Target List
Up-Regulated in Neurotoxicity
Apoptosis
ABL1BAG4CASP7CDKN1A (p21CIP1, WAF1)CIDEACRADDDAPK1FAS (TNFRSF6)FASLG (TNFSF6)GCH1TNFRSF10B (TNFRSF10B, DR5)TNFRSF10B (TNFRSF10B)SOD2TNFRSF11B (OPG)TP53 (p53)TRAF4YWHAE
Neuron Development
CASP7DRP2EREGHEPHIL10MMP9PLP1SOD2TP53 (p53)YWHAE
Metabolism (Regulation & Mechanism)
ABL1ARG2ARRB1ATF4CDKN1A (p21CIP1, WAF1)CIDEADDIT3 (GADD153, CHOP)DYNLL1EREGGUCY1A3HSP90AA1IL10TNFRSF10B (TNFRSF10B)TNFRSF10B (TNFRSF10B, DR5)NFKB1POU1F1 (Pit-1)PYGBRASD1SLC16A3SOD2TP53 (p53)TRAF2USP7YWHAE
Nitric Oxide Response
ARG1ARG2DYNLL1GUCY1A3NOS1APNOSIPNOSTRINRASD1SLC16A3
Signal Transduction
ABL1ARRB1CD8BCDKN1A (p21CIP1, WAF1)CIDEADAPK1DDIT3 (GADD153, CHOP)FASLG (TNFSF6)GPR37GUCY1A3HSPA5 (GRP78)IL10TNFRSF10B (TNFRSF10B, DR5)TNFRSF10B (TNFRSF10B)RASD1TP53 (p53)TRAF2YWHAE
Ion Transporters
CAMK2DCLCN5CLCNKACLCNKBHEPHLOC719120 (TRPM4)SFXN5TRPM1
Other Genes Up-Regulated in Neurotoxicity
LOC711693 (ANGPTL4)PAPPAPDIA4
Down-Regulated in Neurotoxicity
Apoptosis
LTA (TNFB)NOL3 (CARD6)TNFRSF25 (DR3)XIAP
Neuron Development
BDNFKIT (CD117)LEFTY2LTA (TNFB)NOTCH4SEMA3B
Metabolism (Regulation & Mechanism)
BDNFCCND1CDO1DRD2EIF2AK3GALCGRIN1HTR1AKIT (CD117)LDHAGSR (GSR)LOC710540 (CAMK2A)NOTCH4PRIM2TPH1TXNIPTYRP1
Signal Transduction
BIRC2 (c-IAP1)CCND1DRD2EIF2AK3GSNHTR1AKIT (CD117)TACR1
Ion Transporters
DRD2GRIN1
Other Genes Down-Regulated in Neurotoxicity
COL12A1EGLN3HTR3ANUP50
Other Neurotoxicity Genes
TPI1