Target List
Autophagy Machinery Components
Autophagic Vacuole Formation
Ambra1 (Nyw1), Atg12, Atg16l1, Atg4a, Atg4b, Atg4c, Atg4d, Atg5, Atg9a, Atg9b, Becn1, Gabarap, Gabarapl1, Gabarapl2, Irgm1, Map1lc3a, Map1lc3b, Rgs19, Ulk1, Wipi1
Vacuole Targeting
Atg4a, Atg4b, Atg4c, Atg4d, Gabarap
Protein Transport
Atg10, Atg16l1, Atg16l2, Atg3, Atg4a, Atg4b, Atg4c, Atg4d, Atg7, Atg9a, Gabarap, Gabarapl2, Rab24
Autophagosome-Lysosome Linkage
Dram1, Gabarap, Lamp1, Npc1
Ubiquitination
Atg3, Atg7, Hdac6
Proteases
Atg4a, Atg4b, Atg4c, Atg4d
Regulation of Autophagy
Co-Regulators of Autophagy & Apoptosis
Dram1, Akt1, App, Atg12, Atg5, Bad, Bak1, Bax, Bcl2, Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Becn1, Bid, Bnip3, Casp3, Casp8 (Flice), Cdkn1b (p27Kip1), Cdkn2a (p16INK4a), Cln3, Ctsb, Cxcr4, Dapk1, Eif2ak3, Fadd, Fas, Hdac1, Htt, Ifng, Igf1, Ins2, Mapk8 (Jnk1), Mtor, Nfkb1, Pik3cg, Prkaa1 (Ampk), Pten, Snca, Sqstm1, Tgfb1, Tgm2, Tnf, Tnfsf10 (Trail), Trp53 (p53)
Co-Regulators of Autophagy & the Cell Cycle
Bax, Cdkn1b (p27Kip1), Cdkn2a (p16INK4a), Ifng, Pten, Rb1, Tgfb1, Trp53 (p53)
Autophagy Induction by Intracellular Pathogens
Eif2ak3, Ifng, Lamp1
Autophagy in Response to Other Intracellular Signals
Ctsd, Ctss, Dram2, Eif4g1, Esr1 (Erα), Gaa, Hgs, Mapk14 (p38alpha), Pik3c3 (Vps34), Pik3r4, Rps6kb1, Tmem74, Ulk2, Uvrag
Chaperone-Mediated Autophagy
Hsp90aa1, Hspa8