Target List
HIF1 & Co-Transcription Factors
ARNT, COPS5, HIF1A, HIF3A, HNF4A, NCOA1, PER1
Other HIF1 Interactors
APEX1, EGLN1, EGLN2, NFKB1, P4HA1, TP53 (p53)
Hypoxia Responsive Genes
Angiogenesis​
ADORA2B, ANGPTL4, ANXA2, BTG1, EGR1, EDN1, EPO, F3, GPI, HMOX1, JMJD6, LOX, MMP9, PGF, PLAU (uPA), SERPINE1 (PAI-1), VEGFA
Coagulation​
ALDOC, ANXA2, F10, F3, PLAU (uPA), SERPINE1 (PAI-1), SLC16A3
DNA Damage & Repair​
ATR, MIF, NDRG1, RUVBL2
Metabolism​
ALDOC, DDIT4 (REDD1), ENO1, ERO1A, GBE1, GPI, GYS1, HK2, LDHA, PDK1, PFKFB3, PFKFB4, PFKL, PFKP, PGAM1, PGK1, PKM, SLC2A1, SLC2A3, TPI1
Regulation of Apoptosis​
ADM, BNIP3, BNIP3L, BTG1, DDIT4 (REDD1), IER3, MIF, NOS3 (eNOS), PIM1
Regulation of Cell Proliferation​
ADM, BTG1, BLM, CCNG2, EGR1, IGFBP3, LOC100154269 (MXI1), MET, MIF, NAMPT, NOS3 (eNOS), ODC1, PGF, PIM1, TXNIP
Transcription Factors​
BHLHE40 (DEC1), FOS, RBPJ, USF2
Transporters, Channels & Receptors​
SLC2A1, SLC2A2, SLC2A3, SLC16A3, TFRC, VDAC1
Other Hypoxia Responsive Genes​
ANKRD37, CA9, CTSA, DNAJC5, EIF4EBP1 (4E-BP1), FAM162A, LGALS3, MAP3K1 (MEKK1)