Target List
Acute Rejection - Innate Immunity
Pattern Recognition Receptors (PRRs)​
TLR3, TLR4, TLR9
Cytokines​
CCL2 (MCP-1), CCL4 (MIP-1B), CCL5 (RANTES), CCL11 (Eotaxin), CSF2 (GM-CSF), CXCL10 (INP10), IFNG, IL10, IL12A, IL13, IL16, IL1B, IL2, IL2RA (CD25), IL3, IL32, IL4, IL5, IL6, CXCL8 (IL8), TNF
Other Innate Immunity Genes​
ADAM17 (CD156B), C3, CASP1 (ICE), CASP3, CASP8 (FLICE), CCR2, CCR3, CD14, CD28, CD8A, FAS, FASLG (TNFSF6), FCGR1A, GZMA, GZMB, MS4A1, NFKB1, NOS2 (iNOS), PRF1, PSMB9, STAT1, STAT6, TAP1 (ABCB2), TNFAIP3, TNFSF10 (TRAIL)
Acute Rejection - Adaptive Immunity
Th1 Markers & Immune Response​
CCR5, CCR7, CD80, CTLA4, CXCR3, IFNG, STAT4
Th2 Markers & Immune Response​
CD86, IL10, IL13, IL4, IL5, IL6
T-Cell Activation​
CD80, CD86, ICAM1, IFNG
Cytokines​
CCL2 (MCP-1), CCL4 (MIP-1B), CCL5 (RANTES), CSF2 (GM-CSF), CXCL10 (INP10), IFNG, IL10, IL13, IL4, IL5, IL6, TNF
Leukocyte Recruitment​
CD40 (TNFRSF5), CD40LG, ICAM1, THBS1 (TSP-1), VCAM1
Chronic Rejection
Pro-Fibrotic​
CCL3 (MIP-1A), CCN2, IL4, IL5, IL13
Anti-Fibrotic​
BMP7, COL1A2, IFNG, IL10, THBS2
Cell Adhesion Molecules​
ICAM1, ITGA2, ITGAE, ITGAM, VCAM1
Cellular Infiltration​
BMP7, CCR2, CD44, COL1A2, CX3CR1, CXCL9 (MIG), CXCL11 (I-TAC, IP-9), CXCR4, MMP1, MMP2, MMP7, MMP9, PECAM1, TGFB1, TGFB2, TGFB3, THBS2, TIMP1, VEGFA