNFSF4 (OX40L)TNFSF9TPTEVEGFC
Immuno Stimulatory Gene Signature
ACVR1BACVR2BAKAP3AMHR2ARCBLBCCDC33CCL19CCR10CCR7CD160CD19CD200CD207CD27 (TNFRSF7)CD44CD46CD5CD5LCD7CD82CREB1CRISP2CTLA4CXCL8 (IL8)DCTEPOREPPINGAGE1HLA-AIFNA1IFNA14IFNA21IL12RB1IL12RB2IL13IL13RA2IL17AIL17BIL17RBIL1R1KIR3DL3KIT (CD117)KLK3MPLODF1PIWIL2PRM1RFXAPTNFRSF17TNFSF18
Immuno Suppressive Gene Signature
CD274 (PD-L1)CD274 (PD-L1)CD276CD4VEGFD (VEGFD)HAVCR2IL10PDCD1LG2TGFB1TNFRSF10A (TRAIL-R)VEGFAVEGFBVEGFC
Tumor Antigens
CEACAM3CEACAM8CTAG1ACTAG1BDCTKLK3MLANA
Upregulated in Cancer Vaccination Response
CCL5 (RANTES)CD3DCD86CD8ACXCL10 (INP10)CXCL2 (GRO2, GROb, SCYB2)CXCL9 (MIG)GBP1GBP5GZMKICOSIRF1JAK2KLRB1KLRD1PSMB9STAT1
Immune Cell Markers
CD8 T Cells​
ABT1AES (TLE5, Groucho)APBA2 (MINT2)ARHGAP8CAMLGCD8ACD8BCDKN2AIPDNAJB1FLT3LGGADD45AGZMMKAT6AKLF9LEPROTL1LIME1MAPKAPK5-AS1PF4PPP1R2PRF1PRR5RBM3SF1SLC16A7SRSF7TBCCTHUMPD1TMC6TMEM259TSC22D3VAMP2ZFP36L2ZNF22
Th1 Cells​
APBB2APODATP9ABST2BTG3CCL4 (MIP-1B)CD38CD70CMAHPCSF2 (GM-CSF)CTLA4DGKIDOK5DPP4DUSP5EGFL6GGT1HBEGFIFNGIL12RB2IL22LRP8LRRN3LTA (TNFB)SGCBSTAT4SYNGR3TBX21ZBTB32
Th17 Cells​
IL17AIL17RARORC
Th2 Cells​
ADCY1AHI1ANK1BIRC5CDC25CCDC7CENPFCXCR6DHFREVI5GATA3GSTA4HELLSIL26LAIR2LIMA1MAFMBMICAL2NEIL3PHEXPMCHPTGISSLC39A14SMAD2 (MADH2)SNRPD1WDHD1
Follicular Helper T Cells​
B3GAT1CDK5R1CHGBCHI3L2CXCL13CXCR5HEY1HIST1H4KICA1KCNK5KIAA1324LDLRAD4MAFMAGEH1MKL2MYO6MYO7APASKPDCD1 (PD1)PDCD1 (PD1)POMT1PTPN13PVALBSH3TC1SIRPGSLC7A10SMAD1 (MADH1)ST8SIA1STK39THADATOXTSHR
Other T Helper Cell Markers​
ANP32BASF1AATF2 (CREB2)BATFBORACD28CD4DDX50FAM111AFRYLGOLGA8AICOSITM2ALRBANAP1L4NUP107PHF10PPP2R5CRPA1SEC24CSLC25A12UBE2L3YME1L1
Regulatory T Cells​
FOXP3IL2RA (CD25)KLF2LRRC32
Gamma Delta T Cells​
C1orf61CD160FEZ1
Central Memory T Cells​
AQP3ATF7IPATMCASP8 (FLICE)CDC14ACEP68CLUAP1CREBZFCYLDDOCK9FAM153BFOXP1FYB1INPP4BKLF12KMT2AMAP3K1 (MEKK1)NEFLNFATC3PCM1PCNXPDXDC2PPHC3POLR2J2PSPC1REPS1RPP38SLC7A6SNRPNST3GAL1STX16TIMM8ATRAF3IP3TXKUSP9Y
Effector Memory T Cells​
AKT3CCR2DDX17EWSR1FLI1GDPD5LTKMEFVNFATC4 (NFAT3)PRKYSND1-IT1TBC1D5TBCD
Other T Cell Markers​
BCL11BCD14CD2CD247CD3DCD3ECD3GCD5CD6CD96CHRM3-AS2GIMAP5IL2RBLCKMALNCALDPBX4PRKCQSH2D1ASKAP1THEMISTNFRSF25 (DR3)TRAT1ZAP70
Myeloid Derived Suppressor Cells​
