Target List
Common Cytokines
TNF Receptor Superfamily Members​
Other Cytokines​
Chemokines & Receptors
Chemokines​
Ccl1 (I-309)Ccl11 (Eotaxin)Ccl12 (MCP-5, Scya12)Ccl17 (Tarc)Ccl19Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl20 (Mip-3a)Ccl21aCcl22 (Mdc)Ccl24 (Mpif-2, Eotaxin-2)Ccl25 (Teck)Ccl26 (Eotaxin-3)Ccl27aCcl28Ccl3 (Mip-1a)Ccl4 (Mip-1b)Ccl5 (Rantes)Ccl6Ccl7 (mcp3)Ccl8 (Mcp2)Ccl9Cx3cl1Cxcl1 (Gro1)Cxcl10 (Inp10)Cxcl11 (Itac, Ip9)Cxcl11 (Itac, Ip9)Cxcl11 (Itac, Ip9)Cxcl12Cxcl13Cxcl14Cxcl15Cxcl16Cxcl2 (Gro2)Cxcl3Cxcl5 (ENA-78, LIX)Cxcl9 (Mig)PpbpXcl1
Chemotatic Cytokine Receptors​
Toll-Like Receptor Signaling Pathway
Toll-Like Receptor Interacting Proteins & Adaptors​
Toll-Like Receptor (TLR) Signaling​
Signaling Downstream of Toll-Like Receptors​
BtkCasp8 (Flice)Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl2 (MCP-1)Chuk (IKBKA)Csf2 (GMCSF)Csf3 (Gcsf)Cxcl10 (Inp10)Elk1FaddFosIfnb1IfngIkbkb (IKKbeta)Il10Il12aIl1aIl1bIl2Il6Irak1Irak2Irf1Irf3JunLy96 (MD-2)Map2k3 (Mek3)Map3k1 (Mekk1)Map3k7 (Tak1)Mapk8 (Jnk1)Nfkb1Nfkb2Nfkbia (Iκbα, Mad3)NfrkbPparaRelRelaTbk1TnfTnfrsf1a (Tnfr1)Ube2n
Downstream Effectors of Toll-Like Receptor Signaling​
Inflammatory Response & Autoimmunity
Cytokines​
Aimp1Bmp2Ccl1 (I-309)Ccl11 (Eotaxin)Ccl17 (Tarc)Ccl19Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl20 (Mip-3a)Ccl21aCcl22 (Mdc)Ccl24 (Mpif-2, Eotaxin-2)Ccl26 (Eotaxin-3)Ccl3 (Mip-1a)Ccl4 (Mip-1b)Ccl5 (Rantes)Ccl7 (mcp3)Ccl8 (Mcp2)Cd40lgCsf1 (Mcsf)Csf2 (GMCSF)Csf3 (Gcsf)Cx3cl1Cxcl1 (Gro1)Cxcl10 (Inp10)Cxcl11 (Itac, Ip9)Cxcl11 (Itac, Ip9)Cxcl11 (Itac, Ip9)Cxcl12Cxcl13Cxcl2 (Gro2)Cxcl3Cxcl5 (ENA-78, LIX)Cxcl9 (Mig)FaslIfna2IfngIl10Il13Il15Il16Il17aIl17fIl18Il1aIl1bIl1rnIl21Il22Il23aIl27Il3Il33Il5Il6Il7Il9Lta (Tnfb)LtbMifOsmSpp1TnfTnfsf10 (Trail)Tnfsf11 (Rankl)Tnfsf13Tnfsf13bTnfsf14Tnfsf4 (Ox40l)Vegfa
Cytokine-Mediated Signaling​
Acute-Phase Response​
Chronic Inflammatory Response​
Regulation of the Inflammatory Response​
