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GeneGlobe ID: RMM-009Z | Cat. No.: | QIAseq Targeted RNA Panels

QIAseq Targeted RNA Mouse Immuno-Oncology Panel

Kit containing wet bench-verified assays and reagents for first strand synthesis, molecular barcoding, gene-specific amplification and library preparation for targeted RNA sequencing

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Product Specification

Target List

Checkpoint Molecules
Inhibitory on Tumor Cells​
4632428N05RikCd200Cd274 (Pdl1)Cd274 (Pdl1)Cd48Cd80Cd86ItgavItgb3Lgals9Mill1Mill2Pdcd1lg2Tnfrsf14
Stimulatory on Tumor Cells​
Cd40Cd40lgCd48Cd70Cd86IcoslTnfrsf9Tnfsf14Tnfsf4 (Ox40l)Tnfsf9
Inhibitory on T Cells​
4632428N05RikBtlaCd160Cd200r1Cd274 (Pdl1)Cd274 (Pdl1)Cd28Ctla4Havcr2Klrc1Lag3Pdcd1 (PD-1)Pdcd1 (PD-1)Pirb
Stimulatory on T Cells​
Cd27Cd28Cd40Cd40lgIcosTnfrsf14Tnfrsf18Tnfrsf4 (Ox40)Tnfrsf9Tnfsf14Tnfsf9
T Cell Receptor Genes​
Cd247Cd3dCd3eCd3g
Major Histocompatibility Complex Genes​
B2mCd74H2-AaH2-Ab1H2-BlH2-D1H2-DMaH2-Eb1H2-Eb2H2-K1H2-M1H2-M10.1H2-M10.2H2-M10.3H2-M10.4H2-M10.5H2-M10.6H2-M11H2-M2H2-M3H2-M5H2-M9H2-OaH2-Q1H2-Q10H2-Q2H2-Q4H2-Q6H2-T10H2-T22H2-T23H2-T24H2-T3Ifi30Mr1
Other Checkpoint Molecules​
Adora2aBtnl2Cd160Cd276Cd44Cd52Cd8aHhla1Ido1 (Ido)Ido1 (Ido)Ido2Kir3dl1Klrd1Lair1Ms4a1Nrp1TigitTmigd1Tnfrsf25 (Dr3)Tnfrsf8Tnfsf15Vtcn1
Checkpoint Blockade Therapy Biomarkers
BtlaCage1Ccr7Cd274 (Pdl1)Cd274 (Pdl1)Cd80Cd8aCsf2 (GMCSF)Ctag2Cxcl11 (Itac, Ip9)Cxcl11 (Itac, Ip9)Cxcl11 (Itac, Ip9)Vegfd (Vegfd)H2-Eb1Havcr2IcosIfngIl10Il18Il4Lag3Mki67MlanaPdcd1 (PD-1)Pdcd1 (PD-1)Pdcd1lg2Ptprc (Cd45)
Immuno Regulatory Gene Signature
2610507B11RikBrdtCcl11 (Eotaxin)Ccl27bCd248Cd36Clcf1Cspg4Ctage5Cxcl1 (Gro1)Cxcl14Cxcl2 (Gro2)Cxcl3Epha2Erbb2 (Her-2, neu)FapFasIfngr1Il15Il18Il1rapIl5ra (Cd125)Il6InhbaKdr (Vegfr2)Magea8MlanaMslnMyd88PdgfrbPrtn3Psme3Sycp1Tlr7Tnfrsf11a (Rank)Tnfrsf8Tnfsf11 (Rankl)Tnfsf4 (Ox40l)Tnfsf9TpteVegfc
Immuno Stimulatory Gene Signature
Acvr1bAcvr2bAkap3Amhr2ArCblbCcdc33Ccl19Ccr10Ccr7Cd160Cd19Cd200Cd207Cd27Cd44Cd46Cd5Cd5lCd7Cd82Creb1Crisp2Ctla4Cxcl15DctEporEppinH2-Q10Ifna14Il12rb1Il12rb2Il13Il13ra2Il17aIl17bIl17rbIl1r1Kit (Cd117)Klkb1Mpl (Tpor)Odf1Piwil2Prm1RfxapTnfrsf17Tnfsf18
