Target List
Autophagy Machinery Components
Autophagic Vacuole Formation​
Ambra1, Atg12, Atg16l1, Atg4b, Atg4c, Atg5, Atg9a, Becn1, Ctsd, Gabarap, Gabarapl2, Irgm, Map1lc3a, Map1lc3b, Psen1, Rb1cc1, Atg101, Rgs19, Tm9sf1, Ulk1, Wipi1
Vacuole Targeting​
Atg4b, Atg4c, Gabarap
Protein Transport​
Atg16l1, Atg16l2, Atg3, Atg4b, Atg4c, Atg7, Atg9a, Gabarap, Gabarapl2, Rab24
Ubiquitination​
Atg3, Atg7, Park2 (QuantiNova Symbol: AABR07001519.1), Park7, Pink1
Proteases​
Atg4b, Atg4c
Regulation of Autophagy
Co-Regulators of Autophagy & Apoptosis​
Akt1, App, Atg12, Atg5, Bad, Bak1, Bax, Bcl2, Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Becn1, Bid, Bnip3, Casp3, Casp8 (Flice), Npc1, Cdkn1b (P27KIP1), Cdkn2a (INK4A, p16, p19ARF), Cln3, Ctsb, Cxcr4, Dapk1, Eif2ak3, Fadd, Fas, Hdac1, Htt, Ifng, Igf1, Ins2, Mapk8 (Jnk1), Mtor, Nfkb1, Park2 (QuantiNova Symbol: AABR07001519.1), Pik3cg, Prkaa1 (Ampk), Pten, Snca, Sqstm1, Tgfb1, Tgm2, Tnf, Tnfsf10 (Trail), Tp53 (p53)
Co-Regulators of Autophagy & the Cell Cycle​
Bax, Cdkn1b (P27KIP1), Cdkn2a (INK4A, p16, p19ARF), Ifng, Mapt, Pim2, Pten, Rb1, Tgfb1, Tp53 (p53)
Autophagy Induction by Intracellular Pathogens​
Eif2ak3, Ifng, Lamp1
Autophagy in Response to Other Intracellular Signals​
Arsa, Ctss, Dram2, Eif4g1, Esr1 (Erα), Gaa, Hdac6, Hgs, Mapk14 (p38alpha), Pik3c3 (Vps34), Pik3r4, Rps6kb1
Chaperone-Mediated Autophagy​
Hsp90aa1