Target List
IL6 / STAT3 Signaling
STAT3 Activators​
EGFR (ERBB1), IL10, IL11, IL17A, IL21, IL23A, IL6
Cell Surface Receptors​
CD4, CD40 (TNFRSF5), CSF3R (GM-CSFR), FAS, IL18R1, IL1R1, IL2RA (CD25), IL6R, IL6ST (GP130), LIFR, TNFRSF10B (DR5), TNFRSF1A (TNFR1), TNFRSF1B
Signaling Upstream of IL6 / STAT3​
AKT1, JAK2, JAK3, MAP2K1, MAPK1 (ERK2), MAPK14 (p38ALPHA), MAPK3 (ERK1), MAPK8 (JNK1), MTOR, MYC, PIAS3, SOCS1, SOCS3, SRC, TYK2
Signaling Downstream of IL6 / STAT3​
BAX, BCL2, CDKN1A (p21CIP1, WAF1), HGF, MET, PIM1, STAT3
IL6 / STAT3 Signaling Target Genes​
CCL2 (MCP-1), CCL5 (RANTES), CEBPD, CXCL10 (INP10), IL10, IL11, IL17A, IL1B, IL21, IL6, CXCL8 (IL8), MYC, SOCS3
Cytokines
CCL2 (MCP-1), CCL3 (MIP-1A), CCL4 (MIP-1B), CCL5 (RANTES), CD40LG, CSF1 (MCSF), CSF2 (GM-CSF), CSF3 (GCSF), CXCL10 (INP10), FASLG (TNFSF6), IL10, IL11, IL13, IL15, IL17A, IL18, IL1A, IL1B, IL2, IL21, IL22, IL23A, IL3, IL4, IL5, IL6, CXCL8 (IL8), LIF, LTA (TNFB), OSM, TNF, TNFSF10 (TRAIL)
NFÎşB Signaling
NFKB1, NFKBIA (IκBα, MAD3), RELA, TLR4
Pathway Activity Signature Genes
BCL3, CASP4, CEBPD, GLRX, IFITM2, IL6ST (GP130), JUNB, NRP1, PHF21A, PROS1, NECTIN2, SOCS3, STAT3, TGM2, TNFRSF1A (TNFR1), TUBB2A