Target List
Caspases & Regulators
Caspases
Casp1 (Ice), Casp14, Casp2, Casp3, Casp4, Casp6, Casp7, Casp8 (Flice), Casp9, Cflar (Casper), Malt1, Pycard (Tms1, Asc)
Caspase Activation
Apaf1, Bax, Bbc3, Bcl2l10, Bcl2l13, Casp1 (Ice), Casp8ap2, Casp9, Cdkn2a (INK4A, p16, p19ARF), Col4a3, Cycs, Diablo (Smac), Eif2ak3, F2 (Thrombin), F2r (Par1), Foxl2, Hip1, Hspe1, Ifnb1, Ift57, Lck, Mtch1, Myc, Nlrc4 (Ipaf), Nlrp12, Nlrp1a (Nalp1), Nlrp3, Pmaip1 (NoxA), Pycard (Tms1, Asc), Rhoa, Stat1, Tnfsf15, Tp53 (p53), Vcp
Caspase Inhibition
Birc5, Cd27 (Tnfrsf7), Cdh1 (E-cadherin), Dhcr24, Lamtor5, Nr4a1 (Nur77), Sfn (14-3-3σ), Tnfaip8, Tnfsf14, Xiap
Anti-Apoptotic
Positive Regulation of Anti-Apoptosis
Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bre, Cd28, Erc1, Il6, Mapk8ip2, Opa1, Prkaa1 (Ampk), Rasa1
Negative Regulation of Anti-Apoptosis
Pik3r2, Rtn4, Tnfaip8
Other Anti-Apoptotic Genes
Aatf, Akt1, Alox12, Anxa1, Anxa4, Api5, Atf5, Aven, Bag1, Bag3, Bag4, Bcl2, Bcl2a1 (Bfl-1, A1), Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bcl2l10, Bcl2l2, Bdnf, Becn1, Bfar, Birc2 (c-IAP2), Birc3 (c-IAP1), Birc5, Birc6, Birc7, Bnip1, Bnip2, Bnip3, Braf, Casp2, Ccl12, Ccl2 (Mcp-1), Cd27 (Tnfrsf7), Cd40lg, Cebpb, Cfdp1, Cfl1, Cflar (Casper), Cryaa, Cryab, Dad1, Ddah2, Dhcr24, Eef1a2, Faim, Faim2, Fas, Gdnf, Glo1, Gstp1, Hdac1, Hdac3, Hgf, Hipk3, Hsp90b1, Hspa1b, Hspa9, Hspb1 (Hsp27), Htatip2, Htt, Ier3, Igf1, Igf1r, Il10, Il1a, Il2, Il7, Lamtor5, Malt1, Mcl1, Mpo, Mtl5, Mybl2, Naip6 (QuantiNova Symbol: AC135826.1), Nfkb1, Ngf, Nol3, Notch2, Nr3c1 (QuantiNova Symbol: AABR07031756.1), Nrg2, Ntf3, Pak7, Pea15, Pik3ca (p110-alpha), Pogk, Polb, Prdx2, Prkcz, Prlr, Prnp, Prok2, Psen1, Rela, Rnf7, Sema4d, Serpinb2 (Pai-2), Serpinb9, Sfrp1, Sh3glb1, Snca, Socs2, Socs3, Sod1, Sod2, Son, Sphk1, Spp1, Stambp, Tax1bp1, Tbx3, Tgfb1, Tmx1, Tnf, Tnfaip8, Tnfsf18, Tsc22d3, Vegfa, Vhl, Xiap, Ywhaz, Zc3hc1
Induction of Apoptosis
Induction of Apoptosis by Death Domain Receptors
Bid, Daxx, Fadd, Il18, Tnf, Tnfrsf10b (QuantiNova Symbol: AABR07018323.1)
Induction of Apoptosis by DNA Damage
Abl1, Aifm1, Atm, Brca1, Cdkn2a (INK4A, p16, p19ARF), Chek2, Cidea, Cideb, Dffb, Dyrk2, Mbd4, Pml, Sfn (14-3-3σ), Tp53 (p53), Tp73
Induction of Apoptosis by Oxidative Stress
Gpx1, Jak2, Prodh1, Rnf7
Induction of Apoptosis by Extracellular Signals
Adora1, Btk, Casp8ap2, Cd28, Cd38, Cd5, Cflar (Casper), Dap, Dap3, Dapk1, Dpf2, Fastk, Mapk9 (Jnk2), Ngf, Pdcd6, Prkca, Ripk3, Spn, Timp3, Tnfrsf25 (Dr3)