ANPEPARG1CD33CD34FUT4IL10ITGAMTGFB1
Cytotoxic Lymphocytes​
APBA2 (MINT2)APOL3CD3ECD3GCD4CD8ACD8BCTSWDUSP2EOMESFGFBP2GNLYGZMAGZMBGZMHGZMKIFNGKLRB1KLRC1KLRC2KLRC4KLRD1KLRF1KLRK1NKG7RORARUNX3SIGIRRTBX21ZBTB16
Natural Killer Cells​
ADARB1ALDH1B1APBB2ATL2BCL2CD160CDC5LDUSP4FGF18FOXJ1FUT5FZR1GAGE2AGTF3C1GZMBIGFBP5IL21RKANK2KIR2DL1KIR2DL4KIR3DL1KIR3DL2KIR3DL3LDB3LPCAT4MADDMAPRE3MARCH6MCM3APMPPED1MRC2NCR1PDLIM4 (RIL)PLA2G6PRXPSMD4PTGDRRRADSGMS1SH2D1BSLC30A5SPNSPON2TBXA2RTCTN2TINAGL1TRPV6XCL1XCL2ZNF205
Activated Dendritic Cells​
CCL1 (I-309)CD83EBI3LAMP3OAS3
Immature Dendritic Cells​
ABCG2 (BCRP)BLVRBCARD9CD1ACD1BCD1CCD1ECH25HCLEC10ACSF1RCTNSDCSTAMPF13A1FABP4FZD2GUCA1AHS3ST2LMAN2LMMP12MS4A6ANUDT9PDXKPPARGPREPRAP1GAPSLC26A6SLC7A8SYT17TACSTD2VASH1
Myeloid Dendritic Cells​
CD1ACD1BCD1ECLEC10ACLIC2WFDC21P
Plasmacytoid Dendritic Cells​
CLEC4CIL3RA
Other Dendritic Cell Markers​
CCL13 (MCP-4)CCL17 (TARC)CCL22 (MDC)CD209HSD11B1NPR1PPFIBP2
Macrophages​
ANOS1APOEATG7BCAT1CCL7 (MCP-3)CD163CD68CD84CHI3L1CHIT1CLEC5ACOL8A2COLEC12CTSKCXCL5 (ENA-78, LIX)CYBBDNASE2BEMP1FDX1FN1GM2AGPC4MARCOME1MS4A4AMSR1PCOLCE2PPBPPTGDSRAI14SCARB2SCG5SGMS1SULT1C2
Neutrophils​
ALPLBST1CA4CD93CEACAM3CREB5CRISPLD2CSF3R (GM-CSFR)CXCR1CXCR2CYP4F3DYSFFCARFCGR3BFPR1FPR2G0S2HALHIST1H2BCHPSEKCNJ15LILRB2MEGF9MGAMMMEPDE4BS100A12 (CGRP)SIGLEC5SLC22A4SLC25A37STEAP4TECPR2TLE3TNFRSF10CVNN3
Eosinophils​
ABHD2ACACBADGRE1 (EMR1)C9orf156CATCCR3CLCCYSLTR2EPN2GALCHES1HIST1H1CHRH4IL5RA (CD125)KBTBD11KCNH2LRP5LMYO15BPTGDR2 (CRTH2, GPR44)RCOR3RNASE2RRP12SIAH1SMPD3SYNJ1TGIF1THBS1 (TSP-1)THBS4TIPARPTKTL1
Mast Cells​
ABCC4ADCYAP1CALB2CEACAM8CMA1CPA3CTSGGATA2HDCHPGDHPGDSKIT (CD117)MAOBMLPHMPOMS4A2NR0B1PPM1HPRG2PTGS1 (COX1)SCG2SIGLEC6SLC18A2 (VMAT2)SLC24A3TAL1TPSAB1TPSB2VWA5A
Other Monocytic Lineage Markers​
ADAP2CSF1RFPR3KYNUPLA2G7RASSF4TFEC
B Cells​
ABCB4BACH2BANK1BCL11ABLKBLNKCCR9CD19CD22CD72CD79ACOCHCR2DTNBFCRL2GLDCGNG7HLA-DOBHLA-DQA1IGKCKIAA0125MEF2CMS4A1OSBPL10PAX5PNOCQRSL1SCN3ASLC15A2TCL1ATNFRSF17
Regulatory T Cell Gene Signature
ACP5ACSL4ADAT2ADPRHAHCYL1ANKRD10BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)CADM1 (TSLC1)CASP1 (ICE)CCR8CD177CD274 (PD-L1)CD274 (PD-L1)CHRNA6CHST2CHST7CREB3L2CSF1 (MCSF)CSF2RBCTSCENTPD1ERI1ETV7FKBP1A (FKBP12)GCNT1GRSF1HS3ST3B1HSDL2HTATIP2IKZF2IKZF4IL1R1IL1R2JAK1KSR1LAPTM4BLAX1LAYNLEPROTLY75METTL7ANAB1NDFIP2NETO2NFAT5NFE2L3NPTNPDCD1LG2PRSS33PTPRJRNF145RRAGBSLC35F2SOCS2SSH1SSTR3TFRCTIGITTMEM184CTMPRSS6TNFRSF18TNFRSF4 (OX40)TNFRSF8TNFRSF9TRAF3VDRZBTB38
