Target List
Insulin Receptor-Associated Proteins
Insulin & Receptors
FLOT1, IRS1, IRS2, IRS4, SORBS2
Insulin-Like Growth Factors & Receptors
GRB10, IGF1R, IGFBP1
SH3 / SH2 Adaptor Proteins
CBL, GAB1, GRB10, IRS4, GRB2 (GRB2), NCK1
Other Insulin Receptor-Associated Proteins
CAP1, DOK1, FRS3, INSR, PPP1CA, PPP1R3A (GM), PTPN1, PTPRF, SHC1
PI3 Kinase Signaling
PI3 Kinase Canoncial Pathway Genes
AKT1, AKT2, AKT3, EIF2B1, EIF4EBP1, GSK3A, GSK3B, PRKCZ (PRKCZ), PIK3CA, PIK3CB, PIK3R1, PIK3R2, PRKCG, PRKCI
PI3 Kinase Signaling Target Genes
ADRA1D, BCL2L1 (BCL-X), DUSP14, G6PC, HK2, IGFBP1, PCK2, SERPINE1 (PAI-1), SLC2A4 (GLUT4), SREBF1, UCP1, VEGFA
MAP Kinase Signaling
MAP Kinase Canoncial Pathway Genes
ARAF, EIF2B1, HRAS, GRB2 (GRB2), LOC716899 (RPS6KA2), MAP2K1, MAPK1 (ERK2), RAF1, RRAS, RRAS2, SHC1, SOS1
MAP Kinase Signaling Target Genes
BCL2L1 (BCL-X), ERCC1, FOS, KLF10, LDLR, NOS2 (iNOS), RNASE4, UCP1
Primary Insulin Signaling Target Genes
FOS, GCG, JUN, LEP, CEBPB (CEBPB), LOC717153 (CEBPA), PRL
Secondary Insulin Signaling Effector Target Genes
NPY, PCK2, SLC2A1, SLC2A4 (GLUT4), TG
PPARγ Targets
ACOX1, ADRB3, CAP1, CEBPB (CEBPB), LOC717153 (CEBPA), LOC721138 (CFD), LOC722620 (SLC27A4), PCK2, PPARG, RETN
SREBP1 Targets
ACACA, FBP1, G6PC, GCK, PCK2, PKLR, PKM
Carbohydrate Metabolism
Glucose Metabolism
EXOC7, FBP1, FLOT1, G6PC, GCK, HK2, IRS2, PCK2, PKLR, PKM, SLC2A1, SLC2A4 (GLUT4), SORBS2
Glycogen Metabolism
G6PC, GSK3B, PPP1CA, PPP1R3A (GM)
Other Carbohydrate Metabolism Genes
ADRB3, GPD1, INSR
Lipid Metabolism
Cholesterol Metabolism
LDLR, SREBF1
Fatty Acid Metabolism
ACOX1, ACACA, LOC722620 (SLC27A4)
Lipid Transport
LDLR, LOC722620 (SLC27A4), SORBS2
Other Lipid Metabolism Genes
ARAF, LEP, PRKCZ (PRKCZ), PPARG, PRKCG, PRKCI, RAF1, SHC1
Protein Metabolism
Protein Phosphatases
DUSP14, PPP1CA, PTPN1, PTPRF
Protein Kinases
AKT1, AKT2, AKT3, ARAF, GSK3A, GSK3B, IGF1R, INSR, PRKCZ (PRKCZ), LOC716899 (RPS6KA2), MAP2K1, MAPK1 (ERK2), PRKCG, PRKCI, RAF1
Protein Biosynthesis
EIF2B1, EIF4EBP1, LDLR, PPP1CA, RNASE4
Protein Transport
PRKCI, RRAS2
Other Protein Metabolism Genes
CBL, DOK1, GAB1, GRB10, IRS1, NOS2 (iNOS), SORBS2, VEGFA
Transcription Factors & Regulators
Transcriptional Regulation
FOS, JUN, KLF10, CEBPB (CEBPB), LOC717153 (CEBPA), PPARG, SREBF1
Transcription Factors
CBL, JUN, CEBPB (CEBPB), LOC717153 (CEBPA), PPARG, SREBF1
Cell Growth & Differentiation
Cell Cycle
HK2, HRAS, IGF1R, KRAS, MAPK1 (ERK2), VEGFA
Cell Proliferation
GAB1, IGF1R, IRS2, NCK1, NPY, PRL, RAF1, SHC1, VEGFA
Growth Factors & Receptors
GAB1, IGF1R, IGFBP1, INSR, GRB2 (GRB2), SHC1, VEGFA
Cell Differentiation
NOS2 (iNOS), PPARG