Target List
Protease Activated Receptors (PARs)
F2r (Par1), F2rl1 (Par2), F2rl2 (Par3), F2rl3 (Par4)
Proteases Activating Protease Activated Receptors
Ctsg, F10, F2 (Thrombin), F3, F7, Mmp1a, Plg, Proc
Thrombin Signaling
Thrombin & Receptors
F2 (Thrombin), F2r (Par1), F2rl1 (Par2), F2rl2 (Par3), F2rl3 (Par4)
Signaling Downstream of Thrombin
Adcy7, Akt1, Gnai1, Hras, Ikbkb (IKKbeta), Map2k1 (Mek1), Mapk14 (p38alpha), Prkca, Prkce, Ptk2 (Fak), Rhoa, Rhoh, Rps6kb1, Src
Transcription Factors
Egr1, Elk1, Gata2, Nfkb1, Rel, Rela
Cell Adhesion Molecules
Icam1, Itgam, Itgav, Itgb1, Kitl (Scf), Rhoa, Rhoh, S1pr1, Sele, Selp, Src, Thbs1 (TSP-1), Vcam1
Coagulation
F10, F2 (Thrombin), F2r (Par1), F2rl1 (Par2), F2rl2 (Par3), F2rl3 (Par4), F3, F7, Hspa5 (Grp78), Mmp1a, Plau (uPA), Plaur (uPAR), Plek, Plg, Proc, Procr (Epcr), Selp, Serpinb2 (Pai-2), Serpine1 (Pai-1), Tfpi, Thbd, Thbs1 (TSP-1)
PAR-Regulated Genes
Activated Protein C Signaling
Cd55, Dkk1, Ets1, F3, Hbegf, Il6, Itgav, Junb, Nfatc1, Plaur (uPAR), Ptgs2 (Cox2), Ptpn11, Rela, Serpinb2 (Pai-2), Thbs1 (TSP-1), Trp53 (p53), Vegfa
Thrombin Signaling
Ccl12 (MCP-5, Scya12), Cd55, Dkk1, Ets1, F3, Hbegf, Hmgcr, Il1b, Il6, Junb, Kdr (Vegfr2), Kitl (Scf), Mif, Nab2, Nfatc1, Plaur (uPAR), Ptgs2 (Cox2), Ptpn11, Serpinb2 (Pai-2), S1pr3, Thbs1 (TSP-1), Tnf, Vegfa
Factor VIIa / PAR1/2 Signaling
Cdkn1a (p21Cip1, Waf1), Csf2 (GMCSF), Ccn2, Nfkb1, Plau (uPA), Serpine1 (Pai-1)
Factor VIIa / PAR2 Signaling
Csf1 (Mcsf), Csf2 (GMCSF), Cxcl3, Ccn1, Itgb1, Vegfc
TLR4 / PAR2 Signaling
Il10, Il13, Il4, Il6, Tnf
Other PAR-Regulated Genes
Gja1 (Cx43), Mmp2, Sele, Selp, Serpinb5 (Maspin), Tgfb1, Vcam1