Target List
NFÎşB Signaling
NFκB Signaling Ligands & Receptors​
CARD10, CD40 (TNFRSF5), EGFR, F2R, FASLG (TNFSF6), IL10, IL1B, IL1R1, CXCL8, NOD1 (CARD4), TLR1A, TLR2A, TLR3, TLR4, TNFRSF1A, TNFRSF1B, TNFRSF10B, TNFSF10 (TRAIL)
Signaling Downstream of NFκB​
BIRC2 (c-IAP-2), FADD, IRAK2, IRF1, MYD88, RIPK1, RIPK2, TBK1, TICAM1 (TRIF), TNFAIP3, TOLLIP, TRADD, TRAF2, TRAF3, TRAF5, TRAF6
Cytoplasmic Sequestering / Releasing of NFκB​
CHUK (IKKα), IKBKB, IKBKE, NFKBIA (IκBα, MAD3), NFKBIB, NFKBIE
Transcription Factors​
ATF2, CREBBP, NFKB1, NFKB2, REL, RELA, RELB, SMAD3
NFÎşB Responsive Genes
Immune Response​
CCL20 (MIP-3A), CCL5 (RANTES), CD83, CSF1 (MCSF), CSF2 (GM-CSF), CSF3 (GCSF), CXCL8, IFNA3, IFNG
Apoptosis​
AGT, BCL2A1, BCL2L1 (BCLXL), LITAF (TNF), PCASP1
Other Factors Involved in NFÎşB Pathway
Kinases​
AKT1, EIF2AK2, MAPK1 (ERK2), MAP3K1, RAF1, ZAP70
Transcription Factors​
ATF1, EGR1, FOS, JUN, STAT1
Other NFκB Signaling Genes​
BCL10, CARD11, CASP1 (ICE), CASP8 (FLICE), CFLAR, HMOX1, LITAF (TNF), PSIP1, RHOA, SLC20A1, STX11, TIFA, TNFAIP2