Target List
Insulin Receptor-Associated Proteins
Insulin & Receptors
FLOT1IRS1IRS2IRS4SORBS2
Insulin-Like Growth Factors & Receptors
GRB10IGF1RIGFBP1
SH3 / SH2 Adaptor Proteins
CBLGAB1GRB10IRS4GRB2 (GRB2)NCK1
Other Insulin Receptor-Associated Proteins
CAP1DOK1FRS3INSRPPP1CAPPP1R3A (GM)PTPN1PTPRFSHC1
PI3 Kinase Signaling
PI3 Kinase Canoncial Pathway Genes
AKT1AKT2AKT3EIF2B1EIF4EBP1GSK3AGSK3BPRKCZ (PRKCZ)PIK3CAPIK3CBPIK3R1PIK3R2PRKCGPRKCI
PI3 Kinase Signaling Target Genes
ADRA1DBCL2L1 (BCL-X)DUSP14G6PCHK2IGFBP1PCK2SERPINE1 (PAI-1)SLC2A4 (GLUT4)SREBF1UCP1VEGFA
MAP Kinase Signaling
MAP Kinase Canoncial Pathway Genes
ARAFEIF2B1HRASGRB2 (GRB2)LOC716899 (RPS6KA2)MAP2K1MAPK1 (ERK2)RAF1RRASRRAS2SHC1SOS1
MAP Kinase Signaling Target Genes
BCL2L1 (BCL-X)ERCC1FOSKLF10LDLRNOS2 (iNOS)RNASE4UCP1
Primary Insulin Signaling Target Genes
FOSGCGJUNLEPCEBPB (CEBPB)LOC717153 (CEBPA)PRL
Secondary Insulin Signaling Effector Target Genes
NPYPCK2SLC2A1SLC2A4 (GLUT4)TG
PPARγ Targets
ACOX1ADRB3CAP1CEBPB (CEBPB)LOC717153 (CEBPA)LOC721138 (CFD)LOC722620 (SLC27A4)PCK2PPARGRETN
SREBP1 Targets
ACACAFBP1G6PCGCKPCK2PKLRPKM
Carbohydrate Metabolism
Glucose Metabolism
EXOC7FBP1FLOT1G6PCGCKHK2IRS2PCK2PKLRPKMSLC2A1SLC2A4 (GLUT4)SORBS2
Glycogen Metabolism
G6PCGSK3BPPP1CAPPP1R3A (GM)
Other Carbohydrate Metabolism Genes
ADRB3GPD1INSR
Lipid Metabolism
Cholesterol Metabolism
LDLRSREBF1
Fatty Acid Metabolism
ACOX1ACACALOC722620 (SLC27A4)
Lipid Transport
LDLRLOC722620 (SLC27A4)SORBS2
Other Lipid Metabolism Genes
ARAFLEPPRKCZ (PRKCZ)PPARGPRKCGPRKCIRAF1SHC1
Protein Metabolism
Protein Phosphatases
DUSP14PPP1CAPTPN1PTPRF
Protein Kinases
AKT1AKT2AKT3ARAFGSK3AGSK3BIGF1RINSRPRKCZ (PRKCZ)LOC716899 (RPS6KA2)MAP2K1MAPK1 (ERK2)PRKCGPRKCIRAF1
Protein Biosynthesis
EIF2B1EIF4EBP1LDLRPPP1CARNASE4
Protein Transport
PRKCIRRAS2
Other Protein Metabolism Genes
CBLDOK1GAB1GRB10IRS1NOS2 (iNOS)SORBS2VEGFA
Transcription Factors & Regulators
Transcriptional Regulation
FOSJUNKLF10CEBPB (CEBPB)LOC717153 (CEBPA)PPARGSREBF1
Transcription Factors
CBLJUNCEBPB (CEBPB)LOC717153 (CEBPA)PPARGSREBF1
Cell Growth & Differentiation
Cell Cycle
HK2HRASIGF1RKRASMAPK1 (ERK2)VEGFA
Cell Proliferation
GAB1IGF1RIRS2NCK1NPYPRLRAF1SHC1VEGFA
Growth Factors & Receptors
GAB1IGF1RIGFBP1INSRGRB2 (GRB2)SHC1VEGFA
Cell Differentiation
NOS2 (iNOS)PPARG