Induction of Apoptosis by Intracellular Signals
Cdkn1a (Cip1, Waf1), Cul1, Cul2, Cul3, Cul4a, Cul5, Hipk2, Htra2, Myc, Sart1
Other Pro-Apoptotic Genes
Acvr1b, Aifm2, Alox15b, Apoe, App, Bad, Bak1, Bax, Bbc3, Bcl10, Bcl2l11, Bcl2l13, Bclaf1, Bik, Bnip1, Bnip3, Bnip3l, Bok, Casp3, Casp4, Casp6, Cd2, Cd27 (Tnfrsf7), Cd70 (Tnfsf7), Cdkn1b (P27KIP1), Cebpb, Col4a3, Dapk2, Dapk3, Dcc, Ddx20, Dedd, Diablo (Smac), Ei24, Ercc3 (Xpb), Ern1, Ern2, Fas, Faslg, Fem1b, Foxl2, Foxo3, Hmgb1 (QuantiNova Symbol: AABR07035218.1), Hrk, Htatip2, Htt, Ifna2, Ifnb1, Ikbip (Ikip), Ikbkg, Inha, Inhba, Lalba, Lck, Lta (Tnfb), Mal, Map3k10, Mapk1 (Erk2), Mx2, Ndufs3, Ngfr, Nlrp1a (Nalp1), Nlrp3, Nme3, Notch2, Nr4a1 (Nur77), Nudt2, Nupr1, Pdcd5, Plagl1, Plagl2, Plekhf1, Plg, Pmaip1 (NoxA), Ppp1r13b, Ppp2ca, Ppp2r1a, Ppp2r1b, Prkce, Prkra, Prune2, Pten, Pth, Pycard (Tms1, Asc), Rps3a, Runx3, S100b, Sap30bp, Serinc3, Sipa1, Siva1, Smndc1, Sst, Sstr3, Stk17b, Tbx5, Tia1, Tial1, Tlr2, Tnfrsf9, Tnfsf10 (Trail), Tnfsf14, Tp53bp2, Tp63, Tradd, Traf3, Traip, Unc13b, Utp11l
TNF Domain Proteins
Faslg, Lta (Tnfb), Ltb, Tnf, Tnfsf10 (Trail), Tnfsf14, Tnfsf15
TNFR Domain Proteins
Cd27 (Tnfrsf7), Cd40, Fas, Ltbr, Ngfr, Tnfrsf10b (QuantiNova Symbol: AABR07018323.1), Tnfrsf11b (Opg), Tnfrsf1a (Tnfr1), Tnfrsf1b, Tnfrsf21, Tnfrsf25 (Dr3), Tnfrsf8, Tnfrsf9
BCL2 & BAG Domain Proteins
Bag1, Bag3, Bag4, Bax, Bcl2, Bcl2a1 (Bfl-1, A1), Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bcl2l10, Bcl2l13, Bcl2l2, Mcl1
BIR Domain Proteins
Birc2 (c-IAP2), Birc3 (c-IAP1), Birc5, Birc6, Birc7, Naip6 (QuantiNova Symbol: AC135826.1)
CARD Domain Proteins
Apaf1, Bcl10, Birc2 (c-IAP2), Birc3 (c-IAP1), Card10, Card11 (QuantiNova Symbol: AABR07035470.1), Card6, Card9, Casp1 (Ice), Casp2, Casp4, Casp9, Nlrp1a (Nalp1), Nod2, Nol3, Pycard (Tms1, Asc), Ripk2
Death Domain Receptors
Dapk1, Fadd, Malt1, Nfkb1, Nfkb2, Ngfr, Pidd1, Ripk1, Tradd
TRAF Domain Proteins
Traf2, Traf3, Traf7
Other Apoptosis Regulators
Agt, Agtr1a, Ahr, Akt1s1 (Pras40), Apc, Bcl6, Cebpg, Col18a1, Csf2 (Gm-csf), Csf2 (Gm-csf), Csf2 (Gm-csf), Ctnnb1, Dbp, Ddit3 (Gadd153, Chop), Dffa, E2f1, Endog, Ep300 (QuantiNova Symbol: AABR07058539.1), Epo, Esr2 (Erβ), Fgf2 (bFGF), Gli2, Grm4, Gsk3b, Hif1a, Hras, Id1, Ifng, Il2ra (Cd25), Il4, Ins2, Kitlg (Scf), Kitlg (Scf), Krt18, Krt8, Lgals1, Madd, Mapk8 (Jnk1), Mmp9, Notch1, Ntrk1, Pou4f1, Prkdc, Prop1, Ptprc (Cd45), Raf1, Shh, Stat5a, Stat5b, Tbk1, Tdgf1, Traf6