Target List
Autophagy Machinery Components
Autophagic Vacuole Formation​
AMBRA1, ATG16L1, ATG4A, ATG4C, ATG4D, ATG5, ATG9A, ATG9B, BECN1, CTSD, GABARAP, GABARAPL2, LAMP1, MAP1LC3B, ATG12 (ATG12), MAP1LC3A, ULK1 (ULK1), GABARAPL1, LOC717813 (ATG4B), LOC718945 (WIPI1), PSEN1, RB1CC1, RGS19, TM9SF1
Vacuole Targeting​
ATG4A, ATG4C, ATG4D, GABARAP, LOC717813 (ATG4B)
Protein Transport​
ATG16L1, ATG16L2, ATG3, ATG4A, ATG4C, ATG4D, ATG7, ATG9A, GABARAP, GABARAPL2, LOC711835 (ATG10), LOC717813 (ATG4B), RAB24
Autophagosome-Lysosome Linkage​
DRAM1, GABARAP, NPC1
Ubiquitination​
ATG7, ATG3, PARK7
Proteases​
ATG4A, ATG4C, ATG4D, LOC717813 (ATG4B)
Regulation of Autophagy
Co-Regulators of Autophagy & Apoptosis​
AKT1, APP, ATG5, BCL2L1 (BCL-X), BAD, BAK1, BAX, BECN1, CASP3, CASP8 (FLICE), CDKN1B, CLN3, CTSB, CXCR4, DAP, DAPK1, DRAM1, EIF2AK3, FAS (TNFRSF6), IFNG, IGF1, LOC100426120 (BNIP3), LOC694767 (HDAC1), ATG12 (ATG12), BCL2 (BCL2), LOC708606 (FADD), HDAC6, MAPK8 (JNK1), NFKB1, PIK3CG, PRKAA1 (AMPK), PTEN, SNCA, SQSTM1, TGFB1, TGM2, TNF, TNFSF10 (TRAIL), TP53 (p53)
Co-Regulators of Autophagy & the Cell Cycle​
BAX, CDKN1B, IFNG, MAPT, PTEN, RB1, TGFB1, TP53 (p53)
Autophagy Induction by Intracellular Pathogens​
EIF2AK3, IFNG, TLR9
Autophagy in Response to Other Intracellular Signals​
EIF4G1, ESR1 (ERα), GAA, HGS, CTSS (CTSS), LOC718976 (MAPK14, p38ALPHA), LOC718976 (MAPK14, p38ALPHA), PIK3CB, PIK3C3, PIK3R4, RPS6KB1, TMEM74, ULK2, UVRAG
Chaperone-Mediated Autophagy​
LOC695913 (HSP90AA1)