Immuno Suppressive Gene Signature
Cd274 (Pdl1)Cd274 (Pdl1)Cd276Cd4Vegfd (Vegfd)Havcr2Il10Pdcd1lg2Tgfb1Tnfrsf10b (Dr5)VegfaVegfbVegfc
Tumor Antigens
AcppAfpCage1Ceacam1Ceacam10Ceacam11Ceacam12Ceacam13Ceacam14Ceacam15Ceacam18Ceacam19Ceacam2Ceacam20Ceacam3Ceacam5Ceacam9Ctag2DctEpcamGpr143Klkb1Magea1Magea3Magea4MlanaMuc1 (mucin)PmelPrameRab38Spag5Tssk6TyrTyrp1
Upregulated in Cancer Vaccination Response
Ccl5 (Rantes)Cd3dCd86Cd8aCxcl10 (Inp10)Cxcl2 (Gro2)Cxcl9 (Mig)Fam26fGbp2bGzmkIcosIl2rgIrf1Jak2Klrb1Klrd1Psmb9Stat1
Immune Cell Markers
CD8 T Cells​
Abt1Aes (Tle5, Groucho)Apba2Arhgap8CamlCd8aCd8b1Cdkn2aipDnajb1Gadd45aGzmmKat6aKlf9Leprotl1Lime1Pf4Ppp1r2Prf1Prr5Rbm3Sf1Slc16a7Srsf7TbccThumpd1Tmc6Tmem259Tsc22d3Vamp2Zeb1Zfp36l2Zfp422Zfp609Zfp729b
Th1 Cells​
Apbb2ApodAtp9aBst2Btg3Ccl4 (Mip-1b)Cd38Cd70Csf2 (GMCSF)Ctla4DgkiDok5Dpp4Dusp5Egfl6Ggt1HbegfIfngIl12rb2Il22Lrp8Lrrn3Lta (Tnfb)SgcbStat4Syngr3Tbx21Zbtb32
Th17 Cells​
Il17aIl17raRorc
Th2 Cells​
Adcy1Ahi1Ank1Birc5Cdc25cCdc7CenpfCxcr6DhfrEvi5Gata3Gsta4HellsLima1MafMbMical2Neil3PhexPmchPtgisSlc39a14Smad2Snrpd1Wdhd1
Follicular Helper T Cells​
5330417C22RikB3gat1Cdk5r1ChgbCxcl13Cxcr5Hey1Ica1Kcnk5Ldlrad4MafMageh1Mkl2Myo6Myo7aPaskPdcd1 (PD-1)Pdcd1 (PD-1)Pomt1Ptpn13PvalbSh3tc1Slc7a10Smad1St8sia1Stk39ThadaToxTshrZfp764
Other T Helper Cell Markers​
Anp32bAsf1aAtf2 (Creb2)BatfBoraCd28Cd4Ddx50Fam111aFrylIcosItm2aLrbaNap1l4Nup107Phf10Ppp2r5cRpa1Sec24cSlc25a12Ube2l3Yme1l1
Regulatory T Cells​
Foxp3Il2ra (Cd25)Klf2Lrrc32
Gamma Delta T Cells​
Cd160
Central Memory T Cells​
Aqp3Atf7ipAtmCasp8 (Flice)Cdc14aCep68Cluap1CrebzfCyldDock9Foxp1FybInpp4bKlf12Kmt2aMap3k1 (Mekk1)NeflNfatc3Pcm1PcnxPhc3Pspc1Reps1Slc7a6St3gal1Stx16Timm8a1Traf3ip3TxkUsp9y
Effector Memory T Cells​
Akt3Ccr2Ddx17Ewsr1Fli1Gdpd5LtkMefvNfatc4 (Nfat3)Tbc1d5Tbcd
Other T Cell Markers​
Bcl11bCd14Cd2Cd247Cd3dCd3eCd3gCd5Cd6Cd96Gimap5Il2rbLckMalNcaldPbx4PrkcqSh2d1aSkap1ThemisTnfrsf25 (Dr3)Trat1Zap70
Myeloid Derived Suppressor Cells​
AnpepArg1Cd33Cd34Fut4Il10ItgamTgfb1
Cytotoxic Lymphocytes​
Apba2Apol7aCd3eCd3gCd4Cd8aCd8b1CtswDusp2EomesGzmaGzmbGzmcGzmkIfngKlrb1Klrc1Klrc2Klrc3Klrd1Klrk1Nkg7RoraRunx3SigirrTbx21Zbtb16
Natural Killer Cells​
