Target List
Skeletal Development
Cartilage Condensation
BMPR1B, COL2A1, BMP1, MGP, SOX9
Ossification
AHSG, BMP2, BMP4, BMP5, LOC100008826, BMPR1A, BMPR1B, BMPR2, CDH11, CHRD, COL2A1, CTSK, DLX5, FGF2 (BFGF), FGFR2, GLI1, IGF1, IGF2, EGFR (ERBB1), IHH, IGF1R, CSF1 (CSF1, MCSF), CSF1 (MCSF), RUNX2 (RUNX2), BGLAP, TNFSF11, IBSP, COL1A1, BMP3, ACVR1, BMP1, SP7, NOG, MGP, MMP2, MMP9, SHH, SMAD1, SOX9, SPP1, TGFB1, TGFB2, TGFB3
Osteoclast Differentiation
CSF1 (CSF1, MCSF), CSF1 (MCSF), BGLAP, TNFSF11, TNF
Osteoblast Differentiation
BMP2, BMP4, LOC100008826, BMPR1A, BMPR1B, BMPR2, CHRD, DLX5, FGF2 (BFGF), FGFR2, GLI1, IGF1, IHH, RUNX2 (RUNX2), BGLAP, SOX2, COL1A1, IGFBP5, PTH, ACVR1, SP7, NOG, NF1, PTHLH, SMAD1, SPP1
Other Skeletal Development Genes
CTNNB1, FGFR1, IL6, ALPL, TGFBR2, TGFBR1
Bone Mineral Metabolism
Bone Mineralization
AHSG, BMP2, BMP4, LOC100008826, BMPR1A, BMPR1B, BMPR2, FGFR2, IGF1, BGLAP, PTH, ACVR1, MGP, MMP13, PTGS2 (COX2), PTHLH, SOX9, TGFB1, TGFB3
Calcium Ion Binding & Homeostasis
CALCR, CDH11, FGF2 (BFGF), ITGB1, EGF, VDR, BGLAP, ANXA5, MMP2, TGFB1
Extracellular Matrix (ECM) Molecules
Collagens
COL10A1, COL14A1, COL15A1, COL1A2, COL2A1, COL5A1, COL3A1, COL1A1
Extracellular Matrix (ECM) Protease Inhibitors
AHSG, SERPINH1
Extracellular Matrix (ECM) Proteases
CTSK, MMP2, MMP9, MMP13
Other Extracellular Matrix (ECM) Molecules
BGN, FLT1 (VEGFR1), ALPL
Cell Adhesion Molecules
Cell-Cell Adhesion
BMPR1B, CDH11, COL14A1, COL2A1, ITGB1, EGFR (ERBB1), IHH, TNFSF11, BMP1, SOX9, TGFB1, TNF, VCAM1
Cell-Extracellular Matrix (ECM) Adhesion
CD36, ITGA1, ITGAM, ITGB1, COL3A1, ITGA2, CSF1 (MCSF), CSF1 (CSF1, MCSF)
Other Cell Adhesion Molecules
COL15A1, COL5A1, FN1, BGLAP, TNF
Growth Factors
CSF2, FGF1, FGF2 (BFGF), IGF1, IGF2, EGF, PDGFA, CSF3 (GCSF), VEGFA
Transcription Factors
GLI1, RUNX2 (RUNX2), NFKBIL1, SOX2, SMAD5, SMAD1, SMAD2, SOX9