Target List
Induction of Apoptosis
Death Domain Receptors​
TNF, TNFRSF11B, TNFRSF1A, TNFRSF1B
DNA Damage & Repair​
ABL1, CIDEA, CIDEB, TP53 (p53)
Extracellular Apoptotic Signals​
LOC100516103
Other Pro-Apoptotic Genes​
AIFM3, BAD, BAK1, BAX, BID, BNIP3L, CASP1, CASP10, CASP14, CASP2, CASP3, LOC100522887, CASP6, CASP8 (FLICE), CD40, CD70 (TNFRSF7), CYCS, CUL2, DFFA, DDX20, DPF2, DIABLO, ERN2, FAS (TNFRSF6), FASLG (TNFSF6), FEM1B, GADD45A, HRK, LTA (TNFB), LTBR, LALBA, NOD1, LOC100522011, PPP2R1A, PPP2R1B, SART1, LOC100517325, TNFSF10 (TRAIL), TP53BP2, TRAF2
Anti-Apoptotic
AKT1, BAG3, BAX, BCL2, BCL2A1, BCL2L1 (BCL-X, BCLXL), BCL2L10, LOC100154044, BRAF, LOC100622859, BIRC3, BIRC5, BNIP2, BNIP3L, CBX4, BNIP3, CD40LG (TNFSF5), CFDP1, LOC100516103, ERC1, FAS (TNFRSF6), HRK, IGF1R, IL10, MCL1, MTL5, NFKB1, LOC100523672, RIPK2, PAK7, STAMBP, TNF, XIAP
Death Domain Receptors
LOC100516103, TNFRSF21, TNFRSF11B, TNFRSF1A, TNFRSF1B
Caspases & Regulators
Caspases​
CASP1, CASP10, CASP14, CASP2, CASP3, LOC100522887, CASP6, CASP8 (FLICE), LOC100156777 (CASP7), CASP9, LOC641352 (Caspase 15), LOC100522011
Caspase Activation​
AIFM1, AIFM3, APAF1, BAX, BCL2L10, CASP1, NOD1, LOC100522011, TP53 (p53)
Caspase Inhibition​
XIAP
Other Regulators of Apoptosis
PROP1, RFWD2