Adarb1Aldh1b1Apbb2Atl2Bcl2Cd160Cdc5lDusp4Fgf18Foxj1Fzr1Gtf3c1GzmbIgfbp5Il21rKank2Kir3dl1Kir3dl2Ldb3Lpcat4MaddMapre3March6Mcm3apMpped1Mrc2Ncr1Pdlim4 (Ril)Pla2g6PrxPsmd4PtgdrRradSgms1Slc30a5Smek1SpnSpon2Tbxa2rTinagl1Trpv6Xcl1Zfp13
Activated Dendritic Cells​
Ccl1 (I-309)Cd83Ebi3Lamp3Oas3
Immature Dendritic Cells​
Abcg2 (Bcrp)BlvrbCard9Cd1d1Cd1d2Ch25hClec10aCsf1rCtnsDcstampF13a1Fabp4Fzd2Gstt1Guca1aHs3st2Lman2lMmp12Ms4a6dNudt9PdxkPpargPrepRap1gapSlc26a6Slc7a8Syt17Tacstd2Vash1
Myeloid Dendritic Cells​
Cd1d1Cd1d2Clec10a
Other Dendritic Cell Markers​
Ccl17 (Tarc)Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl22 (Mdc)Cd209eHsd11b1Npr1Ppfibp2
Macrophages​
ApoeAtg7Bcat1Ccl7 (mcp3)Cd163Cd68Cd84Chil1Chit1Clec5aCol8a2Colec12CtskCxcl5 (ENA-78, LIX)CybbDnase2bEmp1Fdx1Fn1Gm2aGpc4MarcoMe1Ms4a4aMsr1Pcolce2PpbpPtgdsRai14Scarb2Scg5Sgms1Sult1c2Wfdc18
Neutrophils​
AlplBst1Car4Cd93Ceacam3Creb5Crispld2Csf3r (G-CSFR)Cxcr1Cxcr2Cyp4f13DysfFcgr3Fpr1Fpr2G0s2HalHist1h2bcHpseKcnj15Megf9MgamMmePde4bPirbSigleceSiglecfSlc22a4Slc25a37Steap4Tecpr2Tle3Tnfrsf10b (Dr5)Vnn3
Eosinophils​
5830415F09RikAbhd2AcacbAdgre1CatCcr3Cysltr2Epn2GalcHes1Hist1h1cHrh4Il5ra (Cd125)Kbtbd11Kcnh2Myo15bPtgdr2 (Crth2)Rcor3Rrp12Siah1aSmpd3Synj1Tgif1Thbs1 (TSP-1)Thbs4TiparpTktl1
Mast Cells​
Abcc4Adcyap1Calb2Cma1Cpa3CtsgGata2HdcHpgdHpgdsKit (Cd117)MaobMlphMpoMs4a2Nr0b1Ppm1hPrg2Ptgs1 (Cox1)Scg2Slc18a2 (Vmat2)Slc24a3Tal1Tpsab1Tpsb2Vwa5a
Other Monocytic Lineage Markers​
Adap2Csf1rFpr3KynuPla2g7Rassf4Tfec
B Cells​
Abcb4Bach2Bank1Bcl11aBlkBlnkCcr9Cd19Cd22Cd72Cd79aCochCr2DtnbFcrlbGldcGng7H2-AaIgkcMef2cMical3Ms4a1Osbpl10Pax5PnocQrsl1Scn3aSlc15a2SpibTcl1Tnfrsf17
Regulatory T Cell Gene Signature
Acp5Acsl4Adat2AdprhAhcyl1Ankrd10Bcl2l1 (Bcl-XL)Bcl2l1 (Bcl-XL)Bcl2l1 (Bcl-XL)Cadm1 (Tslc1)Casp1 (Ice)Ccr8Cd177Cd274 (Pdl1)Cd274 (Pdl1)Chrna6Chst2Chst7Creb3l2Csf1 (Mcsf)Csf2rbCtscEntpd1Eri1Fkbp1a (Fkbp12)Gcnt1Grsf1Hs3st3b1Hsdl2Htatip2Ikzf2Ikzf4Il1r1Il1r2Jak1Ksr1Laptm4bLax1LaynLeprotLy75Mettl7a1Nab1Ndfip2Neto2Nfat5Nfe2l3NptnPdcd1lg2Prss33PtprjRnf145RragbSlc35f2Socs2Ssh1Sstr3TfrcTigitTmem184cTmprss6Tnfrsf18Tnfrsf4 (Ox40)Tnfrsf8Tnfrsf9Traf3VdrZbtb38Zfp282
T Cell Trafficking & Infiltration into Tumors
Stimulates T Cell Trafficking & Infiltration into Tumors​
