Target List
Pro-Fibrotic
CCL2 (MCP-1), CTGF, IL4, GREM1, IL21, IL13RA2, CCL3, IL5, IL13
Anti-Fibrotic
LOC100008826, HGF, IFNG, IL10, IL13RA2
Extracellular Matrix (ECM) & Cell Adhesion Molecules
Extracellular Matrix (ECM) Structural Constituents​
COL1A2
Extracellular Matrix (ECM) Remodeling Enzymes​
TIMP1, LOX, MMP1, MMP13, MMP14, MMP2, MMP3, MMP9, PLAT (TPA), PLAU (UPA), PLG, SERPINB2, SERPINE1 (PAI-1), SERPINH1, TIMP2, TIMP3, TIMP4
Cell Adhesion Molecules​
ITGA1, ITGAV, ITGB1, ITGB5, ITGB6, ITGB8, ITGA2
Inflammatory Cytokines & Chemokines
CCL2 (MCP-1), CCL4 (MIP-1B), CXCR4, IFNG, IL10, IL1A, IL1B, IL4, IL4R, CCR7, IL21, IL13RA2, CCL3, IL12A, ILK, IL5, CCR2, IL13, TNF
Growth Factors
CTGF, EDN1, HGF, EGF, PDGFC, PDGFA, PDGFD, VEGFA
Signal Transduction
TGFβ Superfamily Members​
LOC100008826, CAV1, DCN, ENG (EVI-1), SMAD7, SAR1B, GREM1, LTBP1, SAR1A, CUL1, TGFBR1, INHBC, PRKCD, SMAD2, SMURF2, TGFB1, TGFB2, TGFB3, THBS1 (TSP-1), ZFYVE9
Transcription Factors​
CEBPZ, JUN, ETS1, FLI1, NFIB, SP3, MYC, SP1, STAT1, STAT6, YBX1
Epithelial-to-Mesenchymal Transition (EMT)
LOC100008826, COL1A2, ITGAV, ITGB1, ILK, MMP2, MMP3, MMP9, SERPINE1 (PAI-1), SKIL, SMAD2, TGFB1, TGFB2, TGFB3