Target List
NFÎşB Pathway
Ligands & Receptors​
CD40 (TNFRSF5), CD40LG (TNFSF5), CD83, EGFR, FASLG (TNFSF6), IL10, IL1A, IL1B, IL1R1, CXCL8, TNFRSF10B (TNFRSF10B, DR5), TNFRSF10B (TNFRSF10B), LTBR, NOD1, TLR1, TLR2, TLR3, TLR4, TLR6, TLR9, TNF, TNFRSF1A (TNFR1), TNFRSF10A (TRAIL-R), TNFSF10 (TRAIL)
Signaling Downstream of NFκB​
BIRC2 (c-IAP1), IRAK1, IRAK2, IRF1, LOC708606 (FADD), LOC698160 (TRADD), MYD88, RIPK1, TBK1, TICAM1 (TRIF), TNFAIP3, TRAF2, TRAF3, TRAF6
Cytoplasmic Sequestering / Releasing of NFκB​
BCL3, CHUK (IKKα), IKBKB (IKKβ), IKBKG, NFKBIA (IκBα, MAD3), NFKBIE
Transcription Factors​
NFKB1, NFKB2, REL, RELA, RELB
NFÎşB Responsive Genes
Immune Response​
CCL2, CCL5 (RANTES), CSF1 (MCSF), CSF2, CSF3 (GCSF), ICAM1, IFNG, CXCL8, LOC694631 (IFNA1), LTA (TNFB), PLAU, TNF
Apoptosis​
AGT, BCL2A1 (Bfl-1, A1), BCL2L1 (BCL-X), BIRC3 (c-IAP1)
Other Factors Involved in NFÎşB Pathway
Kinases​
AKT1, MAP3K1 (MEKK1), RAF1
Transcription Factors​
ATF1, EGR1, FOS, LOC722713, JUN, STAT1
Other NFκB Signaling Genes​
CARD11, CASP1 (ICE), CASP8 (FLICE), CFLAR (CASPER), HMOX1, MALT1, PSIP1, RHOA (RHOA), TIMP1
Pathway Activity Signature Genes
BIRC3 (c-IAP1), CCL20 (MIP-3A), CD83, CXCL2, ICAM1, CXCL8, IRF1, NFKB1, NFKBIA (IκBα, MAD3), NFKBIE, STX11, TIFA, TNF, TNFAIP3