Target List
JAK & STAT Proteins
Janus Kinase Activity
JAK1, JAK2, JAK3, TYK2
STAT Family Members
STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6
JAK / STAT Signaling Regulators
PIAS1, PIAS2, PIAS3, PRL, PTPN1 (PTP1B), PTPRC, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5
Receptors Binding & Activating JAK Proteins
CSF1R, EGFR (ERBB1), EPOR, F2R (PAR1), GHR, IFNAR1, IFNGR1, IL10RA, IL2RA (CD25), IL2RG, IL4R (CD124), IL6ST (GP130), INSR, MPL, PDGFRA
SH3 / SH2 Adaptor Protein Activity
CRK, GRB2, SH2B1, SRC, STAM
STAT-Interacting Transcription Factors & Regulators
Transcription Factors
CEBPB, GATA3, IRF1, IRF9, JUN, JUNB, NFKB1, NR3C1 (GRL), SMAD1 (MADH1), SMAD2 (MADH2), SMAD3 (MADH3), SMAD4 (MADH4), SMAD5 (MADH5), SP1, SPI1, USF1
Transcriptional Regulation
PIAS1, PIAS3, YY1
STAT-Induced
STAT1-Induced
CXCL9 (MIG), IRF1, JUNB, NOS2 (iNOS)
STAT3-Induced
A2M, BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), CCND1, CDKN1A (p21CIP1, WAF1), CEBPD, CRP, FAS, IRF1, LRG1, MCL1, MYC, SOCS1, SOCS3
STAT4-Induced
FCGR1A, IFNG, IRF1, MYC
STAT5-Induced
BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), CCND1, CDKN1A (p21CIP1, WAF1), IL2RA (CD25), IRF1, OSM
STAT6-Induced
FCER2, GATA3, IL4, IL4R (CD124)
STAT1 / STAT2 / p48 Induced
ISG15, OAS1
Apoptosis
AKT1, BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), CDKN1A (p21CIP1, WAF1), F2 (Thrombin), F2R (PAR1), FAS, IL2RA (CD25), MCL1, NFKB1, PRLR, STAT1
Cell Growth and / or Maintenance
Cell Cycle
CCND1, CDKN1A (p21CIP1, WAF1), EGFR (ERBB1), F2 (Thrombin), F2R (PAR1), IL2RA (CD25), IRF1, JAK2, MYC, STAT1
Cell Growth
A2M, EGFR (ERBB1), GHR, IFNG, IL4, INSR, OSM, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5
Cell Proliferation
CSF1R, IL2RG, IL4, MPL, OSM, PDGFRA, SMAD3 (MADH3)
Cell Differentiation
IL20, IL4, NOS2 (iNOS), SOCS2, SOCS5
Immune Response
Acute-Phase Response
CEBPB, CRP, F2 (Thrombin), STAT3
Humoral Immune Response
FCER2, CSF1R, IL4, NFKB1, YY1
Inflammatory Response
CEBPB, CRP, CXCL9 (MIG), IL20, NFKB1, NOS2 (iNOS), NR3C1 (GRL)
Other Immune Response Genes
CXCL9 (MIG), FAS, FCGR1A, ISG15, IFNG, IL2RA (CD25), IL2RG, IL4R (CD124), IL6ST (GP130), IRF1, IRF9, OAS1, OSM, PRLR, PTPN11, STUB1