T Cell Trafficking & Infiltration into Tumors
Stimulates T Cell Trafficking & Infiltration into Tumors​
CCL5 (RANTES)CX3CL1CXCL10 (INP10)CXCL9 (MIG)ICAM1ITGB2SELESELL (LECAM-1)SELP
Inhibits T Cell Trafficking & Infiltration into Tumors​
EDNRBVEGFD (VEGFD)VEGFAVEGFBVEGFC
Other T Cell Trafficking & Infiltration into Tumors Genes​
CCL17 (TARC)CCL19CCL21 (MIP-2)CCL25 (TECK)CCL27CCL3 (MIP-1A)CCL4 (MIP-1B)CCR10CCR3CCR4CCR5CCR6CCR7CCR9CD274 (PD-L1)CD274 (PD-L1)CD44CSF2 (GM-CSF)CXCL11 (I-TAC, IP-9)CXCL13CXCR3EDN1EDN2EDN3EDNRAF2 (Thrombin)FOXP3GLG1IFNGIL1AIL1BIL6ITGA4 (CD49D)ITGALITGB1ITGB7LAMP1LAMP2LTA (TNFB)LTBLTBRMADCAM1NOS3 (eNOS)NT5EPDCD1 (PD1)PDCD1 (PD1)PDCD1LG2PTENPTPRCSELPLG (P-Selectin)TLR7TNFTNFRSF25 (DR3)TNFSF14VCAM1
T Cell Exhaustion
Upregulated in T Cell Exhaustion​
ATF4ATP1B3BST2CBLBCCL3 (MIP-1A)CCL5 (RANTES)CD200CD27 (TNFRSF7)CD69CD7CRTAMCTLA4CTSSCXCL10 (INP10)CXCL13DCTDGKEEGR2EIF3LFAM3CFASLG (TNFSF6)FDFT1FUT4GBP1GCH1HIPK2HLA-DMAHLA-DQA1ICOSIFI16IFIT3IFNGIFNGR1IL10INPP5FIRF4ITGAVITM2AKCNK5KIF3BKLK3MYO7ANDFIP1NFAT5NR4A2 (NURR1)OTUD7BPARK7PTPRJRAB27ARGS1RGS16RGS2RNF19ASH2D1ASH2D2ASIRPGSLASP100SPP1STAT3TAP1 (ABCB2)THADATIGITTMBIM6TNFRSF1BTNFRSF9TRAF3UQCRC1WARSXCL2ZC3H7A
Downregulated in T Cell Exhaustion​
FGFBP2ITGAMTNFRSF25 (DR3)
T Cell Exhaustion Transcriptional Nodes​
BATFNFATC1PRDM1TBX21
Inhibits T Cell Exhaustion​
IL2IL21IL7
Enhances T Cell Exhaustion​
IL10
Other T Cell Exhaustion Signature Genes​
ARL6IP5CST7EMP3IFITM3PCSERPINB6TRAF4
Responsiveness or Response Biomarkers
Enhanced Expression in Responsive Versus Nonresponsive Cancers​
APPCAPZBCCL4 (MIP-1B)CCL5 (RANTES)CD8ACSNK1ECTLA4CXCL10 (INP10)CXCL11 (I-TAC, IP-9)CXCL9 (MIG)EBI3EHD1GBA2GZMBHLA-DQA1IDO1 (IDO)IDO1 (IDO)IFNGINHBAIRF2NKG7ODF2PHKG2PPIFPRF1SERPINA3SHMT2SIGMAR1SMAD3 (MADH3)TIA1
Suppressed Expression in Responsive Versus Nonresponsive Cancers​
ACTG1BNIP3LCX3CL1FOXN3IFI27JAK1LTA4HNAIPOPTNPRRC2BPTENRBL2TXK
Expression Correlates with Positive Objective Response Rates​
CD274 (PD-L1)CD274 (PD-L1)CD276CTLA4HAVCR2IDO1 (IDO)IDO1 (IDO)LAG3PDCD1LG2VTCN1