Ccl5 (Rantes)Cx3cl1Cxcl10 (Inp10)Cxcl9 (Mig)Icam1Itgb2SeleSelp
Inhibits T Cell Trafficking & Infiltration into Tumors​
EdnrbVegfd (Vegfd)VegfaVegfbVegfc
Other T Cell Trafficking & Infiltration into Tumors Genes​
Ccl17 (Tarc)Ccl19Ccl25 (Teck)Ccl27bCcl3 (Mip-1a)Ccl4 (Mip-1b)Ccr10Ccr3Ccr4Ccr5Ccr6Ccr7Ccr9Cd274 (Pdl1)Cd274 (Pdl1)Cd44Csf2 (GMCSF)Cxcl11 (Itac, Ip9)Cxcl11 (Itac, Ip9)Cxcl11 (Itac, Ip9)Cxcl13Cxcr3Edn1Edn2Edn3EdnraF2 (Thrombin)Foxp3Glg1IfngIl1aIl1bIl6Itga4 (Cd49d)ItgalItgb1Itgb7Lamp1Lamp2Lta (Tnfb)LtbLtbrMadcam1Nos3 (eNOS)Nt5ePdcd1 (PD-1)Pdcd1 (PD-1)Pdcd1lg2PtenPtprc (Cd45)Selplg (P-selectin)Tlr7TnfTnfrsf25 (Dr3)Tnfsf14Vcam1
T Cell Exhaustion
Upregulated in T Cell Exhaustion​
Atf4Atp1b3Bst2CblbCcl3 (Mip-1a)Ccl5 (Rantes)Cd200Cd27Cd69Cd7CrtamCtla4CtssCxcl10 (Inp10)Cxcl13DctDgkeEgr2Eif3lFam3cFaslFdft1Fut4Gbp2bGch1H2-AaH2-DMaHipk2IcosIfi204Ifit3IfngIfngr1Il10Inpp5fIrf4ItgavItm2aKcnk5Kif3bKlkb1Myo7aNdfip1Nfat5Nr4a2 (Nurr1)Otud7bPark7PtprjRab27aRgs1Rgs16Rgs2Rnf19aSh2d1aSh2d2aSlaSp100Spp1Stat3Tap1ThadaTigitTmbim6Tnfrsf1bTnfrsf9Traf3Uqcrc1WarsZc3h7aZnrf1
Downregulated in T Cell Exhaustion​
ItgamTnfrsf25 (Dr3)
T Cell Exhaustion Transcriptional Nodes​
BatfNfatc1Prdm1Tbx21
Inhibits T Cell Exhaustion​
Il2Il21Il7
Enhances T Cell Exhaustion​
Il10
Other T Cell Exhaustion Signature Genes​
Arl6ip5Cst7Emp3Ifitm3PcxSerpinb6aTraf4
Responsiveness or Response Biomarkers
Enhanced Expression in Responsive Versus Nonresponsive Cancers​
AppCapzbCcl4 (Mip-1b)Ccl5 (Rantes)Cd8aCsnk1eCtla4Cxcl10 (Inp10)Cxcl11 (Itac, Ip9)Cxcl11 (Itac, Ip9)Cxcl11 (Itac, Ip9)Cxcl9 (Mig)Ebi3Ehd1Gba2GzmbH2-AaIdo1 (Ido)Ido1 (Ido)IfngInhbaIrf2Nkg7Odf2Phkg2PpifPrf1Serpina3nShmt2Sigmar1Smad3Tia1
Suppressed Expression in Responsive Versus Nonresponsive Cancers​
Actg1Bnip3lCx3cl1Foxn3Ifi27Jak1Lta4hNaip1 (Birc1)OptnPrrc2bPtenRbl2Txk
Expression Correlates with Positive Objective Response Rates​
Cd274 (Pdl1)Cd274 (Pdl1)Cd276Ctla4Havcr2Ido1 (Ido)Ido1 (Ido)Lag3Pdcd1lg2Vtcn1
Upregulated during Treatment​
Cd8aCtla4Cxcl10 (Inp10)EomesGzmaGzmbIcosIfngPrf1Tnf
Regulated during Treatment​
AbrBabam1CdaCol3a1Cul5Cxcl12Irf1Lmo7Lpgat1Mrps27Numa1Rad23aRbbp8Serpina1bSerpina1cSerpina1dSmarcb1Sntb2
