Target List
Cystic Fibrosis Modifier Genes
ADIPOR2, ADRB2, EDNRA, GCLC, GSTM1 (MGST1), IFRD1, CXCL8 (IL8), MBL2, MSRA, NOS3 (eNOS), SCNN1B, SCNN1G, SERPINA1, TCF7L2, TGFB1, TNF, TNFRSF1A (TNFR1)
CTFR Interactors
AHSA1, CANX, CFTR, DNAJA1, DNAJC5, EZR, GOPC, HSP90AA1, HSPA4 (HSP70), HSPA8, NME1 (NM23), PDZK1, PTPA, PRKAA1 (AMPK), PRKAA2, SLC26A3, SLC9A3R1, SLC9A3R2, SNAP23, STX1A, STX8, TGFB1, TJP1, VCP
Neutrophil Chemotaxis
CCL2 (MCP-1), CXCR2, EDN1, EDNRA, IL1B, CXCL8 (IL8), ITGB2
Inflammatory Response
ACE, ADRB2, ALOX12B, CCL2 (MCP-1), CXCL1 (GRO1, GROa, SCYB1), CXCL2 (GRO2, GROb, SCYB2), DEFB1, EDNRA, IL10, IL1B, IL6, CXCL8 (IL8), ITGB2, MBL2, NFKB1, PLA2G5, PTGS2 (COX2), S100A8, SERPINA1, TGFB1, TLR2, TLR4, TLR5, TNF, TNFRSF11A (RANK), TNFRSF1A (TNFR1)
Immune Response
Innate Immunity
CCL2 (MCP-1), CLU, DEFB1, ICAM1, LCN2 (NGAL), MAPK1 (ERK2), MBL2, NFKB1, NFKBIA (IκBα, MAD3), PRKCE, TGFB1, TLR2, TLR4, TLR5, TNFSF10 (TRAIL)
Adaptive Immunity
CLU, FAS, ICAM1, IL10, IL1B, IL7R, MBL2, TGFB1, TLR4, TNF, TNFRSF11A (RANK)
Unfolded Protein Response
CALR, DNAJA1, HSP90AA1, HSPA1A (HSP70-1A), HSPA4 (HSP70), HSPA8, HSPH1 (HSP105), VCP
Ion Binding & Transport
ADK, KCNE1, NR4A2 (NURR1), SCNN1B, SCNN1G, SLC9A3R1
Oxidative Stress
CLU, DUSP1 (PTPN16), GCLC, IL6, LCN2 (NGAL), MBL2, MSRA, NOS3 (eNOS), PTGS2 (COX2), SFTPB
Other Cystic Fibrosis Genes
EPSTI1, IGFBP5, ITGA2, KIT (CD117), MET, PRTN3, SLPI