Upregulated during Treatment​
CD8ACTLA4CXCL10 (INP10)EOMESGZMAGZMBICOSIFNGPRF1TNF
Regulated during Treatment​
ABRBABAM1CDACOL3A1CUL5CXCL12 (SDF1)IRF1LMO7LPGAT1MRPS27NUMA1RAD23ARBBP8SAR1BSERPINA1SMARCB1SNTB2
Cancer Cell Killing
Inhibits Cancer Cell Killing​
ARG1ARG2BTLAVSIRCD274 (PD-L1)CD274 (PD-L1)CD80HAVCR2IDO1 (IDO)IDO1 (IDO)IDO2LAG3MICAMICBPDCD1 (PD1)PDCD1 (PD1)TGFB1VTCN1
Stimulates Cancer Cell Killing​
IFNG
Antigen Processing & Presentation
Proteasome​
PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMA8PSMB1PSMB2PSMB3PSMB4PSMB5PSMB6PSMB7PSMB8PSMB9PSMB10PSMB11PSMC1PSMC2PSMC3PSMC4PSMC5PSMC6PSMD1PSMD2PSMD3PSMD4PSMD5PSMD6PSMD7PSMD8PSMD9PSMD10PSMD11PSMD12PSMD13PSMD14PSME1PSME2PSME3PSME4PSMF1PSMG1PSMG2PSMG3PSMG4
Proteases​
CTSBCTSLCTSSERAP1ERAP2IFI30LGMNLNPEPNPEPPSTPP2
Endoplasmic Reticulum & Lysosomal Transport​
ABCB9TAP1 (ABCB2)TAP2 (ABCB3)TAPBPTAPBPL
Endoplasmic Reticulum Chaperones​
CALRCANXPDIA3
Major Histocompatibility Complex I Genes​
B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-HMR1
Major Histocompatibility Complex II Genes​
CD74IFI30HLA-DMAHLA-DQA1HLA-DRAHLA-DRB1HLA-DRB5
Immune Cell Receptors & Co-Receptors​
BCAP31CD1DCD4CD8ACD8BKIR2DL1KIR2DL4KIR3DL1KIR3DL2KIR3DL3KLRC1KLRC2KLRC4KLRD1
Stimulates Antigen Presentation​
CD40 (TNFRSF5)CD40LGHMGB1IFNA1IFNA2IL1AIL1BNT5CTNF
Inhibits Antigen Presentation​
IL10IL13IL4
Interferon Gamma Response
Cell Adhesion Molecules​
ICAM1NCAM1VCAM1
Cytokines & Chemokines​
CCL2 (MCP-1)CCL5 (RANTES)IL12BIL12RB1IL18
Innate Immune Response​
CALCOCO2NLRC5
JAK / STAT Signaling​
JAK2PTPN1 (PTP1B)PTPN11PTPN2SOCS1SOCS3STAT1
Major Histocompatibility Complex I Genes​
B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-H
Major Histocompatibility Complex II Genes​
IFI30HLA-DMAHLA-DQA1HLA-DRAHLA-DRB1HLA-DRB5
Nitric Oxide Signaling​
ARG2ASS1GCH1NOS2 (iNOS)
Receptors​
FCGR1AFCGR1BIFNGR1IFNGR2PTAFRTLR3
RNA Degradation​
OAS1OAS2OAS3OASL
Transcription Factors​
IRF1IRF2IRF3IRF4IRF5IRF6IRF7IRF8IRF9PMLPPARGSP100
Other Interferon Gamma Response Genes​
CD44CIITAGBP1GBP2GBP5KYNUMT2ANUB1SNCAUBDWNT5A
Cytosolic DNA-Sensing Pathway
Nucleic Acid Binding Proteins & Nucleases​
ADARTREX1ZBP1
Inflammasome​
AIM2CASP1 (ICE)PYCARD (TMS1, ASC)
RIG-I-Like Receptor Signaling​
DDX58MAVSMB21D1TMEM173