Cancer Cell Killing
Inhibits Cancer Cell Killing​
4632428N05RikArg1Arg2BtlaCd274 (Pdl1)Cd274 (Pdl1)Cd80Havcr2Ido1 (Ido)Ido1 (Ido)Ido2Lag3Mill1Mill2Pdcd1 (PD-1)Pdcd1 (PD-1)Tgfb1Tgfb2Tgfb3Vtcn1
Stimulates Cancer Cell Killing​
Ifng
Antigen Processing & Presentation
Proteasome​
Psma1Psma2Psma3Psma4Psma5Psma6Psma7Psma8Psmb1Psmb10Psmb11Psmb2Psmb3Psmb4Psmb5Psmb6Psmb7Psmb8Psmb9Psmc1Psmc2Psmc3Psmc4Psmc5Psmc6Psmd1Psmd10Psmd11Psmd12Psmd13Psmd14Psmd2Psmd3Psmd4Psmd5Psmd6Psmd7Psmd8Psmd9Psme1Psme2Psme3Psme4Psmf1Psmg1Psmg2Psmg3Psmg4
Proteases​
CtsbCtslCtssErap1Ifi30LgmnLnpepNpeppsTpp2
Endoplasmic Reticulum & Lysosomal Transport​
Abcb9Tap1Tap2TapbpTapbpl
Endoplasmic Reticulum Chaperones​
CalrCanxPdia3
Major Histocompatibility Complex Genes​
B2mCd74H2-AaH2-Ab1H2-BlH2-D1H2-DMaH2-Eb1H2-Eb2H2-K1H2-M1H2-M10.1H2-M10.2H2-M10.3H2-M10.4H2-M10.5H2-M10.6H2-M11H2-M2H2-M3H2-M5H2-M9H2-OaH2-Q1H2-Q10H2-Q2H2-Q4H2-Q6H2-T10H2-T22H2-T23H2-T24H2-T3Ifi30Mr1
Immune Cell Receptors & Co-Receptors​
Bcap31Cd1d1Cd4Cd8aCd8b1Kir3dl1Kir3dl2Klrc1Klrc2Klrc3Klrd1
Stimulates Antigen Presentation​
Cd40Cd40lgHmgb1Ifna2Il1aIl1bNt5cTnf
Inhibits Antigen Presentation​
Il10Il13Il4
Interferon Gamma Response
Cell Adhesion Molecules​
Icam1Ncam1Vcam1
Cytokines & Chemokines​
Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl5 (Rantes)Il12bIl12rb1Il18
JAK / STAT Signaling​
Jak2Ptpn1 (Ptp1b)Ptpn11Ptpn2Socs1Socs3Stat1
Major Histocompatibility Complex Genes​
B2mCd74H2-AaH2-Ab1H2-BlH2-D1H2-DMaH2-Eb1H2-Eb2H2-K1H2-M1H2-M10.1H2-M10.2H2-M10.3H2-M10.4H2-M10.5H2-M10.6H2-M11H2-M2H2-M3H2-M5H2-M9H2-OaH2-Q1H2-Q10H2-Q2H2-Q4H2-Q6H2-T10H2-T22H2-T23H2-T24H2-T3Ifi30Mr1
Nitric Oxide Signaling​
Arg2Ass1Gch1Nos2 (iNos)
Receptors​
Fcgr1Ifngr1Ifngr2PtafrTlr3
RNA Degradation​
Oas1aOas1bOas1cOas1dOas1eOas1fOas1gOas1hOas2Oas3Oasl1
Transcription Factors​
Irf1Irf2Irf3Irf4Irf5Irf6Irf7Irf8Irf9PmlPpargSp100
Other Interferon Gamma Response Genes​
Cd44CiitaGbp2Gbp2bKynuMt2Nub1SncaUbdWnt5a
Cytosolic DNA-Sensing Pathway
Nucleic Acid Binding Proteins & Nucleases​
AdarTrex1Zbp1
Inflammasome​
Aim2Casp1 (Ice)Pycard (Tms1, Asc)
RIG-I-Like Receptor Signaling​
Ddx58 (RIG-I)MavsMb21d1Tmem173
NFκB Signaling​
