Target List
Skeletal Muscle Contractility
Dystrophin-Glycoprotein Complex​
CAMK2G, CAPN3, CAV3, DAG1, DMD, DYSF, LMNA, MAPK1 (ERK2), SGCA
Titin Complex​
ACTA1, ACTN3, CAPN3, CRYAB, DES, LMNA, MAPK1 (ERK2), MSTN, MYH1, MYH2, MYOT, NEB, SGCA, TNNI2, TNNT1, TNNT3, TRIM63 (MURF1), TTN
Energy Metabolism​
CS, HK2, PDK4, SLC2A4 (GLUT4)
Fast-Twitch Fibers​
ATP2A1, MYH1, MYH2, TNNI2, TNNT3
Slow-Twitch Fibers​
MB, MYH1, TNNC1, TNNT1
Other Skeletal Muscle Contractility Genes​
DMPK, IKBKB (IKKβ), RPS6KB1
Skeletal Myogenesis
ACTA1, ADRB2, AGRN, BCL2, BMP4, CAPN2, CAST, CAV1, CTNNB1, DMD, HDAC5, IGF1, IGFBP3, IGFBP5, MEF2C, MSTN, MUSK, MYF5, MYF6, MYOD1, MYOG, PAX3, PAX7, PPP3CA, RHOA, RPS6KB1, UTRN
Skeletal Muscle Hypertrophy
ACTA1, ACVR2B, ADRB2, IGF1, IGFBP5, MSTN, MYF6, MYOD1, RPS6KB1
Skeletal Muscle Autocrine Signaling
ADIPOQ (ACRP30), FGF2 (BFGF), IGF1, IGF2, IL6, LEP (Leptin), MSTN, TGFB1
Diabetes / Metabolic Syndrome
ADIPOQ (ACRP30), LEP (Leptin), PPARG, PPARGC1A (PGC-1α), PPARGC1B (PGC-1β), PRKAA1 (AMPK), PRKAB2, PRKAG1, PRKAG3, SLC2A4 (GLUT4)
Skeletal Muscle Wasting / Atrophy
Autophagy​
CAPN2, CASP3, FBXO32, FOXO1, FOXO3, MSTN, NOS2 (iNOS), PPARGC1A (PGC-1α), PPARGC1B (PGC-1β), RPS6KB1, TRIM63 (MURF1)
Dystrophy​
AKT1, AKT2, FBXO32, IL1B, MAPK1 (ERK2), MAPK14 (p38ALPHA), MAPK3 (ERK1), MAPK8 (JNK1), MMP9, NFKB1, TNF, TRIM63 (MURF1), UTRN