NFκB Signaling​
CHUK (IKKα)IKBKB (IKKβ)IKBKEIKBKGNFKB1NFKBIA (IκBα, MAD3)NFKBIB (TRIP9)RELARIPK1RIPK3TBK1
Transcription Factors​
IRF3IRF7
Cytokines & Interferons​
CCL4 (MIP-1B)CCL4L2CCL5 (RANTES)CXCL10 (INP10)IFNA1IFNA14IFNA2IFNA21IFNB1IL18IL1BIL33IL6

Product Resources

icon_0041_download-s Download Target List
icon_0041_download-s Design Coverage - Covered
File Size: 76.08 KBLanguage: English
icon_0245_cc_gen_pdf-s Product Specification Sheet
File Size: 140.29 KBLanguage: English

Resources

Safety Data Sheets (1)
Safety Data Sheets
Supplementary Protocols (1)
QIAseq Targeted RNA Panel Ion Chef and Ion S5 set up Supplementary Protocol
PDF (358KB)
Instrument Technical Documents (4)
QIAseq Targeted RNA Panels Template for MiSeq
ZIP (234KB)
QIAseq Targeted RNA Panels Template for NovaSeq
ZIP (240KB)
QIAseq Targeted RNA Panels Template for Local Run Manager
ZIP (250KB)
QIAseq Targeted RNA Panels Template for NextSeq
ZIP (326KB)
Scientific Posters (1)
Explore the RNA Universe!
PDF (1MB)
Poster for download
Brochures & Guides (3)
Exploring new frontiers with next-generation sequencing
PDF (2MB)
The QIAseq advantage – interactive product profile
PDF (2MB)
State-of-the-art technologies to fast-track and streamline NGS workflows
NGS for liquid biopsy research
PDF (260KB)
Kit Handbooks (1)
QIAseq Targeted RNA Panels Handbook
PDF (980KB)
Certificates of Analysis (1)
Certificates of Analysis
Introducing the QIAseq Targeted RNA Human Immuno-Oncology Panel, a cutting-edge addition to our QIAseq Targeted RNA Panels lineup, specifically designed for NGS applications. This premium product offers unparalleled performance for researchers working with Human models. Leveraging advanced technology, the QIAseq Targeted RNA Human Immuno-Oncology Panel facilitates accurate and reliable results, making it an indispensable tool for your scientific investigations. Whether you're conducting NGS, or any other sophisticated analyses, this product from our QIAseq Targeted RNA Panels collection ensures optimal efficiency and reproducibility for Human studies. Embrace the future of research with QIAseq Targeted RNA Human Immuno-Oncology Panel and elevate your work to new heights.
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