Chuk (IKBKA)Ikbkb (IKKbeta)IkbkeIkbkgNfkb1Nfkbia (Iκbα, Mad3)Nfkbib (Trip9)RelaRipk1Ripk3Tbk1
Transcription Factors​
Irf3Irf7
Cytokines & Interferons​
Ccl4 (Mip-1b)Ccl5 (Rantes)Cxcl10 (Inp10)Ifna14Ifna2Ifnb1Il18Il1bIl33Il6

Product Resources

icon_0041_download-s Download Target List
icon_0041_download-s Design Coverage - Covered
File Size: 78.71 KBLanguage: English
icon_0245_cc_gen_pdf-s Product Specification Sheet
File Size: 140.03 KBLanguage: English

Resources

Safety Data Sheets (1)
Safety Data Sheets
Supplementary Protocols (1)
QIAseq Targeted RNA Panel Ion Chef and Ion S5 set up Supplementary Protocol
PDF (358KB)
Instrument Technical Documents (4)
QIAseq Targeted RNA Panels Template for MiSeq
ZIP (234KB)
QIAseq Targeted RNA Panels Template for NovaSeq
ZIP (240KB)
QIAseq Targeted RNA Panels Template for Local Run Manager
ZIP (250KB)
QIAseq Targeted RNA Panels Template for NextSeq
ZIP (326KB)
Scientific Posters (1)
Explore the RNA Universe!
PDF (1MB)
Poster for download
Brochures & Guides (3)
Exploring new frontiers with next-generation sequencing
PDF (2MB)
The QIAseq advantage – interactive product profile
PDF (2MB)
State-of-the-art technologies to fast-track and streamline NGS workflows
NGS for liquid biopsy research
PDF (260KB)
Kit Handbooks (1)
QIAseq Targeted RNA Panels Handbook
PDF (980KB)
Certificates of Analysis (1)
Certificates of Analysis
Introducing the QIAseq Targeted RNA Mouse Immuno-Oncology Panel, a cutting-edge addition to our QIAseq Targeted RNA Panels lineup, specifically designed for NGS applications. This premium product offers unparalleled performance for researchers working with Mouse models. Leveraging advanced technology, the QIAseq Targeted RNA Mouse Immuno-Oncology Panel facilitates accurate and reliable results, making it an indispensable tool for your scientific investigations. Whether you're conducting NGS, or any other sophisticated analyses, this product from our QIAseq Targeted RNA Panels collection ensures optimal efficiency and reproducibility for Mouse studies. Embrace the future of research with QIAseq Targeted RNA Mouse Immuno-Oncology Panel and elevate your work to new heights.
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