Target List
Toll-Like Receptor (TLR) Signaling
Toll-Like Receptors & Cofactors
CD14, CTSK, LY96, TLR1, TLR2, TLR4, TLR5, TLR6, TLR9
MYD88-Dependent
FADD, IRAK1, IRAK3, IRF5, IRF7, MYD88, TAB1, TIRAP, TLR1, TLR2, TLR4, TLR5, TLR6, TLR9, TOLLIP, TRAF6
TICAM1 (TRIF)-Dependent (MYD88-Independent) Signaling
IRF5, IRF7, RIPK1, TAB1, TICAM1, TLR4, TRAF6
Other Toll-Like Receptor Signaling Genes
AKT1, CASP8, LBP, PIK3CA (p110-alpha), PIK3R1, RAC1
NOD-Like Receptor (NLR) Signaling
NOD-Like Receptors
NLRP1, NLRP3, NOD1, NOD2
Inflammasomes
CASP4, NLRP1, NLRP3, PYCARD
Regulation of NOD-like Receptor (NLR) Signaling
BIRC3, CARD9, CASP8, HSP90AA1, MEFV, PSTPIP1, RIPK2, SUGT1, TNF, XIAP
Other Bacterial Pattern Recognition Receptors (PRRs)
APCS, CRP, DMBT1, ZBP1
Signaling Downstream of Antibacterial Responses
NFκB Signaling
BCL10, CHUK, IKBKB (IKKβ), MALT1, NFKB1, NFKBIA, RELA, TNFRSF1A
ERK1 / ERK2 Signaling
JUN, MAP2K1 (MEK1), MAPK1, MAPK3, MAP3K8
JNK / p38 Signaling
JUN, MAP2K3 (MEK3), MAP2K4, MAPK14 (p38ALPHA), MAPK8
Apoptosis
AKT1, BIRC3, CASP4, CARD9, CASP8, CD14, FADD, GCH1, IFNB1, IKBKB (IKKβ), IL12A, IL12B, IL1B, IL6, IRAK1, JUN, MALT1, MAPK1, MAPK8, MPO, NFKB1, NFKBIA, PIK3CA (p110-alpha), PRDX2, PYCARD, RAC1, RIPK1, RIPK2, TNF, TNFRSF1A, TRAF6
Inflammatory Response
AKT1, APCS, CCL3 (MIP-1A), CCL5 (RANTES), CD14, CRP, CYBB, IL1B, IL6, CXCL8, LBP, LY96, LYZ, MEFV, MYD88, NFKB1, NLRP3, NOD1, RAC1, RELA, RIPK2, SLC11A1, TIRAP, TLR1, TLR2, TLR4, TLR5, TLR6, TLR9, TNF, TNFRSF1A, TOLLIP
Cytokines & Chemokines
CCL3 (MIP-1A), CCL5 (RANTES), IFNB1, IL12A, IL12B, IL18, IL1B, IL6, CXCL8
Antimicrobial Peptides
BPI, CAMP, CTSG, LCN2, LTF, LYZ, MPO, SLPI