Target List
Induction of Apoptosis
Death Domain Receptors
CRADDLOC708606 (FADD)TNFRSF10B (TNFRSF10B, DR5)TNFRSF10B (TNFRSF10B)TNF
DNA Damage & Repair
CIDEALOC695164 (TP73)ABL1TP53 (p53)
Extracellular Apoptotic Signals
CFLAR (CASPER)DAPK1PRKCATNFRSF25 (DR3)
Other Pro-Apoptotic Genes
BAK1BCL2L11BNIP1BNIP3LCASP1 (ICE)CASP10 (MCH4)CASP14CASP2CASP3CASP4CASP8 (FLICE)CD27CD70DFFAFAS (TNFRSF6)GADD45ALOC100426120 (BNIP3)FASLG (TNFSF6)LOC698160 (TRADD)LOC698788 (CASP6)PYCARD (TMS1, ASC)BCL10BADBAXLTA (TNFB)MAPK1 (ERK2)NOD1TNFRSF10A (TRAIL-R)TNFRSF9TNFSF10 (TRAIL)TNFSF8TP53BP2TRAF3
Anti-Apoptotic
AKT1BAG1BAG3BAG4BCL2A1 (Bfl-1, A1)BCL2L10BDNFBIRC3 (c-IAP1)BIRC5BIRC6BNIP1BNIP2BNIP3LCD27CD40LG (TNFSF5)CFLAR (CASPER)DAPK1FAS (TNFRSF6)IGF1RIL10IL2LOC100426120 (BNIP3)LOC693554 (BRAF)BCL2 (BCL2)BCL2L1 (BCL-X)BFARBAXCDKN1A (p21CIP1, WAF1)MCL1NAIPNOL3 (CARD6)RIPK2TNFXIAP
Regulation of Apoptosis
Negative Regulation of Apoptosis
BAG1BAG3BAG4BCL2A1 (Bfl-1, A1)BCL2L10BIRC2 (c-IAP1)BIRC3 (c-IAP1)BIRC6BNIP1BNIP2BNIP3LCASP3CD27CD40LG (TNFSF5)CFLAR (CASPER)CIDEADAPK1DFFAFAS (TNFRSF6)IGF1RLOC100426120 (BNIP3)LOC693554 (BRAF)LOC695164 (TP73)BCL2 (BCL2)BCL2L1 (BCL-X)BFARBCL10MCL1NAIPNOL3 (CARD6)TP53 (p53)XIAP
Positive Regulation of Apoptosis
AKT1BAK1BCL2L11BNIP3LCASP1 (ICE)CASP10 (MCH4)CASP14CASP2CASP4CASP8 (FLICE)CD40 (TNFRSF5)CD70CRADDLOC100426120 (BNIP3)FASLG (TNFSF6)LOC698160 (TRADD)LOC698788 (CASP6)LOC708606 (FADD)PYCARD (TMS1, ASC)TRAF4TNFRSF10B (TNFRSF10B, DR5)TNFRSF10B (TNFRSF10B)BADBAXABL1LTA (TNFB)LTBRNOD1RIPK2TNFTNFRSF10A (TRAIL-R)TNFRSF25 (DR3)TNFRSF9TNFSF10 (TRAIL)TNFSF8TP53 (p53)TP53BP2TRAF3TRAF5
Death Domain Receptors
CRADDDAPK1LOC698160 (TRADD)LOC708606 (FADD)TNFRSF10B (TNFRSF10B, DR5)TNFRSF10B (TNFRSF10B)TNFRSF10A (TRAIL-R)TNFRSF11B (OPG)TNFRSF1A (TNFR1)TNFRSF21TNFRSF25 (DR3)
Caspases & Regulators
Caspases
CASP1 (ICE)CASP10 (MCH4)CASP14CASP2CASP3CASP4CASP5CASP7CASP8 (FLICE)CASP9CFLAR (CASPER)CRADDLOC698788 (CASP6)PYCARD (TMS1, ASC)
Caspase Activation
APAF1BCL2L10CARD8CASP1 (ICE)CASP9PYCARD (TMS1, ASC)TNFRSF10B (TNFRSF10B, DR5)TNFRSF10B (TNFRSF10B)BAXMYCNOD1TNFRSF10A (TRAIL-R)TP53 (p53)
Caspase Inhibition
CD27XIAP