Target List
NFκB Pathway
Ligands & Receptors
CD40 (TNFRSF5)CD40LG (TNFSF5)CD83EGFRFASLG (TNFSF6)IL10IL1AIL1BIL1R1CXCL8TNFRSF10B (TNFRSF10B, DR5)TNFRSF10B (TNFRSF10B)LTBRNOD1TLR1TLR2TLR3TLR4TLR6TLR9TNFTNFRSF1A (TNFR1)TNFRSF10A (TRAIL-R)TNFSF10 (TRAIL)
Signaling Downstream of NFκB
BIRC2 (c-IAP1)IRAK1IRAK2IRF1LOC708606 (FADD)LOC698160 (TRADD)MYD88RIPK1TBK1TICAM1 (TRIF)TNFAIP3TRAF2TRAF3TRAF6
Cytoplasmic Sequestering / Releasing of NFκB
BCL3CHUK (IKKα)IKBKB (IKKβ)IKBKGNFKBIA (IκBα, MAD3)NFKBIE
Transcription Factors
NFKB1NFKB2RELRELARELB
NFκB Responsive Genes
Immune Response
CCL2CCL5 (RANTES)CSF1 (MCSF)CSF2CSF3 (GCSF)ICAM1IFNGCXCL8LOC694631 (IFNA1)LTA (TNFB)PLAUTNF
Apoptosis
AGTBCL2A1 (Bfl-1, A1)BCL2L1 (BCL-X)BIRC3 (c-IAP1)
Other Factors Involved in NFκB Pathway
Kinases
AKT1MAP3K1 (MEKK1)RAF1
Transcription Factors
ATF1EGR1FOSLOC722713JUNSTAT1
Other NFκB Signaling Genes
CARD11CASP1 (ICE)CASP8 (FLICE)CFLAR (CASPER)HMOX1MALT1PSIP1RHOA (RHOA)TIMP1
Pathway Activity Signature Genes
BIRC3 (c-IAP1)CCL20 (MIP-3A)CD83CXCL2ICAM1CXCL8IRF1NFKB1NFKBIA (IκBα, MAD3)NFKBIESTX11TIFATNFTNFAIP3