Bcl6C3C3ar1Ccl12 (MCP-5, Scya12)Ccl17 (Tarc)Ccl19Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl21aCcl22 (Mdc)Ccl24 (Mpif-2, Eotaxin-2)Ccl3 (Mip-1a)Ccl4 (Mip-1b)Ccl7 (mcp3)Ccl8 (Mcp2)Ccr1Ccr2Ccr3Ccr4Ccr7Cd14Cd40Cd40lgCxcl1 (Gro1)Cxcl10 (Inp10)Cxcl2 (Gro2)Cxcl3Cxcl5 (ENA-78, LIX)Cxcl9 (Mig)Cxcr1Cxcr2FosIl10Il10rbIl1r1Il1rapIl9Itgb2Kng1Ly96 (MD-2)Myd88Nfkb1Nos2 (iNos)Nr3c1 (GR)Ripk2SeleTirapTlr1Tlr2Tlr3Tlr4Tlr5Tlr6Tlr7Tlr9Tollip
Interferons & Receptors
Interferon Response
Interferon-Responsive Genes​
AdarBst2Casp1 (Ice)Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl5 (Rantes)Cd80CrpCxcl10 (Inp10)Ddx58 (RIG-I)Eif2ak2Ido1 (Ido)Ido1 (Ido)Ifi204Ifi27Ifi30Ifi44Ifi44lIfih1 (Mda5)Ifit1Ifit2Ifit3Ifitm1 (9-27)Ifitm2Ifitm3Il15Irf1Irf2Irf7Irf9Irgm1Irgm2Isg15Isg20Jak2Mx1Mx2Myd88NmiOas1aOas1gOas2PmlPsme1Socs1Stat1Stat2Tap1Timp1Tlr3Tlr7Tnfsf10 (Trail)
Innate & Adaptive Immune Responses
Innate Immunity​
ApcsC3Casp1 (Ice)Ccl12 (MCP-5, Scya12)Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl5 (Rantes)Cd14Cd4Cd40Cd40lgCd69Cd8aCrpCsf2 (GMCSF)Cxcl10 (Inp10)Ddx58 (RIG-I)EgfEgfrGbp2bGzmaGzmbH2-BlH2-D1H2-K1H2-M3H2-Q10H2-T10H2-T23Ifnb1Il18Il1aIl1bIl1r1Il2Irak1Irf3Irf7ItgamLy96 (MD-2)Lyz1Lyz2Mapk1 (Erk2)Mapk8 (Jnk1)Mbl2MpoMx1Myd88Nfkb1Nfkbia (Iκbα, Mad3)Nlrp3Nod1Nod2Prf1Stat1Ticam1 (Trif)Tlr1Tlr2Tlr3Tlr4Tlr5Tlr6Tlr7Tlr8Tlr9TnfTraf6
Adaptive Immunity​
Ccl12 (MCP-5, Scya12)Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl5 (Rantes)Ccr4Ccr5Ccr6Ccr8Cd4Cd40Cd40lgCd80Cd86Cd8aCrpCsf2 (GMCSF)Cxcl10 (Inp10)Cxcr3FaslFoxp3Gata3H2-Q10Icam1Ifnar1Ifnb1IfngIfngr1Il10Il13Il17aIl18Il1bIl1r1Il2Il23aIl4Il5Il6Irf3Irf7ItgamJak2Mapk8 (Jnk1)Mbl2Mx1Nfkb1Nod2Rag1RorcSlc11a1Stat1Stat3Stat4Stat6Tbx21Tlr4Tlr6Tnf
Dendritic & Antigen Presenting Cells
Dendritic Cell Differentiation​
Immune Cell Activation
T-Cell Activation​
AdaBcl2Ccl3 (Mip-1a)Ccr1Ccr2Ccr3Ccr4Ccr5Cd1d1Cd2Cd27Cd274 (Pdl1)Cd274 (Pdl1)Cd276Cd28Cd3dCd3eCd3gCd4Cd40Cd40lgCd47Cd5Cd7Cd80Cd86Cd8aCsf2 (GMCSF)Cxcr3Cxcr4Dpp4Egr1Foxp3IfngIgf1Il10Il12aIl12bIl12rb1Il12rb2Il13Il15Il18Il18r1Il1bIl2Il2ra (Cd25)Il3Il4Il5Il6Irf4Lag3LckMap3k7 (Tak1)Nck1Nos2 (iNos)Ptprc (Cd45)Ripk2Socs1Tgfb1Tlr2Tlr4Tlr9Tnfsf14Vav1
T Helper Cell Differentiation
T Helper 2 Subtype Markers​
Th1 & Th2 Responses
Other Inflammatory Response Genes​
Th17 Response
T-Cell Anergy & Immune Tolerance
TNF Superfamily Members & Their Receptors​
Apoptosis